Pulmonary hypertension

This study tests the safety of a new medicine called sotatercept for adults in India with pulmonary arterial hypertension (PAH), a condition where blood vessels in the lungs become narrow, making breathing hard. About 30 people will receive sotatercept along with their usual trea…

This trial will compare three drugs—dopamine, norepinephrine, and epinephrine—to see which works best for people experiencing a pulmonary hypertensive crisis, a life-threatening spike in blood pressure in the lungs. The study will enroll 75 adults with pulmonary arterial hyperten…

This study tests whether a 12-week tele-pulmonary rehabilitation program, done at home via an app with a physiotherapist, helps people with chronic lung diseases start and stick with rehab better than going to a center. 90 patients will be randomly assigned to either remote rehab…

This phase 2 trial tests a dietary supplement called 2-HOBA in 12 adults with pulmonary arterial hypertension (PAH), a condition where high blood pressure in the lungs strains the heart. Participants take the supplement three times daily for 12 weeks. The study checks if 2-HOBA i…

This study tests the safety and tolerability of sotatercept in Japanese children aged 1 to 18 with pulmonary arterial hypertension (PAH), a condition where blood vessels in the lungs narrow, making the heart work harder. Participants receive sotatercept injections every three wee…

This study tests whether a 12-week program of moderate aerobic exercise and inspiratory muscle training can improve breathing, exercise capacity, and quality of life in people with pulmonary hypertension caused by lung disease. Participants will walk on a treadmill and use a brea…

This study looks at people with a rare lung condition called CTEPH who have done well after a procedure (balloon angioplasty) and are taking a drug called riociguat. The goal is to see if stopping the drug is as safe as continuing it. About 150 participants will be randomly assig…

This study is checking the long-term safety of a daily pill called IKT-001 for people with pulmonary arterial hypertension (PAH), a serious lung condition. About 484 adults who have already completed an earlier IKT-001 study will take the drug for an extended period. Researchers …

This study compares two drugs, vasopressin and norepinephrine, given during and after surgery to remove chronic blood clots from the lungs. The goal is to see which drug better controls blood pressure in the lungs without harming the rest of the body. About 90 adults scheduled fo…

This Phase 3 study tests VI-0106, an extended-release form of tacrolimus, in 300 people with pulmonary arterial hypertension (PAH) who still have trouble with daily activities despite taking standard PAH medications. Participants will receive either the drug or a placebo for 24 w…

This study will test if a smart pill bottle cap, called FORTISKAP™, helps people with serious lung diseases like pulmonary fibrosis, sarcoidosis, and pulmonary hypertension take their oral medications more consistently. About 100 participants will either use the smart cap or rece…

This phase 3 study tests the long-term safety of an inhaled drug called treprostinil palmitil for people with pulmonary hypertension caused by interstitial lung disease. About 344 adults who completed an earlier trial will take the drug for up to 2 years. Researchers will track s…

This phase 2 trial tests whether adding tiprelestat (elafin) to standard care improves blood flow in the lungs for people with pulmonary arterial hypertension (PAH). About 90 adults with moderate to severe PAH will receive either a daily injection of tiprelestat or a placebo for …

This small pilot study will test a program where nurses and general practitioners help breast cancer survivors who also have heart disease make healthy lifestyle changes. The program includes exercise, diet changes, quitting smoking, and stress-reducing activities like yoga. The …

This study tests whether the drug vericiguat can prevent serious heart and organ problems in people undergoing heart surgery. About 600 high-risk patients will receive either vericiguat plus standard care or standard care alone. The goal is to see if vericiguat reduces early comp…

This study tests a new method for closing the breastbone after coronary artery bypass graft (CABG) surgery using special knotless barbed sutures and a skin adhesive. Researchers will compare 401 adults who receive this new closure to past patients who had standard closure. The go…

This study tests whether the drug telaglenastat, taken twice daily for 12 weeks, can safely lower blood pressure in the lungs and improve heart and lung function in adults with pulmonary hypertension. About 28 participants will receive the drug on top of their usual care. The mai…

This study tests a drug called sotatercept in 40 adults with congenital heart disease and Eisenmenger syndrome, a serious condition where blood flow in the lungs is blocked. The drug is given as a shot every three weeks for 24 weeks. The goal is to see if it safely lowers pressur…

This study will test whether the drug sotatercept can reverse damage to the lung's blood vessels in people with pulmonary arterial hypertension (PAH). Researchers will use special imaging techniques to look inside the arteries and see if they become healthier over 9 months. The s…

This phase 2 trial tests an injected drug called TX000045 in 25 people who have high blood pressure in the lungs due to scarring lung disease. The main goal is to see if the drug lowers lung blood pressure and is safe over 16 weeks. Researchers will also check for side effects an…

This study tests a device that uses radiofrequency energy to treat high blood pressure in the lungs (pulmonary hypertension) in people with heart failure. The goal is to see if it can reduce serious heart events like hospitalizations or death. About 750 adults with stable heart f…

This study looks at how well the oral medication selexipag works over the long term for people with a specific type of lung hypertension caused by schistosomiasis (a parasitic infection). Researchers will compare patients who received selexipag as part of routine care to similar …

This Phase 2 trial tests an oral drug called NS-863 in 177 adults with pulmonary hypertension linked to interstitial lung disease (PH-ILD). Participants will receive either a low dose, high dose, or placebo for 24 weeks. The main goal is to see if the drug improves blood vessel r…

This Phase 2 trial tests an oral drug called NS-863 in 135 adults with pulmonary arterial hypertension (PAH), a condition where high blood pressure in the lungs makes it hard to breathe. Participants will receive either a low dose, high dose, or placebo for 24 weeks. The main goa…

This study tests whether a special clinic where heart, kidney, diabetes, and liver doctors work together can help people with type 2 diabetes and heart disease get better control of their blood pressure and cholesterol. About 150 adults will be randomly assigned to either usual c…

This study tests a community-based exercise program for people aged 50 and older who have at least two chronic conditions, such as heart disease, diabetes, arthritis, or obesity. The program is designed to improve muscle strength, heart and lung fitness, and overall well-being. R…

This early study tests a single dose of stem cells (PNEUMOSTEM®) given into the windpipe of very premature babies with high blood pressure in their lungs. The goal is to see if it is safe and might improve breathing, reduce time on a ventilator, and lower the need for oxygen. Onl…

This study tests whether taking vitamin B supplements before and after heart surgery can lower the chance of serious problems like heart attack, stroke, or irregular heartbeat. About 1,000 adults having heart surgery will take either vitamin B or a placebo daily for 6 months afte…

This study looks at whether a medical-grade smartwatch (CardioWatch 287-2) can improve a 13-week virtual cardiac rehab program for people with heart disease. About 216 participants will either use the watch or not, and researchers will compare their progress in areas like exercis…

This phase 2 trial tests whether a triple combination of three drugs—sotatercept, an endothelin receptor antagonist, and a phosphodiesterase-5 inhibitor—can improve blood flow in the lungs of people newly diagnosed with pulmonary arterial hypertension (PAH). The study will enroll…

This study looks at whether the inhaled drug iloprost can safely lower blood pressure in the lungs and improve exercise ability in adults with severe COPD. Fifteen participants will take iloprost 6 to 9 times daily for 12 weeks, with tests before and after treatment. There is no …

This study looks at whether inhaled nitric oxide can help newborns with a hole in their diaphragm (congenital diaphragmatic hernia) who also have high blood pressure in their lungs. About 40 babies will receive the gas, and doctors will check if their oxygen levels improve within…

This study tests whether adding an injectable medication called treprostinil to standard oral therapy can improve heart function in people with intermediate-risk pulmonary arterial hypertension (PAH). About 32 adults will receive the drug for 3 months, with heart scans and walkin…

This study tests Mobili®, a portable digital dispenser that automatically gives the right pills at the right time. Researchers will enroll 96 adults with diabetes or heart disease who take at least two daily medications. Participants use the device for a period, and the study mea…

This study tests a new radioactive tracer called 18F-FAPI-74 that may help detect scar tissue (fibrosis) in the heart and lungs earlier than current methods. Researchers will compare this new PET/CT scan to standard imaging in 210 adults with conditions like lung disease or heart…

This study looks at whether comparing a patient's previous pulmonary artery pressure (PAP) reading with one taken during an ER visit can help doctors quickly identify a pulmonary embolism (a blood clot in the lung). Researchers will review records of 80 adults who come to the ER …

This study tests whether an artificial intelligence system can analyze standard heart tracings (ECGs) to detect pulmonary hypertension—a serious but often unnoticed condition—before surgery. About 1,380 adults scheduled for non-cardiac surgery will be randomly assigned to get the…

This pilot study explores whether non-drug strategies like virtual reality or relaxing soundscapes can reduce anxiety and pain in adults undergoing scheduled coronary angiography or angioplasty. Participants will be assigned to listen to calming sounds, experience a virtual reali…

This study tests whether low-intensity focused ultrasound (LIFU) applied to a nerve cluster in the neck can improve sleep quality and heart rate control in people recovering from heart surgery. 200 participants will receive either real or sham ultrasound daily for 3-7 days after …

This study tests whether a 16-week home exercise program can improve daily function in 30 adults with pulmonary hypertension linked to interstitial lung disease. Participants will receive daily texts or emails with aerobic and strength exercises. Researchers will measure changes …

This study looks at whether a supplement called Neurofast® can help people who have both anxiety and heart problems. 80 adults aged 18-70 will take the supplement or no extra treatment for 12 weeks. Researchers will measure changes in anxiety, heart rate, and blood pressure.

This study follows 32 adults with pulmonary arterial hypertension (PAH) whose doctors decide to switch them from inhaled iloprost (taken several times a day) to oral selexipag (a pill). Researchers will use questionnaires to see if the switch improves quality of life, treatment s…

This study tests whether adding a short, guided mindfulness meditation session to standard cardiac rehabilitation can help heart patients feel better and control their blood pressure. Eighty adults with heart disease will be split into two groups: one gets standard rehab plus med…

This study will compare cannabis, opioids, and two non-drug therapies (MIRE and TENS) in 1,000 people with chronic pain or circulatory disorders. The goal is to find safer, less addictive pain relief options. Researchers will measure changes in pain and nerve function using objec…

This study uses advanced 4D MRI scans to measure blood flow and heart function in adults with heart disease or cancer. Researchers aim to see if these detailed images can help predict how these diseases will progress. The study involves 1,000 participants who are already schedule…

This study gathers data from 392 adults with heart failure who need a right heart catheterization. Researchers will use the data to train a machine learning model for a non-invasive device that estimates heart pressure. The goal is to help doctors monitor and treat heart failure …

This study looks at why people with end-stage kidney disease on dialysis often develop high blood pressure in the lungs (pulmonary hypertension). Fluid buildup can make this condition seem worse than it is. Researchers will first correct fluid levels, then use heart ultrasound an…

This study will interview 15 people from ethnic minority backgrounds in the UK who have heart disease. The goal is to understand their views on the diet and lifestyle advice they get from doctors, and whether it fits their cultural and religious customs. Researchers hope to learn…

This study checks whether an Apple Watch Series 9 can accurately measure key health indicators—like oxygen levels and exercise capacity—in adults with heart conditions such as congenital heart disease, heart failure, or coronary artery disease. Participants wear the smartwatch du…

This study is creating a large collection of blood samples and medical information from 1000 adults with or suspected of having pulmonary hypertension (PH). Researchers hope this resource will help them find new ways to diagnose and treat PH. Participants will provide a blood sam…

This study will look at 60 adults with a type of high blood pressure in the lungs (pre-capillary pulmonary hypertension) to see if measurements from a CT scan match those from a standard invasive heart catheter test. If the CT scan proves reliable, it could offer a safer, less in…

This study tests whether it is possible to run a larger trial comparing two ways of using a breathing machine (ventilator) in critically ill heart patients who need help breathing. The two modes are volume-controlled (delivers a set amount of air each breath) and pressure-control…

This pilot study will use special PET/CT scans to see how the experimental drug sotatercept affects blood vessel remodeling in the lungs and heart of people with pulmonary arterial hypertension (PAH). About 15 adults with PAH will receive sotatercept and have imaging at the start…

This study looks at whether mindfulness-based stress reduction can help Black teenage girls who have been involved with the justice system and their parents or caregivers. About 90 participants will report on stress, PTSD symptoms, and other outcomes before and after the program.…

This observational study at a French hospital will ask 20 heart rehab patients and their care teams about what stops them from getting or offering psychological and social support. The goal is to understand these barriers so that hospitals can better help patients return to work …

This study aims to see if a quicker MRI scan can produce images of blood vessel walls that are just as good as the standard, longer scan. Researchers will enroll 15 adults who already need a vessel wall MRI as part of their care. The faster scan will be compared to the regular on…

This study looks at whether placing patients face-down (prone) soon after heart surgery can improve how well the right side of the heart works. The idea is that this position helps open up collapsed parts of the lungs, making it easier for the heart to pump blood. About 80 adults…

This study aims to find out how often people with FLNA gene mutations develop emphysema, a type of lung disease. Researchers will use chest CT scans, blood tests, and lung function tests in 70 participants. The goal is to confirm if FLNA changes are a cause of unexplained emphyse…

This study will create and test a new questionnaire to measure quality of life in Chinese patients with pulmonary arterial hypertension (PAH), a serious lung condition. Researchers will work with 300 adults to ensure the tool is accurate and useful for doctors and health policy. …

This pilot study will test whether a women-focused education program, called Cardiac College for Women, helps women with heart disease learn more about their condition and feel better. About 50 women in cardiac rehab across Canada will either get the program plus usual care or us…

This study will look at how consistently nearly 6,000 adults in Italy take three newer cholesterol-lowering drugs (inclisiran, evolocumab, and alirocumab) over the long term. Researchers will analyze prescription records to measure adherence and persistence in everyday medical pr…

This study follows 60 adults with pulmonary hypertension (high blood pressure in the lungs) for 2 years. Researchers will measure breathing problems during sleep and heart rate changes to see how they relate to the disease. No new treatment is given; participants continue their u…

This study will check children under 18 with chronic liver disease for hidden heart problems. Doctors will use simple tests like ECG and ultrasound to look for issues such as abnormal heart rhythms or weakened heart muscle. The goal is to better understand how liver disease affec…

This study looks at how changes in the cells lining blood vessels relate to lung resistance in people with pulmonary artery hypertension (PAH). Researchers will measure certain blood markers and lung pressure in 6 adults with PAH. The goal is to better understand the disease, not…

This study will test new MRI methods to find early signs of heart disease in 1000 adults. Researchers want to see if these scans can detect tiny changes in heart muscle before standard tests do. Participants will have MRI scans and blood work, but no treatment is given. The goal …

This study will follow 300 adults who have both a portosystemic shunt (an abnormal blood vessel connection between the liver and the rest of the body) and pulmonary hypertension (high blood pressure in the lungs). Researchers want to learn more about how common this combination i…

This study looks at whether different types of exercise (like walking or strength moves) and timing (morning vs. evening) can safely lower blood pressure in people with glaucoma and high blood pressure. About 60 adults will try four exercise sessions, and their blood pressure and…

This study looks at whether environmental toxins, drugs, and workplace exposures play a role in causing pulmonary arterial hypertension (PAH), a rare and serious lung condition. Researchers will compare 150 newly diagnosed patients with PAH to those with another form of pulmonary…

This large registry study will follow over 2,700 postmenopausal women aged 45-75 who use newer forms of hormone replacement therapy (creams, gels, sprays). The goal is to see if these modern delivery methods lower the risk of heart attacks, strokes, and other cardiovascular event…

This study will follow 4,000 intensive care patients aged 80 and older to see how chronic and acute heart conditions impact their survival, daily function, and quality of life. Researchers will use simple tests to measure frailty and independence. The goal is to help doctors bett…

This observational study will review medical records of 15 adults with pulmonary arterial hypertension (PAH) who switched from one medication (a PDE5 inhibitor) to riociguat while already on triple therapy. The goal is to see if this switch improves exercise ability, symptoms, an…

This study will follow 500 Beijing residents aged 60 and older to see how urinary function (like bladder and kidney health) relates to the development of multiple chronic conditions such as diabetes, heart disease, and Alzheimer's. Participants will have regular health checks, bl…

This study aims to find genetic variants that may explain why some people with a rare liver bypass condition (congenital portosystemic shunt) develop a serious lung complication called portopulmonary hypertension. Researchers will analyze blood samples from 120 patients and their…

This study will measure a specific heart function index in 2,640 healthy adults and people with heart conditions using AI-enhanced 3D ultrasound. The goal is to establish normal ranges and see how this measurement changes in diseases like heart failure and high blood pressure in …

This study will ask 380 heart patients and healthcare workers at Assiut University Heart Hospital to fill out questionnaires about depression, anxiety, stress, and burnout. No treatments or changes are given—the goal is simply to find out how common these mental health problems a…

This study will follow 200 adults with pulmonary arterial hypertension who experience a sudden worsening of right heart failure. Researchers will collect medical data to see how many survive or need a lung transplant within 3 and 12 months. The goal is to identify better ways to …

This study uses a short questionnaire to learn where patients with pulmonary hypertension and their caregivers search for health information, what topics they look for, how satisfied they are, and which sources they trust most. Researchers will enroll 100 adults in Brazil. The go…

This study will test whether an artificial intelligence (AI) system can detect pulmonary hypertension and other heart diseases using a smart stethoscope. Researchers will collect heart sound and ECG recordings from 1,000 adults already scheduled for routine echocardiography. The …

This study will examine tissue and blood samples from 105 adults having lung surgery to understand why some people with chronic lung disease develop pulmonary hypertension (high blood pressure in the lungs). Researchers will compare three groups: those with lung disease and pulmo…

This study looks at how sleep disorders and problems with the body's automatic functions (like heart rate control) are linked in elderly people with heart disease. Researchers will study 210 patients aged 65 and older to find out how common sleep issues are and how they affect he…

This study will observe 55 adults with obstructive sleep apnea to see if the severity of their breathing pauses during sleep is linked to higher blood pressure in the lungs. Researchers will use echocardiography to measure lung artery pressure. The goal is to better understand th…

This study tests whether doctors can use ultrasound (instead of X-rays) to guide a thin tube called a Swan-Ganz catheter into the right heart artery in people with pulmonary hypertension. The goal is to see if this method is safe, fast, and accurate. About 35 adults will take par…

This study will follow 400 people receiving a stem cell transplant to see how often they develop heart problems like heart attacks, irregular heartbeat, or heart failure. Researchers will use heart scans, blood tests, and other tools to find early warning signs. The goal is to be…