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Could a common heart drug save babies with a rare birth defect?

NCT ID NCT02951130

Completed Disease control Sponsor: NICHD Neonatal Research Network Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at whether a medicine called milrinone can improve oxygen levels in newborns with congenital diaphragmatic hernia (CDH), a birth defect that causes severe breathing problems. The trial included 66 babies who were on breathing machines. The goal was to see if milrinone, which helps the heart pump and relaxes blood vessels in the lungs, could help when standard treatments fail. This was a small, early-phase study to check safety and effectiveness.

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Conditions

The condition(s) this trial relates to.

congenital diaphragmatic hernia persistent fetal circulation syndrome pulmonary hypoplasia respiratory failure

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CONGENITAL DIAPHRAGMATIC HERNIA HYPOXEMIC RESPIRATORY FAILURE PERSISTENT PULMONARY HYPERTENSION OF THE NEWBORN PULMONARY HYPOPLASIA

Contacts and locations

Locations

  • Brown University, Women & Infants Hospital of Rhode Island

    Providence, Rhode Island, 02905, United States

  • Case Western Reserve University, Rainbow Babies and Children's Hospital

    Cleveland, Ohio, 44106, United States

  • Children's Hospital of Wisconsin

    Milwaukee, Wisconsin, 53226, United States

  • Children's Mercy

    Kansas City, Missouri, 64108, United States

  • Cincinnati Children's Medical Center

    Cincinnati, Ohio, 45267, United States

  • Columbia University

    New York, New York, 10032, United States

  • Duke University

    Durham, North Carolina, 27710, United States

  • Emory University

    Atlanta, Georgia, 30303, United States

  • RTI International

    Durham, North Carolina, 27709, United States

  • Research Institute at Nationwide Children's Hospital

    Columbus, Ohio, 43205, United States

  • Stanford University

    Palo Alto, California, 94304, United States

  • University of Alabama at Birmingham

    Birmingham, Alabama, 35233, United States

  • University of Iowa

    Iowa City, Iowa, 52242, United States

  • University of New Mexico

    Albuquerque, New Mexico, 87131, United States

  • University of Pennsylvania

    Philadelphia, Pennsylvania, 19104, United States

  • University of Rochester

    Rochester, New York, 14642, United States

  • University of Texas Health Science Center at Houston

    Houston, Texas, 77030, United States

  • University of Texas Southwestern Medical Center at Dallas

    Dallas, Texas, 75235, United States

  • University of Utah

    Salt Lake City, Utah, 84108, United States

More trials for these conditions

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