INTERSTITIAL LUNG DISEASE

This study is testing whether a new once-daily inhaled powder (TPIP) can help adults who have pulmonary hypertension caused by scarred lungs (interstitial lung disease). Over 300 participants will use either the real powder or a placebo for 24 weeks to see if it improves how far …

This study is testing whether hydroxychloroquine, a medication used for malaria and autoimmune diseases, can help children with rare genetic lung disorders breathe easier. Researchers will compare children who receive the drug to those who don't to see if it improves oxygen level…

This study is testing an oral drug called H01 (hymecromone) in adults with progressive interstitial lung disease, a condition that causes scarring and thickening of lung tissue. The main goal is to see if H01 can reduce levels of a substance called hyaluronan in the blood, which …

This study is testing a stem cell transplant procedure for people with severe systemic sclerosis (scleroderma) that hasn't responded to other treatments. Doctors will use the patient's own filtered stem cells to try to 'reset' their faulty immune system after strong chemotherapy.…

This study is testing if a newer drug called Telitacicept is better and safer than the standard treatment, Cyclophosphamide, for controlling lung scarring in people with early lupus. It will involve 100 adults who have both lupus and signs of lung disease. The main goal is to see…

This large, late-stage study is testing whether an inhaled medication called treprostinil can safely slow the progression of lung scarring (progressive pulmonary fibrosis) in adults. About 700 participants will use either the drug or a placebo inhaler four times a day for one yea…

This study is testing if the drug abatacept can help control a serious lung disease that occurs in people with common variable immunodeficiency (CVID), a rare disorder where the immune system doesn't work properly. Researchers will compare abatacept to a placebo (inactive substan…

This study is testing whether a drug called BIO 300 can help protect the lungs of patients who have both early-stage lung cancer and a separate lung scarring disease (interstitial lung disease) when they receive radiation therapy. The main goal is to see if BIO 300 can prevent se…

This study is testing whether a new artificial intelligence (AI) tool can help doctors more completely diagnose the many complications that can occur with rheumatoid arthritis (RA), such as lung, heart, or thyroid problems. Researchers will give doctors AI-generated predictions a…

This study is testing if a quick, non-invasive eye exam called capillaroscopy can help doctors diagnose the cause of a scarring lung disease faster. Researchers will give the exam to 48 adults newly diagnosed with interstitial lung disease. The goal is to see if this test helps i…

This study is testing a new type of MRI scan that uses a safe, inhaled gas called xenon to create detailed pictures of how the lungs are working. Researchers want to see if this method, which doesn't use radiation, can better detect and monitor lung diseases like pulmonary fibros…

This study aims to develop a non-invasive MRI scan to identify patients with certain lung diseases and high blood pressure in the lungs who might respond to specific medications. Researchers will use a special gas-based MRI scan on 30 patients with conditions like COPD or pulmona…

This study aims to find the best combination of tests to spot pulmonary hypertension (high blood pressure in the lungs) earlier in people who have interstitial lung disease (scarring of the lungs). Researchers will gather detailed health information from 300 participants through …

This study is testing a mobile app called SUPPORT-T to see if it's a practical and helpful way to deliver supportive care to people with progressive pulmonary fibrosis (a scarring lung disease) and their caregivers. The app provides a 9-week guided program and virtual support gro…

This study is testing if two existing medications, duloxetine and amitriptyline, can reduce the frequency and severity of chronic cough in people with interstitial lung disease (ILD). It will involve about 25 participants who will try different doses of the medications or a place…

This study is testing if two existing medications can help prevent severe shortness of breath in people with lung cancer and a pre-existing lung scarring disease (ILD) who need radiation therapy. About 98 participants will be randomly assigned to receive either the drugs (N-acety…

This study is looking at whether adding special breathing muscle training to standard breathing exercises helps people with rheumatoid arthritis who also have lung disease. Researchers will compare two groups of 39 patients to see if the extra training improves their ability to e…

This study is creating a large collection of health information and biological samples from people with various scarring lung diseases. Researchers will use this 'biobank' to look for patterns, risk factors, and potential targets for future treatments. The goal is to better under…

This study aims to better understand a serious condition where high blood pressure develops in the lungs due to underlying lung scarring. Researchers will follow 1,000 patients for up to 5 years to track their health, treatments, and quality of life. The goal is to gather real-wo…

This study aims to see how reliable automated computer tools are at measuring the amount of scarring in the lungs from CT scans. Researchers will test this by having 150 patients with interstitial lung disease get two CT scans on the same day and using different software to analy…

This study aims to see if advanced MRI scans can detect areas of low oxygen in the lungs of people with early-stage idiopathic pulmonary fibrosis (IPF), a serious scarring disease. Researchers will scan 50 participants to see if these oxygen maps can identify patients who might b…

This study aims to better understand the signals seen on lung ultrasound scans in people with chronic lung diseases like COPD and interstitial lung disease. Researchers will collect ultrasound images and breathing data from 25 hospitalized and outpatient participants to learn how…

This study aims to learn more about how new treatments work for patients with a serious lung disease that also causes high blood pressure in the lungs. Researchers will look for changes in blood and urine chemicals before and during treatment. The goal is to understand the body's…

This study is testing a new type of MRI scan that uses a safe, inhaled gas to create detailed pictures of how well the lungs transfer oxygen to the blood. Researchers want to see how these pictures change in people with various lung and blood conditions, and in healthy volunteers…

This study aims to better understand and predict how certain lung scarring diseases get worse over time. Researchers will follow 500 adults with specific types of lung scarring for two years, collecting health data and blood samples. The goal is to improve how doctors classify an…

This study collects blood and tissue samples from people with advanced lung diseases or who have had lung transplants. Researchers will store these samples in a biobank to study them later, looking for biological markers that could help diagnose conditions earlier or predict how …