Experimental drug telaglenastat aims to lower lung blood pressure
NCT ID NCT07223528
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether the drug telaglenastat, taken twice daily for 12 weeks, can safely lower blood pressure in the lungs and improve heart and lung function in adults with pulmonary hypertension. About 28 participants will receive the drug on top of their usual care. The main measure is a change in lung blood vessel resistance, assessed by a heart catheterization.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Telaglenastat (CB-839), a drug taken by mouth twice daily
- What this could lead to
- If it works, this could point toward a new treatment option for pulmonary hypertension that improves blood flow in the lungs and heart function.
- What could go wrong
- This is a small, early-phase trial with only 28 people and no placebo group, so results may not apply widely. The drug is not FDA-approved for this condition and may not work or could cause side effects.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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UPMC Presybeterian
Pittsburgh, Pennsylvania, 15213, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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