Xenon MRI breathes new life into lung disease detection

NCT ID NCT04991454

Recruiting now Diagnosis Sponsor: Bastiaan Driehuys Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 11, 2026 · Updated 2 times

Summary

This study explored whether a special type of MRI using inhaled xenon gas could detect changes in the small blood vessels of the lungs in people with pulmonary hypertension. The goal was to see if this imaging method could track disease progression or response to treatment. However, the trial was terminated early and only enrolled 12 participants, so the findings are limited.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Hyperpolarized xenon gas
What this could lead to: If successful, this could provide a new, non-invasive way to monitor lung blood vessel health in pulmonary hypertension patients.
What could go wrong: The trial was terminated early and enrolled only 12 people, so results are very limited. It is unclear if the technique will be reliable or useful in practice.

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Conditions

The condition(s) this trial relates to.

chronic thromboembolic pulmonary hypertension pulmonary arterial hypertension pulmonary hypertension pulmonary hypertension owing to lung disease and/or hypoxia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PULMONARY ARTERIAL HYPERTENSION PULMONARY HYPERTENSION

Contacts and locations

Locations

Duke University Medical Center
RECRUITING

Durham, North Carolina, 27710, United States

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