Can lung patients ditch their meds after procedure? new trial investigates
NCT ID NCT07644377
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 2 times
Summary
This study looks at people with a rare lung condition called CTEPH who have done well after a procedure (balloon angioplasty) and are taking a drug called riociguat. The goal is to see if stopping the drug is as safe as continuing it. About 150 participants will be randomly assigned to stop or continue riociguat and be followed for at least a year to check for worsening health.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
riociguat
What this could lead to
If successful, this could show that many CTEPH patients can safely stop taking riociguat after balloon angioplasty, reducing medication burden and side effects.
What could go wrong
This is a Phase 3 trial, but it's still early and small (150 participants). Stopping the drug might lead to worsening symptoms or complications in some patients.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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CHU Angers
Angers, 49000, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
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CHU Caen
Caen, 14034, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
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CHU Dijon Bourgogne
Dijon, 21000, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
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CHU Grenoble Alpes
Grenoble, 38700, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
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CHU Montpellier
Montpellier, 34295, France
Contact Email: •••••@•••••
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CHU Poitiers
Poitiers, 86000, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
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CHU Rouen
Rouen, 76031, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
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CHU Saint Etienne
Saint-Etienne, 42270, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Hôpital Bicêtre
Le Kremlin-Bicêtre, 94270, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Hôpital Brabois
Vandœuvre-lès-Nancy, 54500, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Hôpital Bretonneau
Tours, 37044, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Hôpital Européen Georges Pompidou
Paris, 75015, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Hôpital Gabriel Montpied
Clermont-Ferrand, 63000, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Hôpital Haut Levêque
Bordeaux, 33600, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Hôpital Larrey
Toulouse, 31059, France
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Hôpital Laënnec
Nantes, 44800, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Hôpital Nord
Marseille, 13915, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Hôpital Pontchaillou
Rennes, 35000, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Hôpital de la Cavale blanche
Brest, 29200, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Hôpital de la Timone
Marseille, 13005, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Institut Cœur-Poumon
Lille, 59037, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Nouvel Hôpital Civil
Strasbourg, 67091, France
Contact Phone: •••-•••-•••• Email: •••••@•••••