Could less treatment be better? new study questions routine use of inhaled nitric oxide in CDH babies
NCT ID NCT05213676
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study looks at whether not using inhaled nitric oxide (iNO) in newborns with congenital diaphragmatic hernia (CDH) leads to better outcomes, like fewer needing life support or dying. About 600 babies from multiple hospitals will be included. The goal is to see if stopping this routine treatment is safe, effective, and saves money.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Emory University & Children's Healthcare of Atlanta (CHOA)
RECRUITINGAtlanta, Georgia, 30322, United States
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Harvard University & Boston Children's Hospital (Harvard-BCH)
RECRUITINGBoston, Massachusetts, 02115, United States
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Indiana University & Riley Children's Hospital (IU-RiCH)
RECRUITINGIndianapolis, Indiana, 46202, United States
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Medical University of South Carolina Children's Health (MUSC)
RECRUITINGCharleston, South Carolina, 29425, United States
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Randall Children's Hospital-Portland (RCH)
RECRUITINGPortland, Oregon, 97227, United States
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Stanford University & Lucile Packard Children's Hospital (Stanford-LPCH)
RECRUITINGPalo Alto, California, 94304, United States
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The University of Texas Health Science Center at Houston
RECRUITINGHouston, Texas, 77030, United States
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University of Alabama & Children's Hospital of Alabama (UAB-CoA)
RECRUITINGBirmingham, Alabama, 35233, United States
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University of Arkansas & Arkansas Children's Hospital (UA-ACH)
RECRUITINGLittle Rock, Arkansas, 72202, United States
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University of California, San Diego & Rady Children's Hospital (UCSD-Rady)
RECRUITINGSan Diego, California, 92123, United States
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University of California-Irvine & Children's Hospital of Orange County (UC-CHOC)
RECRUITINGIrvine, California, 92868, United States
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University of Colorado & Children's Hospital of Colorado (CU-CHC)
RECRUITINGAurora, Colorado, 80045, United States
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University of Louisville & Norton Children's Hospital (UL-NCH)
RECRUITINGLouisville, Kentucky, 40202, United States
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University of Michigan & CS Mott Children's Hospital (UM-CSMott)
RECRUITINGAnn Arbor, Michigan, 48109, United States
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University of Southern California & Children's Hospital Los Angeles (USC-CHLA)
RECRUITINGLos Angeles, California, 90027, United States
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University of Tennessee & LeBonheur Children's Hospital (UT-LBCH)
RECRUITINGMemphis, Tennessee, 38105, United States
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University of Utah & Primary Children's Hospital (Utah-PCH)
RECRUITINGSalt Lake City, Utah, 84108, United States
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University of Washington & Seattle Children's Hospital (UW-SCH)
RECRUITINGSeattle, Washington, 98105, United States
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Vanderbilt University & Vanderbilt University Medical Center (VUMC)
RECRUITINGNashville, Tennessee, 37232, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Can 3D models bring a Baby's birth defect into focus before birth?
- Can a tiny balloon in the womb save babies born with a hole in their diaphragm?
- Tiny balloon inside womb could help babies breathe
- Teens' sports struggles after rare birth defect surgery: study seeks answers
- New trial could change how doctors help CDH babies at birth
- Pioneering fetal surgery aims to save babies born with a hole in their diaphragm