New drug LTP001 aims to ease rare lung condition

NCT ID NCT06649110

Recruiting now Disease control Sponsor: Novartis Pharmaceuticals Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 22, 2026 · Updated 2 times

Summary

This study tests an experimental drug called LTP001 for pulmonary arterial hypertension (PAH), a serious lung condition that makes it hard for the heart to pump blood. The trial has two parts: first, healthy volunteers receive single or multiple doses to check safety and how the drug moves through the body. Then, people with PAH receive the drug to see if it improves blood flow in the lungs and is safe. About 232 participants will take part.

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Conditions

The condition(s) this trial relates to.

pulmonary arterial hypertension

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HEALTHY VOLUNTEERS, PULMONARY ARTERIAL HYPERTENSION

Contacts and locations

Locations

Allegheny General Hospital
RECRUITING

Pittsburgh, Pennsylvania, 15212-4756, United States
Arizona Pulmonary Specialists Ltd
RECRUITING

Scottsdale, Arizona, 85258, United States
Central Florida Pulmonary Group
RECRUITING

Orlando, Florida, 32803-5734, United States
Emory University School of Medicine
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Atlanta, Georgia, 30322, United States
Lahey Hospital and Medical Center
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Burlington, Massachusetts, 01805, United States
Norton Infectious Diseases Specialists
RECRUITING

Louisville, Kentucky, 40202, United States
Novartis Investigative Site
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Buenos Aires, Buenos Aires F.D., 1199, Argentina
Novartis Investigative Site
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CABA, C1426ABP, Argentina
Novartis Investigative Site
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Río Cuarto, X5800AEV, Argentina
Novartis Investigative Site
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San Miguel de Tucumán, T4000AXL, Argentina
Novartis Investigative Site
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Santa Fe, S3000EOZ, Argentina
Novartis Investigative Site
RECRUITING

Camperdown, New South Wales, 2050, Australia
Novartis Investigative Site
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Darlinghurst, New South Wales, 2010, Australia
Novartis Investigative Site
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New Lambton Heights, New South Wales, 2305, Australia
Novartis Investigative Site
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Adelaide, South Australia, 5000, Australia
Novartis Investigative Site
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Leuven, Vlaams Brabant, 3000, Belgium
Novartis Investigative Site
RECRUITING

Porto Alegre, Rio Grande do Sul, 90035-074, Brazil
Novartis Investigative Site
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Prague, 128 08, Czechia
Novartis Investigative Site
RECRUITING

Prague, 14021, Czechia
Novartis Investigative Site
RECRUITING

Angers, France, 49933, France
Novartis Investigative Site
RECRUITING

Brest, 29200, France
Novartis Investigative Site
RECRUITING

Clamart, 92141, France
Novartis Investigative Site
RECRUITING

Grenoble, 38043, France
Novartis Investigative Site
RECRUITING

Montpellier, 34295, France
Novartis Investigative Site
RECRUITING

Nice, 06001, France
Novartis Investigative Site
RECRUITING

Pessac, 33604, France
Novartis Investigative Site
RECRUITING

Poitiers, 86021, France
Novartis Investigative Site
RECRUITING

Saint-Priest-en-Jarez, 42270, France
Novartis Investigative Site
RECRUITING

Strasbourg, 67091, France
Novartis Investigative Site
RECRUITING

Toulouse, 31059, France
Novartis Investigative Site
RECRUITING

Vandœuvre-lès-Nancy, 54511, France
Novartis Investigative Site
RECRUITING

Regensburg, Bavaria, 93053, Germany
Novartis Investigative Site
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Dresden, Saxony, 01307, Germany
Novartis Investigative Site
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Berlin, 13125, Germany
Novartis Investigative Site
RECRUITING

Berlin, 14050, Germany
Novartis Investigative Site
RECRUITING

Giessen, 35392, Germany
Novartis Investigative Site
RECRUITING

Greifswald, 17475, Germany
Novartis Investigative Site
RECRUITING

Heidelberg, 69120, Germany
Novartis Investigative Site
RECRUITING

Homburg, 66421, Germany
Novartis Investigative Site
RECRUITING

Athens, 106 76, Greece
Novartis Investigative Site
RECRUITING

Chaïdári, 124 62, Greece
Novartis Investigative Site
RECRUITING

Thessaloniki, 54636, Greece
Novartis Investigative Site
RECRUITING

Foggia, FG, 71122, Italy
Novartis Investigative Site
RECRUITING

Monza, MB, 20900, Italy
Novartis Investigative Site
RECRUITING

Palermo, PA, 90127, Italy
Novartis Investigative Site
RECRUITING

Pavia, PV, 27100, Italy
Novartis Investigative Site
RECRUITING

Roma, RM, 00161, Italy
Novartis Investigative Site
RECRUITING

Sassari, SS, 07100, Italy
Novartis Investigative Site
RECRUITING

Ivrea, TO, 10015, Italy
Novartis Investigative Site
RECRUITING

Trieste, TS, 34149, Italy
Novartis Investigative Site
RECRUITING

Riga, LV 1002, Latvia
Novartis Investigative Site
RECRUITING

Monterrey, Nuevo León, 64460, Mexico
Novartis Investigative Site
RECRUITING

Monterrey, Nuevo León, 64718, Mexico
Novartis Investigative Site
RECRUITING

San Luis Potosí City, San Luis Potosí, 78200, Mexico
Novartis Investigative Site
RECRUITING

Poznan, 61 545, Poland
Novartis Investigative Site
RECRUITING

Almada, 2805-267, Portugal
Novartis Investigative Site
RECRUITING

Lisbon, 1769 001, Portugal
Novartis Investigative Site
RECRUITING

Timișoara, Timiș County, 300310, Romania
Novartis Investigative Site
RECRUITING

Bucharest, 050159, Romania
Novartis Investigative Site
RECRUITING

Belgrade, Serbia, 11000, Serbia
Novartis Investigative Site
RECRUITING

Kamenitz, 21204, Serbia
Novartis Investigative Site
RECRUITING

Niš, 18108, Serbia
Novartis Investigative Site
RECRUITING

Santiago Compostela, A Coruna, 15706, Spain
Novartis Investigative Site
RECRUITING

Marbella, Andalusia, 29600, Spain
Novartis Investigative Site
RECRUITING

Toledo, Castille-La Mancha, 45071, Spain
Novartis Investigative Site
RECRUITING

Barcelona, Catalonia, 08003, Spain
Novartis Investigative Site
RECRUITING

Las Palmas de Gran C, Las Palmas, 35016, Spain
Novartis Investigative Site
RECRUITING

Barcelona, 08035, Spain
Novartis Investigative Site
RECRUITING

Seville, 41013, Spain
Novartis Investigative Site
RECRUITING

Sheffield, South Yorkshire, S10 2JF, United Kingdom
Novartis Investigative Site
RECRUITING

Cambridge, CB2 0AY, United Kingdom
Novartis Investigative Site
RECRUITING

London, EC1A 7BE, United Kingdom
Novartis Investigative Site
RECRUITING

London, SW3 6PH, United Kingdom
PPD Development LP
RECRUITING

Austin, Texas, 78744, United States
PPD Development LP
RECRUITING

Austin, Texas, 78744, United States
Pul Ass Richmond Inc P A R
RECRUITING

Richmond, Virginia, 23230-1709, United States
Sky Integrative Medical Center SKYCRNG PPDS
RECRUITING

Ridgeland, Mississippi, 39157-5179, United States
Stanford Medical Center
RECRUITING

Stanford, California, 94305, United States
Statcare Pulmonary Consultants
RECRUITING

Knoxville, Tennessee, 37919, United States
Summit Health Eastside Clinic
RECRUITING

Bend, Oregon, 97701, United States
The University of Utah
RECRUITING

Salt Lake City, Utah, 84132-0001, United States
Tufts Medical Center
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Boston, Massachusetts, 02111, United States
U of Kansas Medical Center
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Kansas City, Kansas, 66160, United States
UC Irvine Medical Center
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Orange, California, 92868-3298, United States
UT Southwestern Medical Center
RECRUITING

Dallas, Texas, 75390, United States
Univ Colorado Hospital
RECRUITING

Aurora, Colorado, 80045, United States
University of South Florida
RECRUITING

Tampa, Florida, 33606-3475, United States