Massive study reveals best diabetes drug combinations

NCT ID NCT01794143

Completed Disease control Sponsor: GRADE Study Group Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study compared several common diabetes medications when added to metformin in 7,850 adults with type 2 diabetes. The goal was to see which combination best kept blood sugar under control over time. Results help doctors and patients choose the most effective treatment plan.

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Conditions

The condition(s) this trial relates to.

type 2 diabetes mellitus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

COMPARATIVE EFFECTIVENESS OF GLYCEMIA-LOWERING MEDICATIONS TYPE 2 DIABETES

Contacts and locations

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Locations

Albert Einstein College of Medicine

The Bronx, New York, United States
Atlanta VA Medical Center

Decatur, Georgia, United States
Baylor College of Medicine

Houston, Texas, United States
Baylor Endocrine Center

Dallas, Texas, United States
Case Western Reserve University School of Medicine

Cleveland, Ohio, United States
Columbia University Naomi Berrie Diabetes Center

New York, New York, United States
Duke University Medical Center

Durham, North Carolina, United States
Indiana University School of Medicine

Indianapolis, Indiana, United States
International Diabetes Center

Minneapolis, Minnesota, United States
Kaiser Permanente Northwest

Portland, Oregon, United States
Kaiser Permanente of Georgia

Duluth, Georgia, United States
Massachusetts General Hospital

Boston, Massachusetts, United States
MedStar Health Research Institute

Hyattsville, Maryland, United States
Mount Sinai St. Luke's Hospital

New York, New York, United States
Oregon Health and Science University

Portland, Oregon, United States
Pacific Health Research and Education Institute (VA Pacific Islands)

Honolulu, Hawaii, United States
Pennington Biomedical Research Center

Baton Rouge, Louisiana, United States
Seattle Institute for Biomedical and Clinical Research

Seattle, Washington, United States
South Florida VA Foundation (Miami VA)

Miami, Florida, United States
Southwestern American Indian Center

Phoenix, Arizona, United States
State University of New York (SUNY)-Downstate Medical Center

Brooklyn, New York, United States
University of Alabama-Birmingham

Birmingham, Alabama, United States
University of Cincinnati

Cincinnati, Ohio, United States
University of Colorado

Denver, Colorado, United States
University of Iowa

Iowa City, Iowa, United States
University of Michigan

Ann Arbor, Michigan, United States
University of Minnesota

Minneapolis, Minnesota, United States
University of Nebraska

Omaha, Nebraska, United States
University of New Mexico School of Medicine

Albuquerque, New Mexico, United States
University of North Carolina Diabetes Care Center

Durham, North Carolina, United States
University of Texas Health Science Center

San Antonio, Texas, United States
University of Texas-Southwestern Medical Center

Dallas, Texas, United States
Vanderbilt University Medical Center

Nashville, Tennessee, United States
Veterans Medical Research Foundation, San Diego (San Diego VA)

San Diego, California, United States
Washington University School of Medicine

St Louis, Missouri, United States
Yale University School of Medicine

New Haven, Connecticut, United States

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