TYPE 2 DIABETES

This early-stage trial tested a new vaccine against Group B Streptococcus (GBS) in 90 healthy adults aged 55 to 75. Participants received three doses of the vaccine or a placebo, and researchers monitored safety and immune response for six months. The goal is to see if the vaccin…

This study tests the long-term safety of an experimental oral drug called orforglipron in adults with type 2 diabetes whose blood sugar is not well controlled by diet, exercise, or other diabetes pills. Participants take the drug once daily for about a year, and researchers monit…

This study compares a new drug, HRS-7535, to an existing diabetes medication, dapagliflozin, in adults with type 2 diabetes whose blood sugar is not well controlled with metformin alone. The goal is to see if HRS-7535 works better at lowering blood sugar and body weight over 32 w…

This trial investigates whether changing how often and when people with type 2 diabetes eat can improve weight, blood sugar, and cholesterol. Over 12 weeks, participants follow one of three eating plans: a standard 6-meal diet, a 3-meal diet, or time-restricted eating (eating all…

This study tested a family-focused diabetes education program delivered in Marshallese faith-based organizations. Over 300 adults with type 2 diabetes and their family members took part. The goal was to see if group education in a familiar community setting could improve blood su…

This study tested an electronic glucose management system (eGMS) designed to help doctors decide insulin doses for hospitalized patients with type 2 diabetes. The trial compared the eGMS to the usual insulin ordering protocol in 140 patients. The goal was to see if the eGMS could…

This completed trial tested whether laser acupuncture could improve body shape index (ABSI) in 50 women aged 40-50 with uncontrolled type 2 diabetes and obesity. Participants received either real or sham laser acupuncture twice a week for 12 weeks, plus a low-glycemic diet. The s…

This study tested whether personalized dietary advice helps people with early-stage type 2 diabetes control their blood sugar better than standard advice or usual care. About 255 participants were split into three groups: personalized diet, standardized diet, or usual care. Resea…

This study tested a culturally tailored program called Together Overcoming Diabetes (TOD) for American Indian families in Ojibwe communities. Adult caregivers with type 2 diabetes and their youth (ages 10-16) worked with local health coaches to set health goals. The program inclu…

This study tested whether making U.S. dietary guidelines more culturally relevant for African Americans could improve diet quality and reduce type 2 diabetes risk. 63 overweight or obese African American adults with at least three diabetes risk factors attended weekly classes for…

This study tested whether adding a smartphone app with short videos on mental health, diet, exercise, and insulin adjustment to standard care could improve blood sugar control and birth weight in pregnant women with diabetes. Over 600 women participated. The goal was to see if th…

This study tested two drugs—hydralazine-ISDN and metformin—in 1100 people with chronic heart failure and reduced heart function. Some participants also had diabetes or insulin resistance. The goal was to see if these drugs could lower the risk of death or hospital stays due to wo…

This Phase 3 study tested a new drug called IBI362 (mazdutide) against the well-known semaglutide in 349 Chinese adults with early type 2 diabetes and obesity. Participants received weekly injections for 32 weeks, with some continuing for an extra 24 weeks. The main goal was to s…

This study tested whether dapagliflozin, a drug used for type 2 diabetes, can lower blood pressure in people who have received a kidney transplant. Fifty-two participants took either the drug or a placebo for 12 weeks. The goal was to see if the drug helps control blood pressure …

This study looked at how safe a new once-weekly insulin (insulin icodec) is during exercise and long periods without food in 30 adults with type 2 diabetes. Participants first took a daily insulin for a week, then switched to the weekly insulin for up to 14 weeks. The goal was to…

This study tests a new medicine called SHR-3167 against a standard insulin (insulin glargine) for people with type 2 diabetes. About 275 adults who are not on insulin yet, but take metformin (alone or with another diabetes drug), will receive either SHR-3167 or insulin glargine. …

This study tested a new once-weekly injection called IcoSema, which combines two diabetes drugs (insulin icodec and semaglutide), against daily insulin glargine in 485 adults with type 2 diabetes whose blood sugar was not well controlled on oral medications. The goal was to see i…

This early study tested a single injection of a new drug called ENT-03S in 49 people who were either obese but otherwise healthy, or had both obesity and type 2 diabetes. The main goal was to check safety and how the drug moves through the body. Participants were randomly assigne…

This completed trial tested a new automated insulin delivery system called twiist in 307 adults with insulin-treated type 2 diabetes. The system combines an insulin pump, a continuous glucose monitor, and a smart algorithm to automatically adjust insulin. The main goal was to see…

This study tested a next-generation automated insulin delivery system in 48 adults with type 2 diabetes aged 16–70. The goal was to see if the smart algorithm could keep blood sugar in a safer range, reducing both low and high blood sugar events. Participants used a continuous gl…

This study tested three different diet plans in 108 overweight adults with type 2 diabetes to see which best improves blood sugar control. Participants followed either standard nutrition advice, a structured meal plan with special diabetes drinks, or that same structured plan plu…

This study looked at whether eating more dairy products (full-fat or low-fat) helps people with type 2 diabetes manage their blood sugar, weight, and heart health. 112 adults with type 2 diabetes who ate fewer than 3 servings of dairy per day were assigned to add either full-fat …

This study looked at whether starting tirzepatide, a once-weekly injection for type 2 diabetes, before Ramadan helps people manage their blood sugar safely while fasting. 166 adults with uncontrolled diabetes who planned to fast took part. Researchers measured changes in blood su…

This study looked at whether eating only within a 10-hour window each day helps overweight adults aged 50 to 75 with prediabetes lose fat and improve their metabolism. 57 participants either followed the 10-hour eating plan or their usual 13-hour eating pattern, while tracking th…

This completed phase 3 trial tested three doses of the oral drug HRS-7535 against a placebo in 284 adults with type 2 diabetes whose blood sugar was not well controlled by diet and exercise alone. The main goal was to see if HRS-7535 could lower HbA1c (a measure of average blood …

This study tested a weekly injection of semaglutide (2.4 mg) to help adults with overweight or obesity lose weight. About 242 people took part, comparing the drug to a placebo over roughly one year. The main goal was to see how much weight they lost and how many lost at least 5% …

This study looked at whether giving underserved patients with type 2 diabetes a continuous glucose monitor (CGM) plus monthly telehealth visits with a pharmacist helps them manage their blood sugar better. 46 adults with uncontrolled diabetes took part. Researchers compared those…

This pilot study tested whether using an automated insulin delivery (AID) system for just 10 days can help people with type 2 diabetes safely adjust their long-acting insulin doses. 23 adults who already used insulin injections took part. The goal was to see if the device was saf…

This study tested whether a short period of intensive insulin therapy, followed by a combination of basal insulin, metformin, and vildagliptin, could help people with poorly controlled type 2 diabetes simplify their long-term treatment. The goal was to see if more participants co…

This study looked at whether a DASH-style diet (modified for diabetes) combined with lower salt intake can lower blood pressure in adults with type 2 diabetes and high blood pressure. 105 participants ate specially prepared meals for 5-week periods. The goal was to find a practic…

This study tested a smartphone app called T2.coach that tracks diet, blood sugar, activity, and sleep, then uses machine learning to give personalized behavioral goals. About 280 adults with type 2 diabetes and high blood sugar used the app for 6 months alongside standard diabete…

This study looked at whether three different low-calorie diets could improve blood sugar and body composition in 120 shift workers who are overweight and have prediabetes or type 2 diabetes. Each diet had a different amount and timing of protein. The goal was to see which approac…

This study tested a phone-based program for 100 African Americans aged 50+ with poorly controlled type 2 diabetes. The program combined diabetes education and help with social needs like food or housing. Results aim to show if this approach improves blood sugar control and qualit…

This study tested whether taking a probiotic called Hafnia alvei HA4597 can help people lose more weight and control blood sugar better after gastric bypass surgery. 49 adults with obesity and type 2 diabetes took either the probiotic or a placebo twice a day for 90 days, startin…

This study looked at how well adults with obesity or complicated overweight could stick to different very low-calorie ketogenic diets (VLCKD) in a real-world clinic. Participants chose one of four diet plans, ranging from all-natural foods to all meal replacements, and followed a…

This study tested whether colchicine, a drug used for gout, can reduce inflammation in the arteries of people with diabetes who recently had a heart attack or stroke. Researchers used a special PET scan to measure inflammation in the blood vessels. 115 participants were randomly …

This study tested a new insulin (22011) to see if it works as well as an existing insulin (Ryzodeg) for people with type 2 diabetes. About 414 adults in China took part. The goal was to compare blood sugar control and safety. Results suggest the new insulin is a similar option fo…

This early study tested a single dose of the drug rongliflozin in 32 Chinese adults with type 2 diabetes who had normal, mildly, or moderately reduced kidney function. Researchers measured how the drug moved through the body and how it affected blood sugar and urine glucose. The …

This pilot study tested a 12-week phone program for 60 African American women aged 40-64 with type 2 diabetes and multiple caregiving responsibilities. Half received extra support for their caregiving stress plus diabetes education, while the other half got standard diabetes educ…

This study tested whether a form of vitamin B6 called pyridoxamine can improve the health of small blood vessels in people with type 2 diabetes. The researchers gave 40 participants either pyridoxamine or a placebo for a period, then switched treatments to compare effects. They m…

This study looked at whether a 12-week intensive lifestyle program focused on weight loss and diabetes control could improve diabetic peripheral neuropathy, a common nerve complication. Fifty adults with diabetes and a BMI between 30 and 45 took part. The program included diet, e…

This study tested a new investigational drug called CagriSema against a currently available medicine, tirzepatide, in over 1,000 adults with type 2 diabetes. The goal was to see which works better at lowering blood sugar and body weight. Participants received weekly injections of…

This study tested a once-daily pill called orforglipron in 559 adults with type 2 diabetes whose blood sugar was not well controlled by diet and exercise alone. The pill was compared to a placebo (a dummy pill) over about 54 weeks to see if it safely lowers blood sugar levels. Th…

This study tested a once-daily pill called orforglipron against insulin glargine in nearly 2,750 adults with type 2 diabetes, obesity or overweight, and increased cardiovascular risk. The main goal was to see if orforglipron could reduce major heart events like heart attacks or s…

This study looked at whether a 3-month supervised exercise program can improve blood sugar, body fat, and fitness in sedentary men aged 35-65 with type 2 diabetes, prediabetes, or overweight. Participants exercised at a fitness center under supervision. The goal was to see how di…

This study tested whether extra support from a pharmacist can help people with type 2 diabetes manage their blood sugar better. 122 participants were split into two groups: one got usual care, the other got usual care plus regular pharmacist sessions covering medication use, heal…

This study looked at how sitagliptin (Januvia) affects levels of anti-rejection drugs and blood sugar in 16 people who had a kidney transplant and have type 2 diabetes. Participants took sitagliptin daily for 3 months. The goal was to see if it is safe and works well in this grou…

This study tested a new investigational medicine called CagriSema in 189 adults with type 2 diabetes whose blood sugar was not well controlled by diet and exercise alone. Participants received either CagriSema or a placebo injection once a week for about a year. The main goal was…

This study tested whether a 6-week mindfulness program could help teens at risk for type 2 diabetes by reducing depression and insulin resistance. 120 teens aged 12-17 with overweight, a family history of diabetes, and elevated depression symptoms took part. They were randomly as…

This completed study tested whether a high-intensity medical weight loss program, supported by a digital platform and continuous glucose monitors, could help people with type 2 diabetes lose weight and achieve remission. 64 participants were enrolled and compared to a group recei…

This study tested whether a new medicine called CagriSema (a combination of two drugs) can reduce kidney damage in people with chronic kidney disease, type 2 diabetes, and overweight or obesity. About 626 participants received either CagriSema, one of the two drugs alone, or a pl…

This study tested a telenursing program that gave health education and lifestyle advice to 70 adults with type 2 diabetes in Bangladesh. Participants used their smartphones to get support from nurses on diet, exercise, and medication. The goal was to see if this approach could im…

This completed study looked at how two common diabetes drugs, dapagliflozin and empagliflozin, affect weight, cholesterol, and inflammation in 260 obese adults newly diagnosed with type 2 diabetes. Over six months, researchers measured changes in body weight, blood fats, and mark…

This study tested a virtual culinary medicine program for 89 adults with type 2 diabetes and elevated body mass index. Participants attended five online cooking and nutrition sessions, learning basic skills and healthy eating habits. Researchers measured changes in blood sugar (H…

This study tested whether a daily supplement of overripe banana powder can improve blood sugar control in adults with type 2 diabetes. Sixty participants took either the banana supplement or a standard formula for 12 weeks. Researchers measured changes in fasting blood sugar, HbA…

This study tested a continuous glucose monitor (CGM) that sends real-time blood sugar data to a cloud-based dashboard, allowing a remote team to manage high-risk type 2 diabetes patients in the hospital. Over 500 participants were assigned to either the active CGM system or usual…

This study tested whether eating tuna-based nuggets for three months could improve health in 120 people with heart disease and related conditions like obesity and diabetes. The nuggets were given as a source of selenium. Results showed improvements in some markers of inflammation…

This study looked at whether using a mobile app called Undermyfork along with a continuous glucose monitor (Dexcom G7) helps people with type 2 diabetes control their blood sugar better than standard care. About 91 adults with type 2 diabetes who were not on rapid-acting insulin …

This pilot study tested a new computer algorithm that uses continuous glucose monitor (CGM) readings to automatically suggest the right dose of long-acting insulin for people with type 2 diabetes. Thirty adults already using basal insulin were followed for 18 weeks to see if the …

This study compared two common diabetes drugs—dapagliflozin and metformin—in over 2,000 people with early type 2 diabetes (diagnosed less than 4 years). The goal was to see which drug better prevents serious complications like death, heart attack, stroke, heart failure, kidney di…

This study looked at 100 liver transplant patients with diabetes to see if dapagliflozin or sitagliptin is better at reducing liver fat and improving body composition. Participants took one of the two drugs for 12 months. The goal was to find a safer and more effective way to man…

This study tested a web-based app called Mobile Diabetes Detective (MoDD) in 248 adults with type 2 diabetes. The app helps users identify problems with blood sugar control and suggests better behaviors. Researchers measured changes in blood sugar (HbA1c), problem-solving skills,…

This early-stage study tested a new daily pill called LY3549492 in 36 Chinese adults with type 2 diabetes. The main goal was to check safety and side effects over about 18 weeks. Participants had diabetes for at least 6 months and were on diet, exercise, or stable metformin. This…

This study tested whether a longer intestinal bypass during stomach cancer surgery improves diabetes control better than the standard method. It included 94 adults with early-stage gastric cancer and type 2 diabetes. Researchers measured blood sugar and hormone levels one year af…

This pilot study tested two approaches to improve metabolic health in Black adults with stage 1 obesity and conditions like high blood pressure or prediabetes. Participants received either weight-focused or weight-neutral health coaching for 7 weeks. The goal was to see if a larg…

This study looked at whether a continuous glucose monitor (CGM) can help track blood sugar levels in 20 people with type 2 diabetes who had a kidney transplant. Participants wore a small sensor that measured glucose around the clock. The goal was to see how often blood sugar stay…

This study tested whether providing six months of diabetes-tailored meals and nutrition counseling can improve blood sugar control and reduce food insecurity in adults with type 2 diabetes. 281 participants received either the food support plus counseling or usual care. The main …

This study tested a home-based behavioral program called Home DM-BAT for low-income seniors with type 2 diabetes. Two hundred Black or Hispanic seniors aged 65 and older took part. The program involved 8 weekly in-home sessions and monthly booster calls to help improve blood suga…

This study tested a new insulin patch pump in 161 adults with type 1 or type 2 diabetes who needed intensive insulin therapy. Participants used either the new patch pump or a standard pump for 7 days in a hospital. Researchers measured changes in average blood sugar levels to see…

This completed study tested an AI-based system called X-Life that gives personalized lifestyle advice to adults with type 2 diabetes. The system uses glucose levels and wearable data to guide diet and activity. 124 participants were split into two groups: one using X-Life and the…

This study compared several common diabetes medications when added to metformin in 7,850 adults with type 2 diabetes. The goal was to see which combination best kept blood sugar under control over time. Results help doctors and patients choose the most effective treatment plan.

This study tested whether a virtual weight control program combined with a continuous glucose monitor could help adults with type 2 diabetes lower their blood sugar levels. 152 overweight or obese adults with type 2 diabetes participated. The program used the WW (Weight Watchers)…

This study tested a small, wearable sensor that sits just under the skin and measures blood sugar continuously for up to 5 days in adults with diabetes. 247 participants wore the sensor along with a standard monitor and took fingerstick tests to compare accuracy. The goal was to …

This completed study tested whether a new consultation method called M2-PRIME, which uses simple analogies like the 'Garbage and Lorry' model, could help people with type 2 diabetes on insulin improve their blood sugar control. 106 participants received three analogy-based consul…

This study tested a new medicine called CagriSema (a mix of two drugs) in 331 East Asian adults with obesity or overweight. Participants received a weekly injection for about 1.5 years. The main goal was to see how much weight they lost compared to another drug. The study is comp…

This study tested the safety and effectiveness of the Omnipod 5 SmartAdjust 2.0 system, an automated insulin pump, in 48 people aged 2 to 70 with type 1 or type 2 diabetes. The system uses a continuous glucose monitor to automatically adjust insulin delivery. The main goals were …

This study tested a new device, DyaMX, that uses an endoscope to regenerate the lining of the upper small intestine in people with type 2 diabetes. The goal was to see if the procedure is safe and can help improve blood sugar control. 65 adults with diabetes took part. The main f…

This study tested whether a daily semaglutide tablet helps Chinese adults with overweight or obesity lose weight. About 200 participants took either the drug or a placebo for 44 weeks, along with guidance on diet and exercise. The main goals were to measure the percentage of weig…

This study tested a program that combines diabetes coaching, small financial rewards, and continuous glucose monitoring to help adults with type 2 diabetes improve their blood sugar management. 26 participants used a continuous glucose monitor and received motivational interviews…

This study tested an experimental drug, MCI-196, in 183 people with type 2 diabetes to see if it could help control blood sugar and improve cholesterol levels. Participants took the drug or a placebo for 12 weeks. The goal was to measure changes in blood glucose and HbA1c, a key …

This study looked at whether doing calisthenic exercises (like bodyweight moves) through video calls with a physiotherapist could improve oxygen use, muscle health, and physical activity in adults with type 2 diabetes. Forty participants completed the program, exercising 30-45 mi…

This phase 2 study tested a new drug called teneligliptin (MP-513) in 324 Japanese adults with type 2 diabetes. Participants took one of three doses of the drug or a placebo daily for 12 weeks. The main goal was to see how well the drug lowered blood sugar levels (HbA1c) and to c…

This study looked at how three popular diets—Mediterranean, DASH, and MIND—affect blood sugar, cholesterol, and body measurements in people with type 2 diabetes. 90 adults completed surveys and had their weight, waist size, and lab values measured. The goal was to see which eatin…

This completed trial tested a low-AGE diet in 36 adults aged 55-65 with type 2 diabetes, coronary artery disease, and overweight. Participants were instructed to boil or steam food instead of frying, grilling, or roasting. The diet reduced blood levels of a harmful compound calle…

This study tested a new magnetic system that creates a shortcut in the small intestine to help people with obesity and type 2 diabetes. Fifteen adults aged 18-65 with a BMI of 30-35 and diabetes took part. The goal was to see if the device could safely create a lasting connection…

This study looked at whether alerts from continuous glucose monitors (CGMs) help hospital patients with type 1 or 2 diabetes manage their blood sugar better. Over 500 adults who needed intensive insulin therapy took part. The main goal was to see if alerts increased the time bloo…

This study tested a new insulin called THDB0206 against a standard insulin (lispro) in 1,040 Chinese adults with type 2 diabetes. Both were used alongside a long-acting insulin. The goal was to see if the new insulin works as well or better at controlling blood sugar over 26 week…

This study tested a new magnetic device that creates a connection between two parts of the small intestine, bypassing some of the digestive tract. The goal was to see if this procedure is safe and feasible for adults with obesity and type 2 diabetes. Only 9 people took part, and …

This study compared a new version of the Omnipod insulin pump (SmartAdjust 2.0) to the current Omnipod 5 in 132 people with type 1 or type 2 diabetes, ages 2 to 70. Participants used each system for about a month to see if the new one is safe and helps keep blood sugar in a healt…

This study tested a special diabetes education program for adults with type 2 diabetes and physical disabilities. The program included health coaching and educational materials, either through a tech platform or email. Researchers measured quality of life, distress, and self-conf…

This study looked at whether adding a nurse trained in diabetes care to the treatment team helps breast cancer patients with diabetes or prediabetes manage their blood sugar during cancer therapy. Researchers split 74 patients into two groups: one worked with the diabetes nurse, …

This completed trial tested two programs for older adults with type 2 diabetes: one with monthly phone coaching and one that added personalized referrals to community resources. Over 500 participants were followed for a year to see if these approaches helped lower blood sugar lev…

This completed study tested whether canagliflozin, a diabetes drug, can reduce scarring in the heart muscle of people with type 2 diabetes who are at high risk for heart problems. 45 participants were randomly assigned to take either canagliflozin or sitagliptin daily. Researcher…

This early study tested whether a protein called apelin can improve how the body uses insulin in people with type 2 diabetes. Nine volunteers received both apelin and a placebo infusion to compare effects. The goal was to see if apelin increases the amount of sugar the body can p…

This study checked if a new generic pill for type 2 diabetes (ertugliflozin/metformin) works the same as the brand-name drug (Segluromet). Thirty-six healthy adults took a single dose of each pill in random order. The goal was to see if the body absorbs both drugs at similar leve…

This Phase 2 trial tested a new drug called HRS-7535 in 155 adults with type 2 diabetes whose blood sugar was not well controlled despite taking metformin and an SGLT2i. Participants received either HRS-7535 or a placebo for 16 weeks. The main goal was to see if the drug could lo…

This study looked at whether regular follow-up visits with nurses and dietitians help people with type 2 diabetes manage their condition better. 398 adults with type 2 diabetes first received a week of education on diet and exercise. Then half were assigned to frequent check-ins …

This study tested a new investigational medicine called CagriSema, which combines two drugs (cagrilintide and semaglutide) in one weekly injection. It was given to 274 adults with type 2 diabetes who were already taking daily insulin, with or without metformin. The goal was to se…

This early-stage trial tested a new drug called CT-996 in 94 overweight or obese adults, including some with type 2 diabetes. The main goal was to check safety and how the body processes the drug. Researchers gave single or multiple doses and monitored side effects. This is a fir…

This study tested whether taking sodium butyrate tablets for 12 weeks, along with a modestly reduced-calorie diet, helps overweight or obese adults (with or without type 2 diabetes) lose more weight and improve blood sugar and fat levels compared to a placebo. 46 participants wer…

This study tested whether retatrutide, a medication being studied for weight loss, can help preserve kidney function in 146 adults who are overweight or obese and have chronic kidney disease (with or without type 2 diabetes). Participants received the drug or a placebo for about …

This study tested a 4-month online program that encourages a very low-carbohydrate breakfast for adults with poorly controlled type 2 diabetes. Researchers measured how satisfied participants were, how well they stuck to the diet, and changes in blood sugar, weight, and medicatio…

This study tested an automated insulin delivery system (the Omnipod 5) in 130 hospitalized adults with type 1 or type 2 diabetes. Patients were randomly assigned to use the automated system or standard insulin injections plus a continuous glucose monitor. The goal was to see if t…

This study compared two diets for people with type 2 diabetes: a very low-carbohydrate (keto) diet and a plate-method diet. Over 12 months, researchers tracked blood sugar control and body composition in 182 participants. The goal was to see which approach better improves diabete…

This study tested a connected insulin management platform in 36 people with type 1 or type 2 diabetes who use insulin. The goal was to see if the platform helped them take their insulin doses on time and keep their blood sugar in a healthy range. Participants used a continuous gl…

This study tested whether two types of intermittent fasting—eating very little a few days a week or eating only during an 8-hour window—can help people with type 2 diabetes improve their blood sugar control. Fifty-seven adults with diabetes followed one of these diet plans for a …

This Phase 3 trial tested the drug tirzepatide (a once-weekly injection) against a placebo in 206 Chinese adults with type 2 diabetes. The goal was to see if tirzepatide could safely lower blood sugar levels. Participants had to have stable weight and a BMI of 23 or higher. The s…

This study tested a once-daily pill called orforglipron in 546 adults with type 2 diabetes whose blood sugar was not well controlled despite using insulin (with or without other diabetes medications). The goal was to see if adding orforglipron could safely lower blood sugar level…

This study tested a program called ENACTS to help Native Hawaiian and Pacific Islander adults with high blood pressure or type 2 diabetes lower their blood pressure. The program included support for healthier eating, more physical activity, and working with grocery stores to labe…

This study tested a new once-daily pill called orforglipron against an existing drug, dapagliflozin, in adults with type 2 diabetes whose blood sugar was not well controlled with metformin alone. About 962 participants took either orforglipron or dapagliflozin for roughly 46 week…

This study tested whether taking flaxseed oil capsules (rich in alpha linolenic acid) for 24 weeks could improve blood sugar levels in 94 adults with elevated blood sugar or mild type 2 diabetes. Participants also had their gut bacteria and fatty acids measured. The goal was to s…

This study tested the Omnipod 5, a wearable device that automatically delivers insulin, in 343 adults with type 2 diabetes. Participants used the system for 13 weeks to see if it improved blood sugar levels. The goal was to make diabetes management simpler and more effective.

This early study tested a single injection of NEX-22A, a long-acting version of the diabetes drug liraglutide, in 12 adults with type 2 diabetes. The main goal was to see how the drug moves through the body and if it is safe. Participants were on stable metformin therapy and rece…

This phase 3 study tested a new once-daily pill called orforglipron against an existing oral semaglutide in nearly 1,700 adults with type 2 diabetes whose blood sugar was not well controlled on metformin. The main goal was to see how well orforglipron lowers blood sugar levels ov…

This study looked at whether moderate aerobic exercise or resistance exercise is better for improving bone density in postmenopausal women with type 2 diabetes and osteoporosis. Fifty women aged 50-60 did either treadmill walking or resistance training three times a week for 12 w…

This phase 3 study tested an experimental once-daily pill called orforglipron (LY3502970) against a placebo in 1613 adults who are overweight or have obesity and type 2 diabetes. The goal was to see if the drug helps with weight loss and improves blood sugar control. Participants…

This study tested whether taking magnesium oxide tablets (500 mg daily) for up to 12 months could improve blood sugar control in adults with type 2 diabetes. Researchers measured changes in HbA1c and fasting blood glucose, and tracked hospital visits. The goal was to see if magne…

This study tested whether adding a mangosteen supplement to standard diabetes drugs (sitagliptin/metformin) improves blood sugar control in 47 adults with type 2 diabetes. Participants took either the standard drugs alone or with mangosteen for 12 weeks. Researchers measured chan…

This trial tested a program where community health workers used a tablet app to screen pregnant women in rural India for anemia, high blood pressure, and diabetes. Over 3,400 women took part. The goal was to see if this screening and referral system could lower anemia rates and i…

This study looked at whether combining clinical Pilates, nurse coaching, and peer group work could improve general health in older adults with type 2 diabetes. 48 people aged 65 and older were split into four groups and followed for 12 weeks. Researchers measured things like anxi…

This study looked at whether drinking diet beverages (like diet soda) instead of water affects blood sugar control in adults with type 2 diabetes. 181 participants who regularly drank diet beverages were randomly assigned to keep drinking them or switch to plain water for 24 week…

This study tested whether taking a synbiotic (a mix of probiotics and prebiotics) for 6 months could improve blood sugar control, reduce inflammation, and change body composition in adults with prediabetes or type 2 diabetes. Researchers recruited 64 participants from a hospital …

This study uses machine learning to tell apart diabetic kidney disease from other kidney diseases in people with type 2 diabetes. Researchers analyzed data from over 2,200 patients across 14 medical centers to build a model that uses routine clinical and lab information. The goal…

This study tested whether computer analysis of voice recordings can detect type 2 diabetes. Over 7,000 adults in the UK recorded themselves reading and answering questions online. A subset also provided blood samples to check accuracy. The goal is to see if voice biomarkers could…

This study tested a new device called the Cmate blood glucose analyzer, which measures blood sugar without needing a finger prick. Researchers compared its readings to standard blood tests in 40 healthy, pre-diabetic, and diabetic adults. The goal is to see if this non-invasive m…

This completed study tested a 24-month program that combined face-to-face counseling with digital tools to help families prevent and manage type 2 diabetes and high blood pressure. Over 1,200 adults and their children from Albania, Bulgaria, Greece, and Spain took part. The progr…

This study looked at whether telling overweight East Asians their genetic risk for type 2 diabetes, combined with using a Fitbit, could encourage them to be more active. 355 participants aged 40-60 were split into groups: some got just a Fitbit, others got their genetic risk plus…

This study looked at whether taking vitamin D or fish oil supplements every day can help prevent type 2 diabetes. Over 22,000 adults without diabetes took part. Researchers tracked who developed diabetes over time to see if the supplements made a difference.

This study tested a special version of the Diabetes Prevention Program designed specifically for men. 301 men with pre-diabetes or high risk took part to see if the program helped them lose weight and prevent type 2 diabetes. The program focused on lifestyle changes and was deliv…

This study tested a mobile, web-based program called STEPS to help prevent type 2 diabetes in Hispanic adults living in rural areas. 179 participants at high risk for prediabetes were randomly assigned to use STEPS or receive usual care for three months. Researchers measured weig…

This pilot study tested a word game-based workbook to help people with diabetes learn about managing their condition, focusing on diet and carbohydrate control. 25 participants used the workbook during clinic visits or at home, completing puzzles and goal-setting exercises. The s…

This pilot study tested a mindfulness-based diabetes education program for adults with type 2 diabetes who feel overwhelmed by their condition. Thirty-six participants were randomly assigned to either the mindfulness program or standard diabetes education. The main goal was to se…

This study looked at whether progressive relaxation exercises can help people with type 2 diabetes who have nerve pain, fatigue, and poor sleep. 88 adults took part. The goal was to see if these simple exercises could improve their symptoms and quality of life.

This study tested whether using electrical stimulation on the thigh muscles could improve how the body uses insulin in people with type 2 diabetes. Eighteen adults with type 2 diabetes who were overweight and on oral medication received a single session and then six days of daily…

This study tested whether a 6-month exercise program called Vivifrail could improve physical function, thinking skills, and quality of life in 80 older adults (ages 60-80) with type 2 diabetes and frailty. Participants exercised three times a week, with increasing intensity over …

This study tested whether Baduanjin, a traditional Chinese exercise that combines gentle movements with mindful breathing, can help people with type 2 diabetes. 42 adults aged 50-60 with diabetes for 5-10 years took part. Researchers measured changes in blood sugar, quality of li…

This study tested whether the diabetes drug acarbose, adjusted using continuous glucose monitoring (CGM), can reduce pain in adults with painful diabetic neuropathy. 170 participants with type 2 diabetes and high blood sugar swings were enrolled. The goal was to see if controllin…

This study looked at whether drinking specialty coffee (a type high in a natural compound called chlorogenic acid) could improve memory, thinking speed, and attention in people with type 2 diabetes. Forty coffee drinkers with diabetes took part, drinking either specialty or regul…

This pilot study tested a digital program called FoodSteps for adults who struggle with binge eating, have type 2 diabetes, and face food insecurity. Participants used a mobile app and received coaching and a weekly stipend for 16 weeks. The goal was to see if the program is feas…

This small study tested whether gummy candies made with maqui berry could help overweight adults control their blood sugar after eating a carb-rich meal. Ten participants ate white bread alone, or with maqui berry gummies, and had their blood sugar and antioxidant levels measured…

This early-stage study tested a new drug called AZD5004 in 45 Chinese adults who were overweight or had obesity, with or without type 2 diabetes. The main goal was to check if the drug is safe and how the body processes it, compared to a placebo. Participants took the drug or a d…

This study tested a mindfulness program for 30 teens aged 12-18 with prediabetes or type 2 diabetes. The goal was to see if the program was practical and liked by teens, and to explore any effects on health measures like blood sugar. The approach involved group sessions and quest…

This study tested whether Buerger-Allen exercises, a series of leg movements done at home twice daily, can improve blood flow in people with type 2 diabetes. Researchers compared 74 participants who did the exercises plus routine care against those who only received routine care.…

This study tested whether daily text messages and small financial rewards could motivate overweight teens and young adults with prediabetes or type 2 diabetes to be more physically active. 75 participants wore a Fitbit and received different combinations of texts and incentives o…

This study tested a phone-based coaching program for veterans with type 2 diabetes who feel stressed or overwhelmed by daily self-care tasks like checking blood sugar and taking insulin. The program gave personalized advice and support to help reduce that stress and improve blood…

This study tested whether playing a board game called 'Let's Learn Diabetes' could lower anxiety and help people with type 2 diabetes better follow their insulin treatment. 72 adults aged 40-65 who recently started insulin were randomly assigned to either four weekly game session…

This study tests whether a lifestyle program held at senior centers can help older adults (age 60+) with type 2 diabetes improve their physical function and quality of life. About 20 participants will take part in the program, which includes education and activity sessions. The m…

This study analyzed health records from over 450,000 adults with obesity and type 2 diabetes to see if adding a GLP-1 or SGLT2 drug early improves survival and kidney health. Researchers compared those who added the other drug class within 90 days to those who added a different d…

This study looked at the genes and lifestyle of over 7,400 people in Nigeria to understand why some develop type 2 diabetes. Researchers compared people with and without diabetes to find genetic differences. The goal is to learn more about diabetes causes in African populations a…

This study looked at how a diabetes medicine called ertugliflozin affects fat tissue around the heart. Researchers took fat samples from 61 adults with type 2 diabetes and heart disease during heart surgery. They tested the fat in a lab to see if the drug improved how the fat cel…

This study looked at how quickly bringing high blood sugar under control, combined with moderate treadmill walking, affects certain proteins linked to bone health in people with type 2 diabetes. The goal was to understand why some patients develop a rare but serious joint conditi…

This study looked at 295 adults with type 2 diabetes in Kharga City, Egypt, to see how many also had other conditions like high blood pressure, heart disease, kidney disease, or eye problems. Researchers used blood tests, urine tests, and heart tracings to check for these issues.…

This study looked at the genes of 40 adults with type 2 diabetes to find DNA differences that might explain why some develop Charcot foot, a serious joint problem. Half of the participants had Charcot foot, and half did not. Researchers compared their exomes (the part of DNA that…

This study looked at 115 adults with prediabetes to understand why different people develop the condition. Researchers tested how each person's body responds to different foods, aiming to create personalized diet plans that prevent diabetes. The goal was to find biological marker…

This study looked at how much blood sugar levels go up and down during the day in frail or disabled patients over 75 with diabetes who use basal insulin. Researchers used a continuous glucose monitor for 5 days to compare two types of insulin: human NPH and long-acting analogues.…

This completed study surveyed over 4,600 people living with type 2 diabetes and multiple health conditions, along with their family members, to identify their health literacy strengths and needs. Participants answered a 44-question questionnaire about how well they understand and…

This completed study looked at 126 people with different fat distribution patterns—including those with lipodystrophy (abnormal fat loss or distribution), obesity, and normal weight—to understand how fat tissue relates to insulin resistance and immune signals. Researchers measure…

This study looked back at medical records of 2,740 adults with type 2 diabetes who were admitted to the ICU for septic shock, a life-threatening infection. Researchers wanted to see if those who were already taking metformin (a standard diabetes pill) before getting sick had a lo…

This completed study looked at insurance claims data from 70,000 people with type 2 diabetes and established heart disease to compare the heart-related risks of three diabetes drugs: tirzepatide, dulaglutide, and semaglutide. The goal was to see if any of these drugs was linked t…

This study looked at how different levels of exercise change the bacteria in the gut of people with type 2 diabetes. Forty adults with type 2 diabetes did either moderate or high-intensity endurance and strength training for 16 weeks. Researchers compared changes in blood sugar a…

This study looked at how short periods of low oxygen (from holding your breath) affect blood sugar levels after drinking a sugary drink. Researchers tested 20 healthy adults, people with prediabetes, and people with type 2 diabetes. The goal was to learn more about how oxygen lev…

This study tested a new way to help young adults (ages 18-30) with type 1 or type 2 diabetes move from pediatric to adult diabetes care. Researchers compared a collaborative care model to usual care, looking at how many visits patients completed and changes in diabetes-related di…

This study looks at how the body processes HRS9531, an experimental diabetes drug, in people with different levels of kidney function. Researchers gave a single dose to 32 volunteers—some with healthy kidneys and some with mild impairment—and measured drug levels over time. The g…

This study looked at whether shared medical appointments—where teens with type 2 diabetes meet together with their care team—are an acceptable way to deliver care. Researchers designed four group activities focused on nutrition, peer support, exercise, and stress management, and …

This study tested how easy and acceptable the P-STEP mobile app is for people with chronic conditions like asthma, COPD, heart disease, or diabetes. 178 adults in Leicester, UK used the app for 12 weeks to track their walking and get air quality updates. The main goal was to meas…

This study analyzed data from over 16,500 adults with chronic heart failure who were part of a remote monitoring program in France. Researchers looked at how having diabetes, other health conditions, and short-term weight changes were linked to survival. The goal was to better un…

This completed trial tested whether electronic alerts in the emergency room can improve care for people with type 2 diabetes. The alerts prompted doctors to order an A1c test when blood sugar was very high, and to consider admitting the patient for better diabetes management. Res…

This study worked with community groups to screen Hispanic/Latinx adults for kidney disease and diabetes, then referred them to a primary care doctor. It also gave local clinics guidelines to help doctors screen and treat Hispanic and Black patients with diabetes. The goal was to…

This study looked at two easy methods to measure hidden belly fat in 110 adults with type 2 diabetes. Researchers compared a simple waist measurement to a device that sends a mild electrical signal through the body. The goal was to see which method better relates to heart disease…

This pilot study tested whether continuous glucose monitors (CGMs) can help manage blood sugar in hospitalized adults with diabetes. Forty patients wore a Dexcom G6 device during their hospital stay to track glucose levels. The goal was to see if CGM could reduce dangerous low or…

This completed study analyzed health records from over 2 million people with type 2 diabetes to see if those taking dapagliflozin had a different risk of breast or bladder cancer compared to those on other diabetes medications. Researchers tracked cancer diagnoses for up to 12 ye…

This pilot study looked at whether removing oxysterols (harmful compounds in cooked animal foods) from the diet could improve insulin production in African Americans with prediabetes or early type 2 diabetes. Twelve participants ate a plant-based diet free of oxysterols for a per…

This study measured certain inflammatory markers in the saliva and blood of 126 people with type 2 diabetes, some of whom also had kidney disease (diabetic nephropathy). The goal was to see if these markers differ based on gum health. Researchers hope to better understand the lin…

This study looked at whether keeping indoor temperature at 26°C (about 79°F) can prevent dangerous heat strain in older adults during a multi-day heat wave. Researchers exposed 18 adults aged 60-85 to simulated heat conditions over three days and two nights, measuring core temper…

This study tested whether replacing sitting with standing or walking during daily life could improve blood sugar levels in South Asian adults who are overweight or obese. Eighteen participants followed two regimens: one with more sitting and one with less sitting. The goal was to…

This small pilot study looked at whether aprepitant, a drug used for nausea, can reduce aldosterone (a hormone that raises blood pressure) in people with type 2 diabetes and low-renin hypertension. Five participants took either aprepitant or a placebo for two weeks, then switched…

This study looked at how bariatric surgery changes the bacteria in the mouths of people with and without type 2 diabetes. Researchers collected blood and plaque samples before and after surgery from 102 participants. The goal was to understand if diabetes alters mouth bacteria in…

This study looked at 159 adults with type 2 diabetes to see if the way they are introduced to a continuous glucose monitor (CGM) affects their blood sugar control. One group received a nutrition-focused approach, while the other used a self-directed method. The main goal was to m…

This study looks at why dapagliflozin, a diabetes drug, can raise 'bad' cholesterol levels. Researchers will track how the body makes and clears cholesterol in 28 adults with type 2 diabetes over 6 months. Half the participants will get dapagliflozin, the other half a placebo. Th…

This study looked at how brown adipose tissue (brown fat) works in people with type 2 diabetes. Researchers used special PET scans with a fat-based tracer to measure brown fat activity more accurately than before. The study included 6 participants and aimed to better understand h…

This study looked at how diabetes changes the way certain fats (arachidonic acid) are processed in fatty plaques that build up in the carotid artery. Researchers compared plaque samples from 204 diabetic and non-diabetic patients undergoing surgery for carotid stenosis. The goal …

This study looked at a recently discovered hormone called 26RFa in 62 women who were obese, some with type 2 diabetes and some without. Researchers measured the hormone levels before and after weight-loss surgery (sleeve gastrectomy) and compared them to healthy-weight volunteers…

This study tested whether people with diabetes can use a smartphone game to monitor their vision at home, instead of always going to the clinic. 55 participants at high risk for diabetic retinopathy played vision games on their phones for 6 months. The goal was to see if people w…

This study explored whether personality type (A or B) and stress levels differ between people with type 2 diabetes who have foot wounds and those who do not. Researchers used questionnaires to measure personality, stress, depression, and quality of life in 66 participants. The go…

This study worked with Black adults aged 55 and older who have type 2 diabetes to understand why they sit for long periods and how to help them sit less. Researchers used interviews and activity monitors to learn about the social and personal factors that lead to prolonged sittin…

This study looked at how well 60 adults with type 2 diabetes could follow a Mediterranean diet for 12 months. Researchers wanted to see what makes it hard or easy to stick with this healthy eating plan. The goal is to find ways to help more people with diabetes adopt this diet.

This study looked at medical records of over 21,000 adults with type 2 diabetes and COPD to see if a diabetes drug called SGLT2 inhibitor lowers the chance of getting lung cancer compared to an older drug, sulfonylurea. Researchers did not give anyone new medicine; they just anal…

This completed study looked at whether the brain's central clock (the suprachiasmatic nucleus) works differently in people with insulin resistance or type 2 diabetes. Researchers used advanced MRI scans to measure brain activity over 24 hours in 28 obese adults with varying insul…

This study gathered information from 1,061 adults in Saudi Arabia about their weight, blood sugar, heart health, and lifestyle. The goal was to understand how common heart disease is in people with obesity. Participants filled out a questionnaire during a routine doctor visit, an…

This early-stage study tested a new experimental drug, NNC0113-6856, in 70 healthy men to see if it is safe and how the body processes it. Participants received either a single oral dose or an injection into the vein. The goal was to gather initial safety data and measure drug le…

This study looked at how a new drug combination called CKD-383 is absorbed and processed in the body. It involved 31 healthy adults who took the drug either as a single combined pill or as separate pills. The goal was to compare the two ways of taking the medication, not to treat…

This early-stage study looked at how a new combination diabetes drug, CKD-383, is processed by the body and whether it is safe. Thirty healthy adults took the drug as two tablets together or separately in a random order. The goal was to compare the two ways of taking the medicati…

This study looked at how a new combination diabetes drug, CKD-383, moves through the body compared to taking the individual drugs separately. It involved 30 healthy adults who received a single dose of each treatment in a random order. The goal was to measure drug levels and chec…

This study tested a new AI-assisted telehealth program designed to help adults with physical disabilities manage chronic conditions like heart disease, diabetes, and lung disease. Researchers wanted to see if the platform could improve quality of life, physical activity, and medi…

This completed study tested whether a smartwatch, combined with artificial intelligence, could identify digital signs of type 2 diabetes. Researchers gave 210 adults a multisensor watch to track heart rate and other vitals, then analyzed the data with machine learning. The goal w…

This study looked at whether chemicals in the breath (VOCs) match blood sugar levels in people with type 2 diabetes. Twenty adults with diabetes had their breath and blood sugar measured after drinking sugar water and receiving insulin. The goal was to see if a breath test could …

This completed study followed 1,290 adults with type 1 or type 2 diabetes for two years. Researchers tracked mental health issues like depression, anxiety, and eating problems alongside daily blood sugar levels using smartphone surveys and continuous glucose monitors. The goal wa…

This study tested whether a single, standardized MRI scan can reliably measure body composition and the health of multiple organs—like the liver, pancreas, heart, and kidneys—in people with type 2 diabetes and healthy volunteers. 43 participants were scanned twice on the same mac…

This study tested whether it is possible to run diabetes education workshops for inmates at Paris' La Santé prison. 22 men with type 1 or type 2 diabetes took part in group classes covering diet, foot care, and medication. The main goal was simply to see if prisoners would attend…

This study tested whether an 8-week individualized training program could improve heart and blood vessel function in men with obesity or type 2 diabetes. Researchers compared four groups: trained and untrained healthy volunteers, obese subjects, and diabetic patients. The goal wa…

This study looked at 500 women who had gestational diabetes during pregnancy. They took a glucose test 4 to 12 weeks after giving birth to see how many had type 2 diabetes, impaired glucose tolerance, or impaired fasting glucose. The goal was to compare women diagnosed with gesta…

This completed study looked at medical records from over 740,000 older adults with diabetes to see if those taking semaglutide had a lower risk of developing dementia compared to those on other diabetes drugs (DPP4 inhibitors). The goal was to find out if semaglutide might help p…

This study looked at how often older adults with diabetes in long-term care facilities experience low blood sugar (hypoglycemia). Researchers used a continuous glucose monitor (CGM) worn for 10 days to track blood sugar levels in 86 participants. The goal was to better understand…

This study looked at real-world medical records from over 887,000 people with type 2 diabetes, overweight, and heart risk to compare two drugs: tirzepatide and semaglutide. The goal was to see which one better prevents serious heart problems like heart attack, stroke, or death. T…

This completed study tested whether healthcare claims data can predict the results of a major heart trial (SURPASS-CVOT) comparing two diabetes drugs, tirzepatide and dulaglutide. Researchers analyzed records from over 44,000 people with type 2 diabetes and heart disease to see i…

This study looked at health records from over 386,000 adults with type 2 diabetes and moderate heart disease risk. Researchers compared four common second-line diabetes drugs to see which ones were linked to fewer heart attacks, strokes, and other complications. They also asked p…

This study tested whether a personalized lifestyle program could be run in a family medicine clinic for people with insulin resistance and related conditions like obesity, diabetes, and high blood pressure. Forty participants were randomly assigned to start with either nutrition …

This completed observational study examined whether semaglutide, a drug used for diabetes and weight loss, improves blood flow in the coronary arteries. Researchers measured coronary flow reserve in 122 diabetic and non-diabetic patients before and after 3 months of treatment. Th…

This completed study looked at how different pre-exercise meals affect blood sugar after exercise in 15 men with type 2 diabetes. Participants tried five conditions: fasting, or meals with added sucrose, fructose, fat, or aspartame, each followed by one hour of cycling. The goal …

This completed study in Cameroon followed 406 adults with and without type 2 diabetes for one year. Researchers tested blood and stool samples at four time points to see if diabetes increases the risk of malaria and other parasitic infections. The goal is to understand how non-co…