Old antibiotic, new hope: doxycycline may shield TB patients from lasting lung harm

NCT ID NCT05473520

Recruiting now Disease control Sponsor: National University Hospital, Singapore Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This Phase 3 trial tests whether adding doxycycline to standard tuberculosis treatment can reduce permanent lung damage and lower the risk of heart problems. Researchers will give 150 adults either doxycycline or a placebo for 8 weeks alongside their TB medication. The main goal is to see if lung function improves at 6 months, with follow-up for up to 2 years.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: doxycycline
What this could lead to: If it works, this could point toward a way to prevent permanent lung damage and heart problems after tuberculosis treatment.
What could go wrong: This is a mid-stage trial with only 150 participants, so results may not apply to everyone. Doxycycline can cause side effects like sun sensitivity and stomach upset.

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Conditions

The condition(s) this trial relates to.

acute coronary syndrome disease pulmonary hypertension pulmonary tuberculosis tuberculosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ACUTE CORONARY SYNDROME PULMONARY HYPERTENSION (DIAGNOSIS) TUBERCULOSIS

Contacts and locations

Locations

Hospital Queen Elizabeth I
NOT_YET_RECRUITING

Kota Kinabalu, Sabah, Malaysia
Klinik Kesihatan Luyang
ACTIVE_NOT_RECRUITING

Kota Kinabalu, Sabah, Malaysia
Klinik Kesihatan Menggatal
RECRUITING

Kota Kinabalu, Sabah, Malaysia
National University Hospital
RECRUITING

Singapore, Singapore, 119228, Singapore
TB Control Unit
RECRUITING

Singapore, Singapore
Universiti Malaysia Sabah (UMS), Borneo Medical and Health Research Centre
ACTIVE_NOT_RECRUITING

Kota Kinabalu, Sabah, Malaysia

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