Can antidepressants stop a debilitating cough? new trial aims to find out

NCT ID NCT05120934

Recruiting now Symptom relief Sponsor: Mayo Clinic Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether two drugs, duloxetine and amitriptyline, can reduce chronic coughing in people with interstitial lung disease (ILD). 25 participants will receive either a low or high dose of one drug or a placebo for 4 weeks. The main goal is to see if cough frequency decreases, measured by a special cough monitor.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: duloxetine and amitriptyline
What this could lead to: If successful, this could point toward a new treatment option to ease chronic coughing in people with interstitial lung disease.
What could go wrong: This is a small, early-phase pilot study with only 25 participants. It may not show a clear benefit, and the drugs can cause side effects like drowsiness or dry mouth.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Chronic Cough Cough Fibrosis interstitial lung disease pulmonary fibrosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

INTERSTITIAL LUNG DISEASE

Contacts and locations

Locations

Mayo Clinic in Rochester
RECRUITING

Rochester, Minnesota, 55905, United States

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