MRI-Guided radiation boosts hopes for rectal cancer patients
NCT ID NCT04815694
First seen Jul 10, 2026 · Last updated Jul 10, 2026
Summary
This trial investigates whether adjusting radiation doses based on early tumor shrinkage seen on daily MRI scans can improve outcomes for people with locally advanced rectal cancer. Participants receive standard chemoradiation, but those whose tumors shrink slowly get a higher radiation dose to the remaining tumor. The study also collects blood and stool samples to build better prediction models. The main goal is to see if this personalized approach leads to more complete tumor disappearances.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Radiation dose escalation (up to 60.1 Gy) guided by MRI and early tumor regression index
- What this could lead to
- If successful, this approach could increase the number of patients who achieve a complete response, potentially avoiding surgery and improving survival.
- What could go wrong
- This is a single-center, non-randomized study, so results may not apply broadly. Dose escalation also carries a risk of increased side effects to nearby organs.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for LOCALLY ADVANCED RECTAL CANCER are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Show contact details
Enter your email to view the contact information for this study.
By submitting, you agree to our Terms of use
Study contacts
-
Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
-
Fondazione Policlinico Universitario A.Gemelli IRCCS
RECRUITINGRoma, Roma, 00168, Italy
Contact Phone: •••-•••-•••• Email: •••••@•••••
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Can a short burst of radiation plus triple chemotherapy wipe out rectal cancer before surgery?
- Timing of chemo may boost rectal cancer remission
- Immune-boosting combo aims to wipe out rectal cancer before surgery
- New combo without chemotherapy aims to shrink rectal tumors before surgery
- Could chemo replace surgery for rectal cancer? new study explores
- Oxygen-Boosting injection may help rectal cancer patients avoid surgery