Hunting for hidden antibodies in brain inflammation

NCT ID NCT07477015

Recruiting now Knowledge-focused Sponsor: Fondazione Policlinico Universitario Agostino Gemelli IRCCS Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study aims to better understand autoimmune encephalitis, a condition where the immune system attacks the brain. Researchers will analyze blood and spinal fluid from 20 patients to find new antibodies that may explain the disease in people who currently test negative. The goal is to improve diagnosis and uncover the underlying causes of this rare disorder.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this could help identify new antibodies that explain the disease in currently undiagnosed patients, potentially leading to better diagnostic tests.
What could go wrong: This is a small, early-stage observational study with only 20 participants, so findings may not apply broadly. Discovering new antibodies is uncertain and may not directly lead to treatments.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

anti-NMDA receptor encephalitis autoimmune disorder of the nervous system autoimmune encephalitis limbic encephalitis with LGI1 antibodies Susac syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

AUTOIMMUNE ENCEPHALITIS

Contacts and locations

Locations

Fondazione Policlinico Universitario A. Gemelli IRCCS
RECRUITING

Rome, RM, 00168, Italy

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