Diet soda vs. water: which is better for blood sugar?
NCT ID NCT03944616
First seen Jun 26, 2026 · Last updated Jun 26, 2026
Summary
This study looked at whether drinking diet beverages (like diet soda) instead of water affects blood sugar control in adults with type 2 diabetes. 181 participants who regularly drank diet beverages were randomly assigned to keep drinking them or switch to plain water for 24 weeks. The main goal was to see changes in HbA1c, a key measure of long-term blood sugar control.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- diet beverages (artificially sweetened) and water
- What this could lead to
- If it works, this could show that switching from diet drinks to water helps manage blood sugar in type 2 diabetes.
- What could go wrong
- This is a completed trial, but results may not apply to everyone. The effect may be small or not clinically meaningful.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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181 people
The number who actually took part.
- Started
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Jun 2019
- Finished
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Mar 2024
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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35 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion criteria: We will include men, women and non-binary participants with T2D, age 35 years and older, able to provide informed consent, otherwise healthy, who meet the following criteria: * Physician diagnosed type 2 diabetes ≥ 6 months prior to screening * HbA1c 6.5-8.5% at participant screening * Current treatment with lifestyle changes or stable diabetes-related medication levels for the past 3 months * Willingness to provide consent to contact treating physician and physician agreement to refrain from changing diabetes-related medications during the trial (change defined as \> 2 fold change in dose of any 1 hyperglycemic agent or addition or subtraction of an agent) * No physician-directed medication change for 3 months if prescribed medication for lipids or blood pressure * Usual consumers of diet beverages (≥ 3 servings/ week (24 oz.) and the willingness to maintain fidelity of the intervention, and participate in all aspects of the intervention * Not actively looking to make major lifestyle alterations during the study period with stable weight for 2 months (within 3%). Exclusion Criteria: * Type 1 diabetes or suspected type 1 diabetes (lean with polyuria, polydipsia, and weight loss with little response to metformin) * "Secondary" diabetes due to specific causes (e.g. monogenic syndromes, pancreatic surgery, and pancreatitis) * Diabetic Ketoacidosis hospitalization within last 6 months * Severe/major hypoglycemia in the last 3 months-severe/major hypoglycemia is defined as a hypoglycemic event in which patient requires assistance of another person to manage the episode * Glucocorticoid use (prednisone 2.5 mg/d or more or its equivalent) * History of intolerance or allergy to diet beverages or AS or phenylketonuria * Any condition that is known to affect the validity of the glycemic measures (Hba1c) * Major cardiovascular disease event or surgery within past 6 months * Gastrointestinal disease * Renal or liver disease * Current treatment for cancer * Those with major surgery planned or history of bariatric surgery * Antibiotic treatment (\> 6 days) within past 6 months * Currently pregnant (via self-report) or planning to become pregnant during study period; \<1 year postpartum and breast feeding * Current participation in another interventional clinical trial * Previous randomization in this study, * Heavy alcohol consumption (on average \>2 drinks/day for women and \>3 drinks/day for men) * Habitual consumer of SSB ≥ 1 serving / day (8 oz.) * Does not drink diet beverages * BMI \< 20.0 kg/m2
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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University of California, Irvine
Irvine, California, 92697, United States
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University of Minnesota
Minneapolis, Minnesota, 55454, United States
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