Which ketogenic diet works best? new study compares meal replacements vs. natural foods
NCT ID NCT07389122
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study looked at how well adults with obesity or complicated overweight could stick to different very low-calorie ketogenic diets (VLCKD) in a real-world clinic. Participants chose one of four diet plans, ranging from all-natural foods to all meal replacements, and followed a 26-week program. The goal was to see which diet had the best adherence, fewest side effects, and highest satisfaction, which could help personalize weight management strategies.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- very low-calorie ketogenic diet (VLCKD) with varying protein sources (natural foods vs. meal replacements)
- What this could lead to
- If successful, this study could help doctors and patients choose the most tolerable and effective ketogenic diet plan for weight loss and metabolic health.
- What could go wrong
- This is an observational study, not a controlled trial, so results may be influenced by personal preference. It is also small and single-center, limiting how widely the findings can be applied.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for INSULIN RESISTANCE are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
S.Orsola-Malpighi Hospital-University of Bologna
Bologna, BO, 40138, Italy
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Daily pill could offer new hope for weight loss in east asian adults
- Could a simple scan and blood test outsmart liver cancer?
- Seaweed extract may tackle fatty liver Disease—A trial puts it to the test
- Blood test could predict who faces rapid kidney decline in diabetes
- Blood test may predict kidney decline in diabetes — a large trial investigates
- Hormone clue may unmask kidney danger in diabetes