Diet soda vs. water: which is better for blood sugar?

NCT ID NCT03944616

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study looked at whether drinking diet beverages (like diet soda) instead of water affects blood sugar control in adults with type 2 diabetes. 181 participants who regularly drank diet beverages were randomly assigned to keep drinking them or switch to plain water for 24 weeks. The main goal was to see changes in HbA1c, a key measure of long-term blood sugar control.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
diet beverages (artificially sweetened) and water
What this could lead to
If it works, this could show that switching from diet drinks to water helps manage blood sugar in type 2 diabetes.
What could go wrong
This is a completed trial, but results may not apply to everyone. The effect may be small or not clinically meaningful.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

181 people

The number who actually took part.

Started

Jun 2019

Finished

Mar 2024

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

35 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion criteria: We will include men, women and non-binary participants with T2D, age 35 years and older, able to provide informed consent, otherwise healthy, who meet the following criteria: * Physician diagnosed type 2 diabetes ≥ 6 months prior to screening * HbA1c 6.5-8.5% at participant screening * Current treatment with lifestyle changes or stable diabetes-related medication levels for the past 3 months * Willingness to provide consent to contact treating physician and physician agreement to refrain from changing diabetes-related medications during the trial (change defined as \> 2 fold change in dose of any 1 hyperglycemic agent or addition or subtraction of an agent) * No physician-directed medication change for 3 months if prescribed medication for lipids or blood pressure * Usual consumers of diet beverages (≥ 3 servings/ week (24 oz.) and the willingness to maintain fidelity of the intervention, and participate in all aspects of the intervention * Not actively looking to make major lifestyle alterations during the study period with stable weight for 2 months (within 3%). Exclusion Criteria: * Type 1 diabetes or suspected type 1 diabetes (lean with polyuria, polydipsia, and weight loss with little response to metformin) * "Secondary" diabetes due to specific causes (e.g. monogenic syndromes, pancreatic surgery, and pancreatitis) * Diabetic Ketoacidosis hospitalization within last 6 months * Severe/major hypoglycemia in the last 3 months-severe/major hypoglycemia is defined as a hypoglycemic event in which patient requires assistance of another person to manage the episode * Glucocorticoid use (prednisone 2.5 mg/d or more or its equivalent) * History of intolerance or allergy to diet beverages or AS or phenylketonuria * Any condition that is known to affect the validity of the glycemic measures (Hba1c) * Major cardiovascular disease event or surgery within past 6 months * Gastrointestinal disease * Renal or liver disease * Current treatment for cancer * Those with major surgery planned or history of bariatric surgery * Antibiotic treatment (\> 6 days) within past 6 months * Currently pregnant (via self-report) or planning to become pregnant during study period; \<1 year postpartum and breast feeding * Current participation in another interventional clinical trial * Previous randomization in this study, * Heavy alcohol consumption (on average \>2 drinks/day for women and \>3 drinks/day for men) * Habitual consumer of SSB ≥ 1 serving / day (8 oz.) * Does not drink diet beverages * BMI \< 20.0 kg/m2

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • University of California, Irvine

    Irvine, California, 92697, United States

  • University of Minnesota

    Minneapolis, Minnesota, 55454, United States

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