New study tracks Long-Term safety of two common PH drugs

NCT ID NCT05179876

Recruiting now Disease control Sponsor: Actelion Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jul 31, 2026 · Updated 4 times

Summary

This study follows 280 adults and children with pulmonary hypertension who are already taking macitentan or selexipag in a previous trial. The goal is to monitor long-term safety, including side effects and serious events, while allowing continued access to the medication. Participants receive their usual dose, with children getting a weight-adjusted version of macitentan.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: macitentan and selexipag
What this could lead to: If successful, this study could confirm that long-term use of these drugs is safe for managing pulmonary hypertension.
What could go wrong: This is an open-label extension study focused on safety, not on proving new benefits. Results may not apply to all patients, and side effects are still possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

pulmonary arterial hypertension pulmonary hypertension

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HYPERTENSION, PULMONARY

Contacts and locations

Locations

Abdullah, IA
COMPLETED

Durban, 4001, South Africa
Asan Medical Center
RECRUITING

Seoul, 05505, South Korea
Beijing Anzhen Hospital
RECRUITING

Beijing, 100029, China
Beijing Anzhen Hospital 1
RECRUITING

Beijing, 100029, China
Chang-Gung Memorial Hospital, LinKou Branch
RECRUITING

Taoyuan, 333, Taiwan
Children's Hospital 1
RECRUITING

Ho Chi Minh City, Vietnam
Childrens Hospital of Shanghai
RECRUITING

Shanghai, 200062, China
Chungnam National University Hospital
RECRUITING

Daejeon, 35015, South Korea
Dr Kalla
RECRUITING

Lenasia, 1820, South Africa
E.Meshalkin National Medical Research Center of the Ministry of Health of the Russian Federation
RECRUITING

Novosibirsk, 630055, Russia
Federal State Budgetary Institution
COMPLETED

Saint Petersburg, 197341, Russia
Gachon University Gil Medical Center
RECRUITING

Incheon, 21565, South Korea
Gottsegen György Országos Kardiológiai Intézet
RECRUITING

Budapest, 1096, Hungary
Hanoi Heart Hospital
RECRUITING

Hanoi, Vietnam
Hanoi Medical University Hospital
RECRUITING

Hanoi, Vietnam
Institute of Cardiology of Tomsk National Research Medical Center of Rus Academy of Sciences
COMPLETED

Tomsk, 634012, Russia
Jiangsu Province Hospital
RECRUITING

Nanjing, China
Kaohsiung Veterans General Hospital
RECRUITING

Kaohsiung City, 813, Taiwan
Klinika Kardiologii Z Oddzialem Intensywnego Nadzoru Kardiologicznego UM W Bialymstoku
RECRUITING

Bialystok, 15 276, Poland
Maharaj Nakorn Chiang Mai hospital Faculty of Medicine
RECRUITING

Chiang Mai, 50200, Thailand
Minsk Regional Clinical Hospital Of The Red Banner Of Labor
COMPLETED

Minsk, Belarus
Municipal Inst. Of Dnipropetrovsk Region. Council
COMPLETED

Dnipro, Ukraine
National Cheng Kung University Hospital
RECRUITING

Tainan, 704, Taiwan
National Taiwan University Hospital
RECRUITING

Taipei, 100, Taiwan
Oddzial Kardiologii Wojewodzki Szpital Specjalistyczny im W Bieganskiego
COMPLETED

Lodz, 91 347, Poland
Qingdao Women and Children's Hospital
RECRUITING

Qingdao, 266035, China
Regional Clinical Hospital No1
RECRUITING

Tyumen, 625000, Russia
SPSK nr 7 SUM w Katowicach Gornoslaskie Centrum Medyczne im Prof Leszka Gieca
RECRUITING

Katowice, 40 635, Poland
SPSK2 PUM Klinika Kardiologii
COMPLETED

Szczecin, 70 111, Poland
Samsung Medical Center
RECRUITING

Seoul, 06351, South Korea
Scientific and Research Institution of Cardiovascular Diseases Complex Problems
COMPLETED

Kemerovo, 650002, Russia
Seoul National University Hospital
RECRUITING

Seoul, 03080, South Korea
Seoul National University Hospital 1
RECRUITING

Seoul, 03080, South Korea
State Institute Of Phthisiology And Pulmonology N.A. F.G. Yanovskiy Of Ams Ukraine
COMPLETED

Kyiv, 03680, Ukraine
Szpital Uniwersytecki nr 2 im dr Jana Biziela w Bydgoszczy, Klinika Kardiologii
COMPLETED

Bydgoszcz, 85-168, Poland
Taipei Veterans General Hospital
RECRUITING

Taipei, 112, Taiwan
The Catholic University of Korea Seoul St Marys Hospital
COMPLETED

Seoul, 06591, South Korea
The First Affiliated Hospital of Xian Jiaotong University
RECRUITING

Xi'an, 710061, China
The Republican Scientific-Practical Center ''Cardiology''
RECRUITING

Minsk, 220036, Belarus
The Second Xiangya Hospital of Central South Hospital
RECRUITING

Changsha, 410011, China
UZ Leuven
COMPLETED

Leuven, 3000, Belgium
University Multiprofile Hospital for Active Treatment- UMHAT Sveta Anna AD
RECRUITING

Sofia, 1750, Bulgaria
Wojewodzki Szpital Specjalist Osrodek Badawczo Rozwojowy
COMPLETED

Wroclaw, 51 124, Poland
Wojewodzki Szpital Specjalistyczny im Stefana Kardynala Wyszynskiego SPZOZ
COMPLETED

Lublin, 20 718, Poland
Wojewodzki Szpital Specjalistyczny we Wroclawiu
RECRUITING

Wroclaw, 51 124, Poland

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