Gut check for gums: Surgery's surprising effect on mouth bugs

NCT ID NCT05501093

Completed Knowledge-focused Sponsor: University of Pennsylvania Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looked at how bariatric surgery changes the bacteria in the mouths of people with and without type 2 diabetes. Researchers collected blood and plaque samples before and after surgery from 102 participants. The goal was to understand if diabetes alters mouth bacteria in ways that could affect oral health.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this could reveal how diabetes-related changes in mouth bacteria affect oral health, pointing to new ways to prevent dental problems in people with diabetes.
What could go wrong: This is an observational study, not a treatment trial. It only looks at bacteria changes after surgery, so it cannot prove cause and effect or lead directly to a new therapy.

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Conditions

The condition(s) this trial relates to.

type 2 diabetes mellitus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BARIATRIC SURGERY CANDIDATE DIABETES TYPE2

Contacts and locations

Locations

Temple University

Philadelphia, Pennsylvania, 19104, United States
University of Pennsylvania

Philadelphia, Pennsylvania, 19104, United States

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