INTERSTITIAL LUNG DISEASE

This study tests if hydroxychloroquine, a medicine used for malaria and some immune conditions, can improve breathing in children with a rare genetic lung disease. About 60 children under 18 with a confirmed genetic cause will be randomly assigned to receive the drug or not. Rese…

This study compares a newer drug, telitacicept, to the standard treatment cyclophosphamide for lung scarring (interstitial lung disease) caused by lupus. About 100 adults with early lupus and mild-to-moderate lung involvement will receive one of the two drugs for a year. The goal…

This study tests an inhaled powder called treprostinil palmitil for people with high blood pressure in the lungs caused by scarring lung disease. About 344 adults will receive either the drug or a placebo once daily for 24 weeks. The main goal is to see if the drug helps them wal…

This phase 3 study tests whether an inhaled medication called treprostinil can slow the worsening of lung function in people with progressive pulmonary fibrosis (PPF), a condition where lung scarring gets worse over time. About 698 adults with PPF will receive either the drug or …

This study tests an oral drug called H01 (hymecromone) in 37 adults with interstitial lung disease, a condition that causes lung scarring and often leads to death within 3-5 years. Participants take the drug twice daily for 12 weeks. The goal is to see if H01 can lower a marker o…

This study tests a stem cell transplant for people aged 8-24 with severe systemic sclerosis (scleroderma) that hasn't improved with standard treatments. The goal is to see if this approach is safer and still controls the disease. Participants receive high-dose therapy to reset th…

This study tests an inhaled version of the drug pirfenidone (AP01) in 375 adults with progressive pulmonary fibrosis, a condition where lung scarring worsens over time. Participants receive either a high dose, low dose, or placebo twice daily for 52 weeks, alongside their usual c…

This study tests whether combining two drugs, nintedanib and tocilizumab, works better than standard treatments for people with systemic sclerosis (scleroderma) who also have lung scarring. About 86 adults will receive either the combination or usual care for 56 weeks. The main g…

This study tests if abatacept can improve lung disease in people with common variable immunodeficiency (CVID). About 38 children and adults will receive either abatacept or a placebo for 6 months. The main goal is to see if the drug reduces lung damage seen on CT scans.

This study tests whether adding BIO 300 to standard chest radiation can prevent severe lung inflammation (pneumonitis) in people with early-stage non-small cell lung cancer who also have interstitial lung disease (lung scarring). About 25 adults will receive the combination and b…

This study is testing a special PET scan that uses a radioactive tracer to find collagen buildup in the lungs, which is an early sign of scarring. Researchers will compare scans from healthy relatives of people with pulmonary fibrosis and from patients with early lung abnormaliti…

This study looks at whether a quick, radiation-free lung ultrasound can detect interstitial lung disease (ILD) in people with rheumatoid arthritis. ILD is a serious complication that can be deadly, but current detection relies on expensive CT scans. Researchers will compare ultra…

This small pilot study is testing whether semaglutide, a drug already approved for diabetes and obesity, is safe and tolerable for people with advanced lung diseases like COPD or pulmonary fibrosis. Eight participants will take the drug for 12 weeks while researchers monitor side…

This study is testing a mobile app called SUPPORT-T that helps people with progressive pulmonary fibrosis (a type of lung scarring) and their caregivers get palliative care support at home. The app includes a 9-week guided program and virtual support groups over a year. Researche…

This study tests whether two drugs—N-acetyl cysteine and a short course of dexamethasone—can reduce severe shortness of breath after lung radiation in people with both lung cancer and interstitial lung disease. About 98 participants will receive either the drugs or placebos. The …

This study tests whether two common nerve pain medications, duloxetine and amitriptyline, can reduce coughing in people with interstitial lung disease (ILD). About 25 adults with a chronic cough lasting at least 3 months will receive either a low or high dose of one drug or a pla…

This study looks at why people with interstitial lung disease (ILD) often feel short of breath and have trouble exercising. Researchers think leg muscle problems might be a cause. They will measure leg muscle strength and structure in 40 adults with ILD, and test whether extra ox…

This study looks at whether generative AI can help doctors better diagnose complications of rheumatoid arthritis (RA), such as lung disease or heart problems. Researchers will use AI to analyze patient records and suggest possible complications, then see if doctors find these sug…

This study looks at 750 adults with rheumatoid arthritis (RA) who are at risk for developing interstitial lung disease (ILD). Researchers use chest CT scans and track changes over 3-5 years to find early signs and risk factors. The goal is to better understand who might develop l…

This study is looking for early warning signs that lung scarring (fibrosis) is getting worse in people with various types of interstitial lung disease. Researchers will follow 450 adults over time, using blood tests, breathing tests, CT scans, and breath analysis to find markers …

This study is collecting blood samples from people with interstitial lung disease (ILD) to create a repository for future research. The goal is to find biomarkers that could help guide treatment. Both ILD patients and healthy volunteers are needed.

This study is testing a new type of MRI that uses a special gas (xenon) to take detailed pictures of lung function. It will include 260 healthy volunteers and people with various lung diseases like asthma, COPD, and cystic fibrosis. The goal is to see if this imaging method can b…

This study is creating a registry and biobank for people with interstitial lung disease (ILD), including sarcoidosis, pulmonary fibrosis, and hypersensitivity pneumonitis. Researchers will collect medical data and biological samples from up to 1,000 participants to better underst…

This study is testing a new MRI technique that uses a special gas called 129Xe to take detailed pictures of how the lungs work. It includes both healthy volunteers and people with lung disease. The goal is to see if this method can safely and effectively show lung function, inclu…

This study collects blood and tissue samples from 100 adults who have had a lung transplant in the last 10 years. Researchers will use these samples to study biomarkers and how infections affect outcomes. The goal is to improve care for people with advanced lung disease, not to t…

This study uses a special MRI that tracks a harmless gas (129Xe) to see how well the lungs and heart exchange oxygen. Researchers will scan healthy people and those with lung disease, anemia, or blood clots to understand how these conditions affect breathing. The goal is to devel…

This study aims to find better ways to detect lung scarring (interstitial lung disease) early in people with connective tissue diseases like scleroderma or rheumatoid arthritis. Researchers will analyze tiny particles in the blood and use AI to examine lung scans from 200 partici…

This study is a patient registry that will collect information from 900 adults with both pulmonary hypertension (high blood pressure in the lungs) and interstitial lung disease (scarring of the lungs). The goal is to better understand the patients' health history and how their co…

This study looks at how immunosuppression treatment changes lung scarring in people with certain types of interstitial lung disease (not IPF). Researchers will use special PET and MRI scans to measure collagen buildup and tissue damage. The goal is to better understand the diseas…

This study looks at whether adding a simple microscope test of the tiny blood vessels at the base of the fingernails (capillaroscopy) can help doctors diagnose a type of lung disease called interstitial lung disease (PID) that is linked to connective tissue diseases (like lupus o…

This study uses advanced MRI scans to look at oxygen levels in the lungs of people with early-stage idiopathic pulmonary fibrosis (IPF), a type of lung scarring. The goal is to see if MRI can find areas with low oxygen, which might help doctors identify patients who could benefit…

This study looks at whether adding breathing muscle training to standard rehab helps people with rheumatoid arthritis who also have lung disease. Researchers will measure changes in exercise ability, breathlessness, and a specific gene (HOTAIR) linked to inflammation. About 39 ad…

This study follows 500 adults with progressive pulmonary fibrosis (a type of lung scarring) for 24 months. Researchers will collect medical data, images, and samples to better understand the disease and improve how it is classified and predicted. No new treatments are tested; the…

This study aims to see if automated computer tools can consistently measure the amount of lung scarring (interstitial lung disease) on chest CT scans. Researchers will enroll 150 adults with known lung disease and repeat their CT scans to check if the measurements are reliable. T…

This study aims to understand how treatments for pulmonary hypertension (PH) affect people with lung fibrosis. Researchers will analyze blood and urine samples from 80 participants before and during treatment to find chemical markers that show who responds well. The goal is to be…

This study aims to find a noninvasive way to detect changes in lung blood vessels in people with a type of pulmonary hypertension (Group 3 PH) caused by lung diseases like COPD or interstitial lung disease. Researchers will use a special MRI technique (hyperpolarized 129Xe MRI) t…

This study looks at whether giving extra oxygen during a 6-minute walk test helps people with chronic lung disease walk farther and feel better. About 114 adults with conditions like COPD or lung scarring will do two walking tests—one with their usual oxygen and one with extra ox…

This study aims to better understand the patterns seen on lung ultrasound scans in people with chronic lung diseases. Researchers will enroll 25 adult patients with conditions like COPD or interstitial lung disease. They will compare ultrasound images with other breathing measure…