Could a common ED drug help heart valve patients breathe easier?

NCT ID NCT07462260

Recruiting now Disease control Sponsor: Sindh Institute of Cardiovascular Diseases Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether sildenafil (the drug in Viagra) can help people with severe lung high blood pressure caused by long-term rheumatic heart valve disease. Researchers will give 100 participants either sildenafil or a placebo three times daily for six weeks. The main goal is to see if the drug improves how far they can walk in six minutes.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Sildenafil (a drug that relaxes blood vessels in the lungs)
What this could lead to: If it works, this could offer a short-term treatment to improve exercise ability and heart function in people awaiting heart valve surgery.
What could go wrong: This is a small, 6-week trial, so results may not apply to long-term use. Sildenafil can cause side effects like headache, flushing, or low blood pressure.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

pulmonary hypertension rheumatic heart disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PULMONARY HYPERTENSION RHEUMATIC VALVULAR HEART DISEASE

Contacts and locations

Locations

Sindh Institute of Cardiovascular Diseases
RECRUITING

Hyderābād, Sindh, Pakistan

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