Inhaled treprostinil aims to slow lung decline in fibrosis trial

NCT ID NCT05943535

Recruiting now Disease control Sponsor: United Therapeutics Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jul 14, 2026 · Updated 4 times

Summary

This phase 3 study tests whether an inhaled drug called treprostinil can slow the worsening of lung function in people with progressive pulmonary fibrosis, a condition where lung scarring gets worse over time. About 698 adults will receive either the drug or a placebo four times daily for 52 weeks. The main goal is to see if the drug helps maintain the amount of air they can exhale forcefully.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Inhaled treprostinil (Tyvaso)
What this could lead to: If it works, this could provide a new treatment to slow lung function decline and reduce hospitalizations in people with progressive pulmonary fibrosis.
What could go wrong: This is a phase 3 trial, but the drug may not prove effective or could cause side effects like cough or headache. Results may not apply to all forms of lung fibrosis.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

interstitial lung disease pulmonary fibrosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

INTERSTITIAL LUNG DISEASE PROGRESSIVE PULMONARY FIBROSIS

Contacts and locations

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Study contacts

Contact

Email: •••••@•••••

Locations

A & A Research Consultants, LLC
RECRUITING

McAllen, Texas, 78503, United States
AZORG
RECRUITING

Aalst, 9300, Belgium
Adventist Healthcare White Oak Medical Center
RECRUITING

Silver Spring, Maryland, 20904, United States
Aotearoa Clinical Trials Trust- Middlemore Hospital
RECRUITING

Auckland, New Zealand
Asan Medical Center
RECRUITING

Seoul, 05505, South Korea
Ascension Medical Group St. Vincent's Lung Institute
RECRUITING

Jacksonville, Florida, 32204, United States
Assistance Publique Hôpitaux de Marseille - centre Hospitalier Régional de Marseille
RECRUITING

Marseille, France
Austin Health
RECRUITING

Heidelberg, Victoria, 3084, Australia
Azienda Ospedaliero Universitaria Policlinico "G. Rodolico - San Marco" Presidio Ospedaliero Gaspare Rodolico
RECRUITING

Catania, 95123, Italy
Azienda Ospedaliero-Universitaria Senese
RECRUITING

Siena, 53100, Italy
Azienda Ospedaliero-Universitaria di Modena Policlinico di Modena
RECRUITING

Modena, 41124, Italy
Azienda Unita Sanitaria Locale Della Romagna Ospedale "Gian Battista Morgagni - Luigi Pierantoni" di Forlì
RECRUITING

Forlì, 47121, Italy
Banner University Medical Center Phoenix Lung Institute
RECRUITING

Phoenix, Arizona, 85006, United States
Barzilai Medical Center
RECRUITING

Ashkelon, 7830604, Israel
Baylor University Medical Center
RECRUITING

Dallas, Texas, 75246, United States
Beaumont Hospital, Royal Oak
RECRUITING

Royal Oak, Michigan, 48073, United States
Biocinetic Ltda.
RECRUITING

Santiago, Santiago Metropolitan, 8320000, Chile
Birmingham Heartlands Hospital
RECRUITING

Birmingham, United Kingdom
CEC Centro Estudios Clinicos
RECRUITING

Santiago, Santiago Metropolitan, 7550495, Chile
CHU Caen Normandie
RECRUITING

Caen, 14000, France
CHU de Liège
RECRUITING

Liège, 4000, Belgium
CIC Mauricie inc.
RECRUITING

Québec, Quebec, G8T 7A1, Canada
CIMER-Centro Integral de Medicina Respiratoria
RECRUITING

San Miguel de Tucumán, Tucumán Province, Argentina
CINME Centro de Investigaciones Metabolicas
RECRUITING

Buenos Aires, C1056ABI, Argentina
CUB Hopital Erasmde
RECRUITING

Brussels, 1070, Belgium
Canterbury Respiratory Research Group
RECRUITING

Christchurch, Canterbury, 8011, New Zealand
Centre Hospitalier Régional Universitaire de Tours
RECRUITING

Tours, Tours Cedex 9, France
Centro Respiratorio Integral LTDA. (CENRESIN)
RECRUITING

Quillota, Valparaiso, 2260000, Chile
Centro Ricerche Cliniche di Verona SrL Pneumology Unit
RECRUITING

Verona, 37134, Italy
Centro de Investigacion Curico
RECRUITING

Curicó, Maule Region, 3341643, Chile
Centro de Investigacion de Enfermedades Respiratorias - Clinica Providencia
RECRUITING

Lima, 15088, Peru
Centro de Investigación de Enfermedades Respiratorias e Inmunológicas (CIERI)
RECRUITING

Viña del Mar, Valparaiso, 2520000, Chile
Chang Gung Medical Foundation Kaohsiung Chang Gung Memorial Hospital
RECRUITING

Kaohsiung City, 83301, Taiwan
Christopher King, MD
RECRUITING

Falls Church, Virginia, 22042, United States
Cleveland Clinic Florida
RECRUITING

Weston, Florida, 33331, United States
Clinica Internacional - Sede Lima
RECRUITING

Lima, 15001, Peru
Clinica Ricardo Palma
RECRUITING

Lima, 15036, Peru
Clinical Trials Center of Middle Tennessee, LLC
RECRUITING

Franklin, Tennessee, 37067, United States
Cliniques Universitaires St.-Luc
RECRUITING

Brussels, 1200, Belgium
Corewell Health Grand Rapids Hospitals - Butterworth
RECRUITING

Grand Rapids, Michigan, 49503, United States
Diex Recherche Inc. - Division Sherbrooke Est
RECRUITING

Sherbrooke, Quebec, J1E 0N8, Canada
Duke University Medical Center
RECRUITING

Durham, North Carolina, 27710, United States
Dynamic Drug Advancement Limited
RECRUITING

Ajax, Ontario, L1S 2J5, Canada
East Carolina University
RECRUITING

Greenville, North Carolina, 27834, United States
Eastern Health Box Hill Hospital
RECRUITING

Box Hill, Victoria, 3128, Australia
Fondazione IRCCS San Gerardo dei Tintori
RECRUITING

Monza, Italy
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
RECRUITING

Roma, 168, Italy
Fundacion Medica San Cristobal
RECRUITING

Santiago, Santiago Metropolitan, 7630226, Chile
Fundación Respirar
RECRUITING

Buenos Aires, C1426ABP, Argentina
Gachon University Gil Medical Center
RECRUITING

Incheon, 21565, South Korea
Georgetown University Hospital
RECRUITING

Washington D.C., District of Columbia, 20007, United States
Guy's Hospital
RECRUITING

London, SE1 9RT, United Kingdom
Hillel Yaffe Medical Center
RECRUITING

Hadera, 3846201, Israel
Hospices civils de Lyon - Hôpital Louis Pradel
RECRUITING

Bron, 69500, France
Hospital Central de la Fuerza Aerea del Peru
RECRUITING

Lima, 15046, Peru
Hospital Nacional Adolfo Guevara Velasco
RECRUITING

Cusco, 08002, Peru
Hospital of the University of Pennsylvania
RECRUITING

Philadelphia, Pennsylvania, 19104, United States
Houston Methodist Outpatient Center
RECRUITING

Houston, Texas, 77030, United States
Hôpital Avicennes
RECRUITING

Bobigny, 93000, France
Hôpital Maisonneuve-Rosemont
RECRUITING

Montreal, Quebec, H1T 2M4, Canada
Infinity Medical Center
RECRUITING

North Dartmouth, Massachusetts, 02747, United States
Institute for Respiratory Health
RECRUITING

Nedlands, Western Australia, 6009, Australia
Institute for Respiratory Health - Midland
RECRUITING

Midland, Western Australia, 6056, Australia
Instituto Ave Pulmo - Fundacion enfisema
RECRUITING

Mar del Plata, Buenos Aires, 7600, Argentina
Instituto Medico Rio Cuarto
RECRUITING

Río Cuarto, Córdoba Province, 5800, Argentina
Instituto de Medicina Respiratoria
RECRUITING

Córdoba, 5003, Argentina
Intermountain Medical Center
RECRUITING

Murray, Utah, 84107, United States
Investigaciones en Patologias Respiratorias
RECRUITING

San Miguel de Tucumán, Tucumán Province, 4000, Argentina
Jefferson Honickman Center
RECRUITING

Philadelphia, Pennsylvania, 19107, United States
Johns Hopkins Asthma and Allergy Center
RECRUITING

Baltimore, Maryland, 21224, United States
Kaohsiung Medical University Chung-Ho Memorial Hospital
RECRUITING

Kaohsiung City, 807, Taiwan
Kaplan Medical Center
RECRUITING

Rehovot, 7551041, Israel
Korea University Anam Hospital
RECRUITING

Seoul, 02841, South Korea
LMU Klinikum Medizinische Klinik und Poliklinik V
RECRUITING

München, 81377, Germany
Loyola University Medical Center
RECRUITING

Maywood, Illinois, 60153, United States
Lung Research QLD
RECRUITING

Chermside, Queensland, 4032, Australia
Lungenfachklinik Immenhausen
RECRUITING

Immenhausen, 34376, Germany
Manchester University NHS Foundation Trust, North Manchester General Hospital
RECRUITING

Manchester, M8 5RB, United Kingdom
Massachusetts General Hospital
RECRUITING

Boston, Massachusetts, 02114, United States
Mayo Clinic
RECRUITING

Jacksonville, Florida, 32224, United States
Mayo Clinic
RECRUITING

Rochester, Minnesota, 55905, United States
Medical College of Wisconsin
RECRUITING

Milwaukee, Wisconsin, 53226-1222, United States
Medical University of South Carolina-Nexus
RECRUITING

Charleston, South Carolina, 29425, United States
Medizinische Hochschule Hannover
RECRUITING

Hanover, Lower Saxony, 30625, Germany
Meir Medical Center
RECRUITING

Kfar Saba, 4428164, Israel
Memorial Hospital at Gulfport
RECRUITING

Gulfport, Mississippi, 39501, United States
Mercy Health St.Vincent Medical Center LLC
RECRUITING

Toledo, Ohio, 43608, United States
Methodist Hospital
RECRUITING

San Antonio, Texas, 78229, United States
Metroplex Pulmonary and Sleep Center
RECRUITING

McKinney, Texas, 75069, United States
Monash Health-Monash Medical Centre
RECRUITING

Clayton, Victoria, 3168, Australia
Montefiore Medical Center
RECRUITING

The Bronx, New York, 10467, United States
NHS Lothian, Royal INfirmary of Edingburgh
RECRUITING

Edinburgh, EH16 4SA, United Kingdom
NHS Tayside, Perth Royal Infirmary
RECRUITING

Perth, PH1 1NX, United Kingdom
NewportNativeMD, Inc.
RECRUITING

Newport Beach, California, 92663, United States
Northwell Health
RECRUITING

New Hyde Park, New York, 11042, United States
Northwestern Memorial Hospital, Clinical Research Unit
RECRUITING

Chicago, Illinois, 60611, United States
Norton Thoracic Institute
RECRUITING

Phoenix, Arizona, 85013, United States
Paradigm Clinical Research
RECRUITING

Redding, California, 45227, United States
Paradigm Clinical Research
RECRUITING

San Diego, California, 92108, United States
Pennsylvania State Hershey Medical Center and College of Medicine
RECRUITING

Hershey, Pennsylvania, 17033, United States
Peter Morton Medical Building
RECRUITING

Los Angeles, California, 90095, United States
Prisma Health Pulmonology-Richland
RECRUITING

Columbia, South Carolina, 29203, United States
Prufstelle der GWT am Fachkrankenhaus Coswig
RECRUITING

Coswig, 01640, Germany
PulmonIx LLC
RECRUITING

Greensboro, North Carolina, 27403, United States
Pulmonary Associates of Richmond, Inc.
RECRUITING

Richmond, Virginia, 23230, United States
Rabin Medical Center
RECRUITING

Haifa, 3436212, Israel
Rabin Medical Center
RECRUITING

Petah Tikva, 4941492, Israel
RoMed Klinikum Rosenheim-Ellmaierstr. 23
RECRUITING

Rosenheim, Bavaria, 83022, Germany
Rouen University Hospital
RECRUITING

Rouen, 7600, France
Royal Papworth Hospital
RECRUITING

Cambridge, CB2 0AY, United Kingdom
Royal Prince Alfred Hospital
RECRUITING

Camperdown, New South Wales, 2050, Australia
Royal University Hospital
RECRUITING

Saskatoon, Saskatchewan, S7N 0W8, Canada
Rush University Medical Center Outpatient Pulmonary Clinic
RECRUITING

Chicago, Illinois, 60612, United States
SLK Kliniken Heilbronn GmbH
RECRUITING

Löwenstein, 74245, Germany
Saint Luke's Hospital of Kansas City
RECRUITING

Kansas City, Missouri, 64111, United States
Sanatorio Allende Cerro
RECRUITING

Córdoba, 5021, Argentina
Sanatorio Parque de Rosario - Consultorios Externos
RECRUITING

Rosario, Santa Fe Province, 2000, Argentina
Seoul National University Bundang Hospital
RECRUITING

Seongnam-si, 13620, South Korea
Shaare Zedek Medical Center
RECRUITING

Jerusalem, 9103102, Israel
St George Hospital
RECRUITING

Kogarah, New South Wales, 2217, Australia
St. Luke's Univeristy Health Network-Pulmonary & Critical Care
RECRUITING

Cincinnati, Ohio, 45227, United States
St.Joseph's Healthcare Hamilton
RECRUITING

Hamilton, Ontario, L8N 4A6, Canada
St.Paul's Hospital
RECRUITING

Vancouver, British Columbia, V6Z 176, Canada
Stanford University Medical Center
RECRUITING

Stanford, California, 94305, United States
StatCare Pulmonary Consultants, PLLC
RECRUITING

Knoxville, Tennessee, 37919, United States
Stony Brook Advanced Specialty Care
RECRUITING

Stony Brook, New York, 11794-8172, United States
TGH/USF Center for Advanced Lung Disease and Lung Transplant
RECRUITING

Tampa, Florida, 33606, United States
Taichung Veterans General Hospital
RECRUITING

Taichung, 40705, Taiwan
Tel Aviv Sourasky Medical Center
RECRUITING

Tel Aviv, 6423906, Israel
Temple University Hospital
RECRUITING

Philadelphia, Pennsylvania, 19140, United States
The Catholic University of Korea, Eunpyeong St. Mary's Hospital
RECRUITING

Seoul, 3312, South Korea
The Emory Clinic
RECRUITING

Atlanta, Georgia, 45227, United States
The Hadassah University Medical Center Ein Kerem Hospital
RECRUITING

Jerusalem, 9112001, Israel
The Lung Research Center, LLC
RECRUITING

Chesterfield, Missouri, 63017, United States
The Ohio State University Wexner Medical CEnter
RECRUITING

Columbus, Ohio, 43201, United States
The Prince Charles Hospital
RECRUITING

Brisbane, Queensland, Australia, Australia
The University of Texas Health Science Center at Houston, McGovern Medical School
RECRUITING

Houston, Texas, 77030, United States
The Vanderbilt Lung Institute
RECRUITING

Nashville, Tennessee, 37204, United States
Tufts Medical Center
RECRUITING

Boston, Massachusetts, 02111, United States
Tulane Medical Center
RECRUITING

New Orleans, Louisiana, 45227, United States
UAB Lung Health Center
RECRUITING

Birmingham, Alabama, 35233, United States
UC Davis Health Medical Center
RECRUITING

Sacramento, California, 95817, United States
UI Health Hospital
RECRUITING

Chicago, Illinois, 60612, United States
UT Southwestern Medical Center-Advanced Lung Clinic
RECRUITING

Dallas, Texas, 75390, United States
UZ Leuven
RECRUITING

Leuven, 3000, Belgium
Unidad de Investigacion de Enfermedades Respiratorias- Clinica San Pablo -Surco
RECRUITING

Lima, 15023, Peru
Universitair Ziekenhuis Gent
RECRUITING

Ghent, 9000, Belgium
University Hospital and UW Health Clinics
RECRUITING

Madison, Wisconsin, 53792, United States
University of California Irvine Medical Center
RECRUITING

Orange, California, 92868, United States
University of Cincinnati Medical Center
RECRUITING

Cincinnati, Ohio, 45219, United States
University of Kansas Medical Center
RECRUITING

Kansas City, Kansas, 66160, United States
University of Kentucky
RECRUITING

Lexington, Kentucky, 45227, United States
University of Louisville Healthcare Outpatient Research Clinic
RECRUITING

Louisville, Kentucky, 40202, United States
University of Maryland Medical Center
RECRUITING

Baltimore, Maryland, 45227, United States
University of Minnesota Health Clinical Research Unit (CRU)
RECRUITING

Minneapolis, Minnesota, 55455, United States
University of New Mexico
RECRUITING

Albuquerque, New Mexico, 87131, United States
University of Utah Health
RECRUITING

Salt Lake City, Utah, 84108, United States
University of Virginia Health System
RECRUITING

Charlottesville, Virginia, 22903, United States
Waikato Hospital
RECRUITING

Hamilton, 3204, New Zealand
Wake Forest Baptist Health
RECRUITING

Winston-Salem, North Carolina, 27104, United States
Washington University School of Medicine
RECRUITING

St Louis, Missouri, 63110, United States
Weill Cornell Medicine, New York-Presbyterian Hospital
RECRUITING

New York, New York, 10065, United States
ZAS Middelheim
RECRUITING

Antwerp, 2020, Belgium
Zentralklinik Bad Berka GmbH Klinik für Pneumologie, Zentrum für Schlaf-und Beatmungsmedizin
RECRUITING

Bad Berka, 99437, Germany
uhrlandklinik Westdeutsches Lungenzentrum am Universitätsklinikum Essen gGmbH
RECRUITING

Essen, 45239, Germany

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