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Can a diabetes drug help the lungs? pioglitazone put to the test for pulmonary hypertension

NCT ID NCT06336798

Recruiting now Disease control Sponsor: Emory University Source: ClinicalTrials.gov ↗

First seen Jul 22, 2026 · Last updated Jul 23, 2026 · Updated 1 time

Summary

This phase 2 trial tests whether pioglitazone, a drug used for diabetes, can improve how cells use oxygen in people with pulmonary hypertension caused by chronic lung disease. Participants take pioglitazone or a placebo daily for 28 days, then switch after a 2-week break. The study measures changes in mitochondrial function and monitors safety.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
pioglitazone (Actos), a diabetes drug, taken as a 30 mg pill daily
What this could lead to
If it works, this could point toward a new treatment for pulmonary hypertension caused by chronic lung disease.
What could go wrong
This is a small, early-phase trial with only 20 participants, so results may not apply broadly. Pioglitazone can cause side effects like hypoglycemia and leg swelling.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

pulmonary hypertension pulmonary hypertension owing to lung disease and/or hypoxia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PULMONARY HYPERTENSION PULMONARY HYPERTENSION DUE TO LUNG DISEASES

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Emory Healthcare System

    RECRUITING

    Atlanta, Georgia, 30322, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

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