Can a scan predict radiation harm to heart and lungs?

NCT ID NCT04901884

Recruiting now Knowledge-focused Sponsor: University Health Network, Toronto Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study is looking for early signs of heart and lung damage in people receiving radiation for chest cancers. Researchers will use PET/MR scans and blood tests before and after treatment to see if they can predict who will develop problems like pulmonary hypertension. The goal is to find better ways to monitor and eventually prevent these side effects.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: 18F-FDG (a radioactive tracer used in PET scans)
What this could lead to: If successful, this could help doctors identify patients at risk of heart or lung damage from chest radiation earlier, potentially guiding personalized follow-up care.
What could go wrong: This is a small, early exploratory study with only 40 participants. It is not testing a treatment, so it may not lead to any direct benefit for patients. The markers studied may not prove reliable in larger groups.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

pulmonary hypertension thoracic cancer

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PULMONARY HYPERTENSION

Contacts and locations

Locations

University Health Network
RECRUITING

Toronto, Ontario, M5G 2M9, Canada

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