Cooking method matters: simple diet change shows promise for diabetes and heart health

NCT ID NCT07303842

Completed Disease control Sponsor: InCor Heart Institute Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This completed trial tested a low-AGE diet in 36 adults aged 55-65 with type 2 diabetes, coronary artery disease, and overweight. Participants were instructed to boil or steam food instead of frying, grilling, or roasting. The diet reduced blood levels of a harmful compound called CML by 30%, which may help with insulin resistance and blood vessel health. While promising, the study was small and short-term, so more research is needed.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: low-advanced glycation end products (AGE) diet (boiling/steaming food, avoiding frying/grilling/roasting)
What this could lead to: If confirmed, this diet approach could help manage type 2 diabetes and reduce heart disease risk by lowering harmful compounds in the blood.
What could go wrong: This was a small, short-term study with only 36 participants. Long-term benefits and broader applicability are not yet proven.

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Conditions

The condition(s) this trial relates to.

coronary artery disorder type 2 diabetes mellitus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CORONARY ARTERY DISEASE (CAD) TYPE 2 DIABETES

Contacts and locations

Locations

Servico de Prevencao, Cardiopatia na Mulher e Reabilitacao Cardiovascular, Instituto do Coracao (InCor), Hospital das Clinicas HCFMUSP,

São Paulo, São Paulo, 05403- 900, Brazil

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