Could skipping some neck radiation spare patients side effects?
NCT ID NCT07755449
First seen Aug 10, 2026 · Last updated Aug 11, 2026 · Updated 1 time
Summary
This trial is testing whether it is safe to skip radiation to certain low-risk areas of the neck after surgery for head and neck cancer. The goal is to see if this approach can reduce side effects and preserve quality of life while still keeping the cancer from coming back. Participants will receive standard radiation to the main tumor area, but not to the neck regions that were surgically cleared of cancer. The study will compare their outcomes to historical data from patients who received full neck radiation.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Radiotherapy (IMRT or VMAT) that selectively omits radiation to low-risk neck areas, with optional concurrent cisplatin chemotherapy
- What this could lead to
- If successful, this approach could reduce side effects and improve quality of life for head and neck cancer patients after surgery, without increasing the risk of cancer returning.
- What could go wrong
- This is a phase II trial with a modest number of patients, and the strategy may not be as effective as standard radiation in preventing cancer recurrence. There is also a risk of increased recurrence in the omitted areas.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Institut Català d'Oncologia
RECRUITINGL'Hospitalet de Llobregat, Barcelona, 08908, Spain
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