Sound waves aimed at liver and nerves could tame diabetes

NCT ID NCT05354947

Recruiting now Disease control Sponsor: Yale University Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This early study tests whether delivering focused ultrasound pulses to the liver and a nearby nerve bundle can improve blood sugar control in people with type 2 diabetes. Thirty adults on stable oral diabetes medications will receive the ultrasound treatment. The main goal is to check for side effects like liver enzyme changes, but researchers will also monitor blood sugar levels to see if the approach shows promise.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: focused pulsed ultrasound delivered via a GE LOGIQ E10 machine
What this could lead to: If it works, this could point toward a non-drug, non-invasive way to help manage blood sugar in type 2 diabetes.
What could go wrong: This is a very early, small pilot study (30 people) focused on safety, not effectiveness. It may not show any meaningful blood sugar improvement, and there is a risk of liver enzyme elevation or low blood sugar.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

type 2 diabetes mellitus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

TYPE 2 DIABETES

Contacts and locations

Locations

Yale-New Haven Hospital
RECRUITING

New Haven, Connecticut, 06510, United States

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