Diabetes and fatigue: can special exercise training help?

NCT ID NCT04442451

Recruiting now Knowledge-focused Sponsor: University of Michigan Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looks at why people with pre-diabetes or type 2 diabetes tire more quickly during leg exercises. Researchers will test a special low-load resistance training program, sometimes with blood flow restriction, to see if it improves muscle strength, blood flow, and energy use. The goal is to understand the underlying causes of fatigue and design better exercise plans for people with diabetes.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: low-load knee extension resistance training with and without blood flow restriction
What this could lead to: If successful, this research could lead to more effective, targeted exercise programs for people with diabetes to improve muscle function and reduce fatigue.
What could go wrong: This is an early-stage observational and interventional study with only 80 participants. The findings may not apply to all people with diabetes, and the exercise protocols may be too demanding for some.

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Conditions

The condition(s) this trial relates to.

diabetes mellitus glucose intolerance prediabetes syndrome type 2 diabetes mellitus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PRE-DIABETES TYPE 2 DIABETES

Contacts and locations

Locations

University of Michigan
RECRUITING

Ann Arbor, Michigan, 48109, United States

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