Breathing in a special gas could help doctors see lung damage without needles
NCT ID NCT06104228
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether inhaling a special form of xenon gas during an MRI can help doctors see and measure blood vessel changes in the lungs of people with pulmonary arterial hypertension (PAH). The goal is to find a non-invasive way to diagnose different types of PAH and track how the disease changes over time or responds to treatment. Twenty adults with PAH will be scanned at the start and after 12 months, along with standard tests like blood work and a six-minute walk.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
129Xe hyperpolarized gas
What this could lead to
If successful, 129Xe MRI could become a non-invasive way to diagnose PAH subtypes and track disease progression or treatment response without repeated invasive tests.
What could go wrong
This is a small early-phase study (20 participants) focused on imaging biomarkers, not a treatment. It may not prove that the MRI method is accurate enough for routine clinical use.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Duke University Medical Center
RECRUITINGDurham, North Carolina, 27710, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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