New scan could spot hidden scarring in heart and lungs before It's too late

NCT ID NCT07613099

First seen Jun 25, 2026 · Last updated Aug 14, 2026 · Updated 35 times

Summary

This study tests a new radioactive tracer called 18F-FAPI-74 that may help detect scar tissue (fibrosis) in the heart and lungs earlier than current methods. Researchers will compare this new PET/CT scan to standard imaging in 210 adults with conditions like lung disease or heart problems. The goal is to see if the tracer can identify active scarring, which could lead to earlier treatment and better monitoring of disease progression.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
18F-FAPI-74 (a radioactive tracer for PET/CT scans)
What this could lead to
If successful, this could lead to a better way to detect scarring early in heart and lung diseases, allowing doctors to start treatment sooner and track disease progression more accurately.
What could go wrong
This is an early-stage imaging study, not a treatment. The tracer may not prove more effective than current scans, and results may not apply to all patients.

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • National Institutes of Health Clinical Center

    RECRUITING

    Bethesda, Maryland, 20892, United States

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