Old antibiotic, new hope: doxycycline may shield TB patients from lasting lung harm
NCT ID NCT05473520
First seen Nov 01, 2025 · Last updated Jun 23, 2026 · Updated 37 times
Summary
This Phase 3 trial tests whether adding doxycycline to standard tuberculosis treatment can reduce permanent lung damage and lower the risk of heart problems. Researchers will give 150 adults either doxycycline or a placebo for 8 weeks alongside their TB medication. The main goal is to see if lung function improves at 6 months, with follow-up for up to 2 years.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Hospital Queen Elizabeth I
NOT_YET_RECRUITINGKota Kinabalu, Sabah, Malaysia
Contact
Contact Email: •••••@•••••
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Klinik Kesihatan Luyang
ACTIVE_NOT_RECRUITINGKota Kinabalu, Sabah, Malaysia
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Klinik Kesihatan Menggatal
RECRUITINGKota Kinabalu, Sabah, Malaysia
Contact Phone: •••-•••-••••
Contact Phone: •••-•••-••••
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National University Hospital
RECRUITINGSingapore, Singapore, 119228, Singapore
Contact Email: •••••@•••••
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TB Control Unit
RECRUITINGSingapore, Singapore
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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Universiti Malaysia Sabah (UMS), Borneo Medical and Health Research Centre
ACTIVE_NOT_RECRUITINGKota Kinabalu, Sabah, Malaysia
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
doxycycline
What this could lead to
If it works, this could point toward a way to prevent permanent lung damage and heart problems after tuberculosis treatment.
What could go wrong
This is a mid-stage trial with only 150 participants, so results may not apply to everyone. Doxycycline can cause side effects like sun sensitivity and stomach upset.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.