Can diabetes and heart drugs help failing right hearts? new trial launches

NCT ID NCT06570473

Recruiting now Disease control Sponsor: University of Alberta Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This phase 2 trial is testing whether two existing drugs, empagliflozin (used for diabetes) and ranolazine (used for chest pain), can improve right heart function in 30 people with pulmonary hypertension and right heart failure. Participants will receive one of the drugs plus standard care, or standard care alone. The main goal is to see if a larger study is feasible, not yet to prove the drugs work.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Empagliflozin (Jardiance) and Ranolazine (Corzyna)
What this could lead to: If successful, this could point toward new treatment options for right heart failure in people with pulmonary hypertension.
What could go wrong: This is a small, early feasibility trial with only 30 people, so results may not apply to everyone. The main goal is to see if a larger trial is possible, not to prove the drugs work.

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Conditions

The condition(s) this trial relates to.

heart failure pulmonary hypertension Ventricular Dysfunction, Right

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PULMONARY HYPERTENSION RIGHT HEART FAILURE RIGHT VENTRICULAR DYSFUNCTION

Contacts and locations

Locations

London Health Sciences Centre - University Hospital
NOT_YET_RECRUITING

London, Ontario, N6A 5A5, Canada
The Ottawa Hospital
NOT_YET_RECRUITING

Ottawa, Ontario, K1Y 4E9, Canada
The University of British Columbia
NOT_YET_RECRUITING

Vancouver, British Columbia, V5Z 1M9, Canada
University of Alberta
RECRUITING

Edmonton, Alberta, T6G 2G3, Canada
University of Calgary
NOT_YET_RECRUITING

Calgary, Alberta, T1Y 6J4, Canada

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