Brain clock may play role in diabetes risk

NCT ID NCT05314855

Completed Knowledge-focused Sponsor: Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This completed study looked at whether the brain's central clock (the suprachiasmatic nucleus) works differently in people with insulin resistance or type 2 diabetes. Researchers used advanced MRI scans to measure brain activity over 24 hours in 28 obese adults with varying insulin sensitivity. The goal was to understand how the brain clock might be involved in the development of insulin resistance.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this could help explain how the brain's internal clock affects insulin resistance and type 2 diabetes, pointing toward new treatment targets.
What could go wrong: This is a small observational study (28 people) that only measures brain activity, not a treatment. It may not lead to any direct medical changes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Insulin Resistance type 2 diabetes mellitus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

INSULIN RESISTANCE TYPE 2 DIABETES

Contacts and locations

Locations

Amsterdam University Medical Centers, location AMC

Amsterdam, North Holland, 1105AZ, Netherlands

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