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Can two old drugs save heart failure patients?

NCT ID NCT03514108

Completed Disease control Sponsor: Henrik Wiggers Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested two drugs—hydralazine-ISDN and metformin—in 1100 people with chronic heart failure and reduced heart function. Some participants also had diabetes or insulin resistance. The goal was to see if these drugs could lower the risk of death or hospital stays due to worsening heart failure. The study was double-blind and placebo-controlled, meaning neither patients nor doctors knew who got the real drugs.

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Conditions

The condition(s) this trial relates to.

congestive heart failure diabetes mellitus heart failure Insulin Resistance type 2 diabetes mellitus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DIABETES HEART FAILURE

Contacts and locations

Locations

  • Aalborg University Hospital

    Aalborg, Denmark

  • Aarhus University Hospital

    Aarhus, Denmark

  • Amager Hospital

    Copenhagen, Denmark

  • Bispebjerg Hospital

    Copenhagen, Denmark

  • Gentofte Hospital

    Copenhagen, Denmark

  • Glostrup Hospital

    Copenhagen, Denmark

  • Herlev Hospital

    Copenhagen, Denmark

  • Herning Hospital

    Herning, Denmark

  • Holbæk Hospital

    Holbæk, Region Sjælland, Denmark

  • Holbæk Hospital

    Holbæk, Denmark

  • Horsens Hospital

    Horsens, Denmark

  • Hvidovre Hospital

    Copenhagen, Denmark

  • Kolding Hospital

    Kolding, Denmark

  • Nordsjællands Hospital Hillerød

    Hillerød, Denmark

  • Nykøbing Falster Hospital

    Nykøbing Falster, Denmark

  • Odense University Hospital

    Odense, Denmark

  • Randers Hospital

    Randers, Denmark

  • Regionshospital Nordjylland, Hjørring

    Hjørring, Denmark

  • Rigshospitalet

    Copenhagen, Denmark

  • Silkeborg Hospital

    Silkeborg, Denmark

  • Sjællands Universitetshospital, Roskilde

    Roskilde, Denmark

  • Slagelse Sygehus

    Slagelse, Denmark

  • Sydvestjysk Sygehus, Esbjerg

    Esbjerg, Denmark

  • Sygehus Sønderjylland, Aabenraa

    Aabenraa, Denmark

  • Vejle Hospital

    Vejle, Denmark

  • Viborg Hospital

    Viborg, Denmark

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