Spleen stiffness scan could spare liver patients painful biopsies
NCT ID NCT07440511
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study is testing whether measuring spleen stiffness with a special ultrasound probe can detect advanced liver scarring in people with metabolic fatty liver disease (MASLD). Researchers will follow 500 adults for up to several years to see if the test predicts serious liver problems like cirrhosis or liver cancer. The goal is to replace invasive liver biopsies with a quick, painless scan.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- spleen stiffness measurement (non-invasive ultrasound-based test)
- What this could lead to
- If successful, this could provide a simple, needle-free way to detect advanced liver scarring early and predict complications in people with fatty liver disease.
- What could go wrong
- This is an observational study, not a treatment trial. The test may not prove accurate enough to replace current methods, and results may not apply to all patients.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Fondazione Policlinico Universitario A. Gemelli IRCCS
RECRUITINGRome, 00168, Italy
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