Can lung patients ditch their meds after procedure? new trial investigates
NCT ID NCT07644377
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 2 times
Summary
This study looks at people with a rare lung condition called CTEPH who have done well after a procedure (balloon angioplasty) and are taking a drug called riociguat. The goal is to see if stopping the drug is as safe as continuing it. About 150 participants will be randomly assigned to stop or continue riociguat and be followed for at least a year to check for worsening health.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- riociguat
- What this could lead to
- If successful, this could show that many CTEPH patients can safely stop taking riociguat after balloon angioplasty, reducing medication burden and side effects.
- What could go wrong
- This is a Phase 3 trial, but it's still early and small (150 participants). Stopping the drug might lead to worsening symptoms or complications in some patients.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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CHU Angers
Angers, 49000, France
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CHU Caen
Caen, 14034, France
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CHU Dijon Bourgogne
Dijon, 21000, France
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CHU Grenoble Alpes
Grenoble, 38700, France
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CHU Montpellier
Montpellier, 34295, France
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CHU Poitiers
Poitiers, 86000, France
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CHU Rouen
Rouen, 76031, France
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CHU Saint Etienne
Saint-Etienne, 42270, France
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Hôpital Bicêtre
Le Kremlin-Bicêtre, 94270, France
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Hôpital Brabois
Vandœuvre-lès-Nancy, 54500, France
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Hôpital Bretonneau
Tours, 37044, France
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Hôpital Européen Georges Pompidou
Paris, 75015, France
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Hôpital Gabriel Montpied
Clermont-Ferrand, 63000, France
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Hôpital Haut Levêque
Bordeaux, 33600, France
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Hôpital Larrey
Toulouse, 31059, France
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Hôpital Laënnec
Nantes, 44800, France
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Hôpital Nord
Marseille, 13915, France
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Hôpital Pontchaillou
Rennes, 35000, France
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Hôpital de la Cavale blanche
Brest, 29200, France
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Hôpital de la Timone
Marseille, 13005, France
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Institut Cœur-Poumon
Lille, 59037, France
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Nouvel Hôpital Civil
Strasbourg, 67091, France
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