Scientists probe hidden links between hormones and lung disease

NCT ID NCT01884051

Recruiting now Knowledge-focused Sponsor: Vanderbilt University Medical Center Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study looks at how hormones and metabolism are involved in pulmonary arterial hypertension (PAH), a serious lung condition. Researchers will measure sex hormone levels, insulin resistance, and test two potential treatments—metformin and ACE-2—in small groups. The goal is to understand the disease better and find new ways to treat it.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Metformin, ACE-2
What this could lead to: If successful, this could point toward new treatments for pulmonary arterial hypertension by targeting metabolic and hormonal pathways.
What could go wrong: This is an early-stage, observational study with multiple exploratory aims. The findings may not lead to a proven therapy, and the interventions tested (metformin, ACE-2) may not show benefit or could have side effects.

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Conditions

The condition(s) this trial relates to.

drug- or toxin-induced pulmonary arterial hypertension Familial Primary Pulmonary Hypertension heritable pulmonary arterial hypertension idiopathic pulmonary arterial hypertension pulmonary arterial hypertension pulmonary systemic sclerosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

APPETITE SUPPRESSANT ASSOCIATE PAH HERITABLE PULMONARY ARTERIAL HYPERTENSION IDIOPATHIC PULMONARY ARTERIAL HYPERTENSION SCLERODERMA ASSOCIATED PULMONARY ARTERIAL HYPERTENSION

Contacts and locations

Locations

Vanderbilt University Medical Center
RECRUITING

Nashville, Tennessee, 37232, United States

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