Immunotherapy-Chemo cocktail aims to shrink head and neck tumors before treatment
NCT ID NCT05758389
First seen Jun 26, 2026 · Last updated Jun 26, 2026
Summary
This study tests whether combining the immunotherapy drug tislelizumab with chemotherapy (paclitaxel, cisplatin, 5-FU) can shrink advanced head and neck tumors before surgery or chemoradiation. About 29 adults with stage III-IVb cancer will receive the combo for three cycles. Researchers will check tumor size and look for complete remission, while monitoring side effects.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- tislelizumab (PD-1 inhibitor) combined with paclitaxel, cisplatin, and 5-FU chemotherapy
- What this could lead to
- If successful, this could offer a new treatment option for locally advanced head and neck cancer, potentially improving tumor shrinkage before surgery or chemoradiation.
- What could go wrong
- This is a small, early-phase trial with only 29 participants and no comparison group, so results may not apply broadly. Side effects from immunotherapy and chemotherapy can be serious.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Department of Oncology, Drum Tower Hospital, Nanjing University School of Medicine
RECRUITINGNanjing, Jiangsu, China
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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- New cocktail aims to shrink head and neck tumors before surgery