Nano-ink gel could replace repeated skull surgeries for kids with rare genetic disorders

NCT ID NCT07535372

Not yet recruiting Disease control Sponsor: Fondazione Policlinico Universitario Agostino Gemelli IRCCS Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This early-stage study aims to develop a personalized treatment for children with syndromic craniosynostosis, a group of rare genetic disorders where skull bones fuse too early. The approach uses a nano-engineered gel to deliver custom genetic medicine directly to the affected area, potentially reducing the need for repeated surgeries. The study involves 12 children aged 0-5 years and will first test the treatment in lab-grown cells and mouse models.

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Conditions

The condition(s) this trial relates to.

Apert syndrome craniofrontonasal syndrome craniosynostosis Crouzon syndrome Muenke syndrome Pfeiffer syndrome Saethre-Chotzen syndrome syndromic craniosynostosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

APERT SYNDROME CRANIOSYNOSTOSES CROUZON SYNDROME MUENKE SYNDROME PFEIFFER SYNDROME SAETHRE CHOTZEN SYNDROME

Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

Institut Imagine

Paris, France

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