TYPE 2 DIABETES

This study tested whether the injectable medication tirzepatide helps control blood sugar and promotes weight loss in Chinese adults with type 2 diabetes. 206 participants were randomly assigned to receive either tirzepatide or a placebo injection for several months. Researchers …

This study looked back at whether a new way of explaining diabetes during clinic visits could help people manage their blood sugar better. It tested a method called M2-PRIME, which uses simple analogies like comparing insulin to a garbage truck, to help patients understand their …

This early-stage study tested a new drug called AZD5004 to see if it was safe for people to take. It involved 45 Chinese adults who were overweight or had obesity, some of whom also had type 2 diabetes. The main goal was to check for side effects and see how the drug moved throug…

This study tested whether a diet low in 'advanced glycation end products' (AGEs)—harmful compounds formed when food is cooked at high temperatures—could improve health markers in people with type 2 diabetes and coronary artery disease. Thirty-six participants followed a low-AGE d…

This study tested a new magnetic device designed to perform a type of weight-loss surgery. The device connects part of the small intestine to the stomach to help manage weight and improve blood sugar levels in adults with obesity and type 2 diabetes. The main goal was to see if t…

This study aimed to understand and reduce long periods of sitting in Black older adults with type 2 diabetes. Researchers worked with 33 participants to learn about their daily habits and co-design strategies to break up sedentary time. The goal was to see if reducing sitting cou…

This study tested whether providing free, diabetes-friendly meals and nutrition education for six months could help low-income adults with type 2 diabetes better manage their condition. Researchers enrolled 281 participants who were struggling with food insecurity and randomly as…

This study tested whether regular phone sessions with a nurse educator could help low-income seniors better manage their type 2 diabetes. Researchers compared two groups of 100 participants each - one received diabetes education and behavioral coaching, while the other received g…

This early-stage study tested the safety of a new oral medication called LY3549492 for type 2 diabetes in Chinese adults. Thirty-six participants took daily doses of either the drug or a placebo for about 18 weeks. The main goal was to check for side effects and see how the drug …

This early-stage study tested a new, long-acting injection called NEX-22A in 12 people with type 2 diabetes. The main goal was to see how the drug moves through the body and to check for any side effects. Participants received a single injection, and researchers monitored them cl…

This large, late-stage study tested a once-daily oral medication called LY3502970 (orforglipron) to see if it could help people lose weight and better manage their type 2 diabetes. Over 1,600 adults with obesity or overweight and type 2 diabetes participated, comparing the drug t…

This study tested whether a new insulin injection called THDB0206 works as well as a standard insulin combination for controlling blood sugar in people with type 2 diabetes. It involved over 1,000 Chinese adults who were already using insulin. The main goal was to see if the new …

This study tested whether regular follow-up visits with nurses and dietitians help people with type 2 diabetes manage their condition better. 398 patients received education on diet and exercise, then were split into two groups: one received check-ups every three months, and the …

This study tested if a phone-based program using text messages and small financial rewards could help teens and young adults with prediabetes or type 2 diabetes become more physically active. It involved 75 participants aged 13 to 22. The goal was to see if this approach could in…

This study tested if adding a nurse practitioner trained in diabetes care to a cancer treatment team could help patients better manage their diabetes while undergoing breast cancer treatment. It involved 74 adults with breast cancer and either prediabetes or type 2 diabetes. The …

This study tested a new diabetes education and nutrition program designed specifically for adults with physical disabilities and Type 2 diabetes. Researchers compared different support methods, including weekly coaching calls and technology access, to see which worked best. The g…

This study tested a once-daily oral medication called orforglipron for adults with type 2 diabetes whose blood sugar was not well controlled on insulin. It aimed to see if the pill could lower blood sugar and body weight more effectively than a placebo over about 46 weeks. The tr…

This study analyzed health records of over 380,000 adults with type 2 diabetes to compare four common second-line medications. Researchers wanted to see which drug class—GLP-1RAs, SGLT2is, DPP-4is, or sulfonylureas—was most effective at preventing major heart problems like heart …

This study tested whether an investigational drug called retatrutide could improve kidney function in people who are overweight or obese and have chronic kidney disease, with or without type 2 diabetes. The 31-week trial involved 146 participants and compared the drug's effects t…

This study tested a new diabetes medication called Teneligliptin (MP-513) to see if it safely lowers blood sugar levels in Japanese adults with type 2 diabetes. Over 300 participants took either the drug or a placebo pill daily for 12 weeks. The main goal was to measure changes i…

This study tested whether a new digital system could help hospital staff better manage blood sugar in patients with type 2 diabetes. The system used continuous glucose monitors that wirelessly sent data to a dashboard, allowing staff to remotely monitor many patients at once and …

This large study compared four common diabetes medications when added to metformin to see which combination best controls blood sugar over time. Researchers followed nearly 8,000 people with type 2 diabetes for several years, tracking how long each medication kept blood sugar lev…

This study tested the safety and feasibility of a new endoscopic procedure called DyaMX for people with type 2 diabetes. The procedure aims to regenerate the lining of the small intestine to help improve blood sugar control. 65 adults whose diabetes wasn't well-controlled on curr…

This study investigated whether the diabetes medication canagliflozin could reduce harmful scarring in the heart muscle of people with type 2 diabetes who are at high risk for heart disease. Researchers used special heart scans to measure scarring in 45 participants before and af…

This study tested a new daily pill called LY3502970 against an existing medication, oral semaglutide, in adults with type 2 diabetes whose blood sugar wasn't well controlled on metformin alone. It involved 1,698 participants and lasted about 61 weeks. The main goal was to see whi…

This study tested a one-year program to help older adults better manage their type 2 diabetes from home. Over 500 participants received phone calls from nurses to set personal health goals and were connected to local community resources. The goal was to improve daily life and red…

This study tested whether a 12-week online mindfulness program was practical and acceptable for teenagers with prediabetes or type 2 diabetes. Researchers enrolled 30 teens to learn mindfulness skills like breath awareness and mindful eating in virtual group sessions. The main go…

This study tested whether replacing sitting time with standing and light walking could improve daily blood sugar control. It involved 18 South Asian adults with overweight or obesity who normally sat a lot. Participants tried two different 4-day routines: one with lots of sitting…

This study tested a new once-daily pill called orforglipron against an existing drug, dapagliflozin, in adults with type 2 diabetes whose blood sugar was still too high on metformin. The main goal was to see which drug was better and safer at lowering blood sugar over about 46 we…

This study tested whether an experimental drug called MCI-196 could help control type 2 diabetes. For 12 weeks, 183 adults with elevated blood sugar took either the drug or a placebo pill, and neither they nor their doctors knew which one. Researchers measured changes in blood su…

This study tested whether adding a mangosteen fruit supplement to standard diabetes medication (sitagliptin/metformin) improved health outcomes for adults newly diagnosed with type 2 diabetes. Over 12 weeks, researchers compared two groups—one taking just the medication and one t…

This study tested two different ways to help people with type 2 diabetes start using a continuous glucose monitor (CGM). It compared a nutrition-focused coaching approach against a self-guided approach to see which one helped people spend more time with their blood sugar in a hea…

This study tested a new weekly injection called CagriSema for people with type 2 diabetes who were already taking daily insulin. The goal was to see if adding CagriSema could help lower blood sugar levels and reduce body weight more effectively than a placebo injection. About 274…

This study investigated whether taking magnesium oxide supplements could help people with type 2 diabetes better manage their condition. Researchers gave magnesium or a placebo (dummy pill) to 247 adults with diabetes for a full year to see if it improved key health markers like …

This study tested whether an 8-week personalized exercise program could improve heart and blood vessel function in men with type 2 diabetes or obesity. Researchers compared these men to healthy volunteers to understand how these conditions affect the body during rest and exercise…

This study tested whether two different intermittent fasting approaches could help people with type 2 diabetes better control their blood sugar levels. Researchers worked with 57 adults recently diagnosed with diabetes to see if following specific eating schedules for one year wa…

This small pilot study tested two different health coaching strategies for Black adults with obesity and related conditions like high blood pressure or prediabetes. One approach focused on weight loss, while the other focused on increasing physical activity without emphasizing we…

This study tested whether a new weekly injection called CagriSema could slow kidney damage in adults with type 2 diabetes, chronic kidney disease, and overweight or obesity. It compared CagriSema against its individual components (semaglutide and cagrilintide) and a placebo over …

This study tested whether a virtual weight management program, combined with a continuous glucose monitor, could help adults with type 2 diabetes better control their blood sugar. 152 participants were assigned to either try this digital program or continue with their usual care …

This study compared three popular healthy diets—Mediterranean, DASH, and MIND—to see which one best helps people with type 2 diabetes manage their condition. Researchers measured blood sugar, cholesterol, weight, and body fat in 90 adults with diabetes to see how well they follow…

This study tested whether a new version of a diabetes medication gets into the bloodstream the same way as an existing brand-name version. It involved 36 healthy adults who each took both versions of the drug. Researchers measured drug levels in the blood to see if the two versio…

This was the first study in humans to test the safety and basic effects of an experimental drug called CT-996. It involved 94 overweight or obese adults, some with type 2 diabetes, to see how their bodies handled the drug and if it caused any side effects. The main goal was to de…

This small, completed study tested a new magnetic device for creating a partial intestinal bypass. The goal was to see if this new surgical method was safe and could help adults with obesity and type 2 diabetes manage their weight and blood sugar. The procedure reroutes food thro…

This study tested whether a simple, easy-to-follow program focused on eating a very low-carbohydrate breakfast could help adults with poorly controlled type 2 diabetes. Researchers enrolled 119 participants to try the 4-month online program, measuring if it was acceptable and if …

This small, completed study tested if a new method for adjusting daily insulin doses works better than the standard method. It compared using data from a continuous glucose monitor (CGM) sensor to using traditional fingerstick checks. The goal was to see if the CGM method helped …

This study tested whether a diabetes education program, originally designed for homes, would work well when offered in group sessions at churches. It involved 321 adult Marshallese people with type 2 diabetes, who each brought a family member to learn together. The main goal was …

This small, completed study tested whether gummy candies made from maqui berry could help control blood sugar and antioxidant levels in overweight adults. Ten participants ate white bread alone, bread with regular gummies, and bread with a special encapsulated gummy version on se…

This study tested whether using a mobile app called Undermyfork along with a continuous glucose monitor (CGM) helps people manage type 2 diabetes better than standard care. It involved 91 adults with type 2 diabetes who were not using insulin. The goal was to see if real-time glu…

This study tested a new connected insulin pen system to see if it helps people with type 1 or type 2 diabetes remember to take their insulin doses on time. Researchers measured how often doses were missed and tracked blood sugar control in about 36 participants. The goal was to s…

This study compared two different eating approaches to see which works better for managing type 2 diabetes. 182 participants with diabetes followed either a very low-carbohydrate diet or a plate-method diet for one year. Researchers measured how each diet affected blood sugar con…

This study followed 110 adults with obesity or overweight plus liver disease to see how well they could stick to different versions of a very-low-calorie ketogenic diet in regular medical care. Participants chose from four diet plans that varied in how much they used natural food…

This small pilot study tested a behavioral program to help adults with type 2 diabetes. Participants used a continuous glucose monitor, and some also received coaching and financial rewards for meeting blood sugar goals. The goal was to see if this combination could improve how w…

This large study looked back at health records of over 450,000 adults with type 2 diabetes and obesity to see if starting two newer types of diabetes drugs (GLP-1s and SGLT2is) close together is better than other strategies. It aimed to find out which early drug combination leads…

This completed Phase 3 trial tested a new weekly injection called CagriSema in adults with type 2 diabetes whose blood sugar wasn't well controlled by diet and exercise alone. The study compared two doses of CagriSema against a placebo (dummy medicine) in 189 participants over ab…

This study tested whether an automated insulin delivery system could better control blood sugar in hospitalized adults with type 1 or type 2 diabetes compared to standard insulin injections. 130 participants were randomly assigned to use either the automated system or receive sta…

This large, completed study directly compared two common type 2 diabetes medications—dapagliflozin and metformin—to see which one is better at preventing serious long-term health problems. Over 2,000 adults with early-stage diabetes were randomly assigned to take one of the drugs…

This study tested whether a combination of Clinical Pilates exercises, nurse coaching, and peer group meetings could improve overall health for older adults living with type 2 diabetes. Forty-eight participants aged 65 and older were split into different groups to receive one or …

This study tested whether a 6-week mindfulness training program could help overweight teenagers who are at risk for developing type 2 diabetes. Researchers compared mindfulness training against two other approaches—cognitive behavioral therapy and health education—to see which wa…

This small pilot study tested whether a mobile phone app could help adults who have binge eating, type 2 diabetes, and difficulty affording food. The goal was to see if the app was practical and acceptable for helping people manage their eating behaviors and weight. Researchers m…

This study tested whether a new once-weekly medicine called IcoSema works as well as daily insulin injections for controlling blood sugar in people with type 2 diabetes. 485 adults whose diabetes wasn't well-controlled with pills participated in this 11-month trial. Researchers r…

This study tested whether a new oral medication called HRS-7535 could help adults with type 2 diabetes who still had high blood sugar despite taking two common diabetes drugs (metformin and an SGLT2 inhibitor). For 16 weeks, 155 participants received either the new drug or a plac…

This study tested whether a program of simple, equipment-free exercises (calisthenics) delivered through video calls (telerehabilitation) could help people with type 2 diabetes. Researchers worked with 40 adults to see if this home-based exercise routine could improve their body'…

This small pilot study tested if using an automated insulin pump for just 10 days could safely and quickly help find the right daily insulin dose for adults with type 2 diabetes. Researchers compared blood sugar control in 23 participants who either used the pump or followed stan…

This study tested a new insulin patch pump system to see if it works as well as a standard insulin pump for controlling blood sugar. 161 adults with type 1 or type 2 diabetes were randomly assigned to use either the new patch pump or a standard pump for one week in a hospital set…

This study tested whether a digital health program on tablets could help community health workers better screen and manage health risks for pregnant women in rural India. Over 3,400 women participated to see if the program could reduce anemia and improve follow-up care for high b…

This study tested if taking a sodium butyrate supplement for 12 weeks, along with a reduced-calorie diet, helps people lose more weight than a diet alone. It involved 46 overweight or obese adults, some with type 2 diabetes, to see if the supplement also improved blood sugar, cho…

This study aimed to find out if a computer program could detect Type 2 diabetes by analyzing a person's voice. Over 7,300 adults in the UK recorded their voice and answered health questions online. The goal was to see if this voice analysis could be as useful as a standard blood …

This study tested whether making three national healthy diet patterns more culturally relevant could help African American adults eat better and lower their risk for type 2 diabetes. Researchers worked with 63 participants who were overweight and had multiple diabetes risk factor…

This study tested a 3-month mobile web program called STEPS, designed to help Hispanic adults living in rural areas lower their risk of developing type 2 diabetes. 179 participants at high risk for diabetes were randomly assigned to either use the STEPS app or receive their usual…

This study tested if adding mindfulness techniques to diabetes education could help people who find managing their condition very stressful. It compared a new mindfulness-based program to standard diabetes self-management classes for adults with type 2 diabetes and high levels of…

This study tested whether a specific set of leg exercises, called Buerger-Allen exercises, can improve blood flow in the feet and legs of people with type 2 diabetes. Poor circulation is a common problem that can lead to serious complications. Researchers compared 74 participants…

This study tested a phone-based coaching program designed to help veterans with type 2 diabetes. The goal was to reduce the emotional burden and stress of managing the disease daily. First, researchers asked some veterans to take photos to help explain their challenges. Then, a s…

This study tested whether a special board game could help adults with type 2 diabetes who are starting insulin. Researchers wanted to see if playing the game in group sessions would lower anxiety about treatment and help people stick to their care plan better than a standard lect…

This study looked at whether a newer type of diabetes medicine (SGLT2 inhibitors) might lower the risk of developing lung cancer compared to an older type (sulfonylureas) in people who have both type 2 diabetes and COPD. Researchers analyzed the existing medical records of over 2…

This study aimed to better understand the links between gum disease, type 2 diabetes, and diabetic kidney disease by measuring specific inflammation markers. Researchers compared 126 people with either newly diagnosed diabetes or diabetes with kidney problems, grouping them by th…

This study aimed to see if people with type 2 diabetes living in France could follow a Mediterranean diet for a year. Researchers enrolled 60 patients to learn about their eating habits, teach them the diet, and then check in at 3 and 12 months. The main goal was to see how many …

This study aimed to find out if chemicals in a person's breath change when their blood sugar levels go up or down. Researchers tested 20 people with Type 2 diabetes, measuring their breath with special devices while their blood sugar was changed on purpose. The goal was to gather…

This study aimed to test how reliable and repeatable a special type of MRI scan is for measuring body composition and the health of several organs. It involved 43 adults, including people with Type 2 diabetes and healthy volunteers, who underwent MRI scans. The main goal was to s…

This study aimed to understand if the brain's master clock, which controls daily rhythms, is disrupted in people with insulin resistance and type 2 diabetes. Researchers used a powerful brain scanner to measure the clock's activity in 28 obese adults with varying levels of insuli…

This study aimed to predict the results of a major heart drug trial before it finishes. Researchers analyzed health insurance records from over 44,000 people with type 2 diabetes and heart disease to see if one diabetes drug (tirzepatide) is better than another (dulaglutide) at p…

This small study aimed to understand how the type of food eaten before exercise affects blood sugar levels in men with type 2 diabetes. Fifteen participants ate different test meals (high in glucose, fructose, fat, or a sugar substitute) and then performed a one-hour cycling sess…

This study investigated whether drinking a type of high-quality 'specialty coffee' could improve memory and thinking speed in people with type 2 diabetes, who have a higher risk of cognitive decline. Forty participants who were already coffee drinkers tested a specialty coffee an…

This study aimed to find out if drinking diet sodas or water is better for people managing type 2 diabetes. Researchers followed 181 adults with diabetes for 24 weeks, having one group drink three servings of diet soda daily and another drink three servings of water. They measure…

This study aimed to understand why some people respond better than others to certain diabetes medications. Researchers followed 260 obese adults with newly diagnosed Type 2 diabetes for six months, giving them either empagliflozin, dapagliflozin, or standard care. The main goal w…

This early-stage study tested how the body absorbs and processes a new combination pill for type 2 diabetes, called CKD-383, compared to taking its three separate drug components. The study involved 30 healthy adult volunteers who took each treatment once, with a week break in be…

This study aimed to understand if a person's psychological profile is linked to developing foot wounds in type 2 diabetes. Researchers compared 66 people with diabetes and foot wounds to people with diabetes but no wounds. They used a personality questionnaire to see if certain t…

This study analyzed health insurance records of nearly 900,000 people to compare how well different diabetes and weight management drugs protect against serious heart problems. It specifically looked at tirzepatide (Mounjaro/Zepbound) and semaglutide (Ozempic/Wegovy) versus other…

This was the first study to give a new drug called NNC0113-6856 to people. The main goal was to check its safety and see how the body absorbs and processes it. The study involved 70 healthy male volunteers who received either a single oral dose or an injection. Researchers measur…

This study aimed to understand if being diagnosed with gestational diabetes earlier in pregnancy (before 24 weeks) leads to a higher risk of having diabetes or blood sugar problems after giving birth, compared to being diagnosed later. Researchers followed 500 pregnant women with…

This study aimed to see if data from a wrist-worn smartwatch, combined with medical records, could be used by artificial intelligence to find digital signs of type 2 diabetes. It involved 210 adults, some with diabetes and some without, who wore a special watch during two observa…

This study aimed to understand why some patients with type 2 diabetes experience an increase in 'bad' cholesterol when taking the medication dapagliflozin. It involved 28 participants who were randomly assigned to take either the drug or a placebo for six months. Researchers trac…

This early-stage study aimed to understand how the body processes and tolerates a new combination pill for type 2 diabetes, called CKD-383. Researchers compared it to taking its three separate drug components together. The study involved 31 healthy adult volunteers to measure dru…

This small, completed study aimed to better understand how brown fat, a type of 'good' body fat that burns calories for heat, works in people with type 2 diabetes. Researchers used cold exposure and advanced medical scans on a small group of people with and without diabetes to me…

This early-stage study aimed to understand how the body processes a new combination diabetes medication (CKD-383) compared to taking its three separate components together. The study involved 30 healthy adult volunteers who received both treatments in a specific order with a brea…

This small study aimed to understand if a specific brain chemical pathway contributes to high blood pressure in people with type 2 diabetes. Researchers tested if a drug called aprepitant (normally used for nausea) could change levels of key hormones like aldosterone in five diab…