TYPE 2 DIABETES

This study is testing whether wearing a continuous glucose monitor (CGM) helps people with type 2 diabetes manage their blood sugar better after they leave the hospital. The research team will give 108 hospitalized patients with type 2 diabetes a CGM to wear for 12 weeks after di…

This study aims to see which of three newer diabetes medications (dulaglutide, semaglutide, and tirzepatide) works best to prevent serious heart problems like heart attacks and strokes in people with type 2 diabetes and overweight. It will analyze health insurance records from 60…

This study analyzes existing health insurance records to compare two common type 2 diabetes medications, oral semaglutide and sitagliptin. It aims to see which drug is more effective at preventing serious heart failure complications, like hospitalization, in people who have both …

This study is testing whether a high-tech coaching app can help people with type 2 diabetes better manage their condition, potentially reducing or eliminating their need for diabetes medications. The app, called a 'Whole Body Digital Twin,' uses AI to analyze daily data on diet, …

This study is testing two different diet coaching programs to help African American women better manage their type 2 diabetes. It involves 291 women who are at risk for diabetes complications. One group gets standard nutrition education, while the other gets the same education pl…

This study is testing the safety and effectiveness of a single injection that combines two diabetes medications (insulin glargine and lixisenatide) in adults with Type 2 diabetes. It is for people whose blood sugar is still not well controlled on their current pills or other inje…

This study compares two diabetes medications, tirzepatide and semaglutide, to see which works better at preventing heart failure hospitalizations and death in people who have both type 2 diabetes and a specific type of heart failure. Researchers will follow 26,000 patients using …

This study is testing whether higher doses of the medication tirzepatide can help people with both type 2 diabetes and obesity lose weight and better control their blood sugar. About 414 participants who are already taking metformin will receive either the study drug or a placebo…

This study is testing whether a new weekly injection called CagriSema works better than an existing drug called tirzepatide for controlling blood sugar and reducing weight in people with type 2 diabetes. About 1,000 adults whose diabetes isn't well-controlled on metformin will be…

This study is testing whether group prenatal care is better than traditional one-on-one visits for pregnant women with type 2 or gestational diabetes. It will compare how well each approach helps control blood sugar during pregnancy and manage weight after giving birth. The goal …

This study is testing if a new weekly injection called IBI362 works better than an existing drug, semaglutide, for people with early type 2 diabetes and obesity. About 349 Chinese adults will receive one of the two injections for 32 weeks to see which one helps more people reach …

This study is testing whether helping people with basic life needs—like getting enough food, stable housing, or transportation—can improve their health. It focuses on adults with type 2 diabetes and high blood pressure or cholesterol. Doctors will screen patients for these social…

This study is testing if adding a new drug called DA5221-T to two existing diabetes medications helps people with type 2 diabetes who still have high blood sugar. About 174 adults who are already taking the two-drug combo will receive either the new triple therapy or a placebo fo…

This study is testing how well the weekly injection tirzepatide works and how safe it is for adults with type 2 diabetes who plan to fast during the month of Ramadan. Researchers will measure changes in blood sugar control and body weight, and track any side effects like low bloo…

This study is testing a new magnetic device designed to make a type of weight-loss surgery safer and simpler. The device creates a connection in the small intestine to help with weight management and improve blood sugar control in adults with obesity, with or without type 2 diabe…

This study is testing whether a new pill combining three diabetes medicines works better and is safe for people with type 2 diabetes. It is for adults whose blood sugar is still too high even while taking a common medicine called metformin. Researchers will compare the new combin…

This study is testing a one-time, minimally invasive procedure called Revita Duodenal Mucosal Resurfacing (DMR) to see if it can help control blood sugar in adults with type 2 diabetes. Participants, whose diabetes isn't well-controlled with at least one standard medication, are …

This study is testing if a weekly injection of the medication semaglutide can help control blood sugar levels in people with type 2 diabetes who are receiving dialysis for kidney failure. Researchers will compare the injection to a placebo (dummy medicine) in about 43 participant…

This large study uses real-world insurance data to compare two weekly injectable diabetes medications, tirzepatide and dulaglutide. It aims to see which drug is better at preventing major heart problems like heart attacks and strokes in people who have both type 2 diabetes and es…

This study is testing whether a form of vitamin B6, called pyridoxamine, can help protect the tiny blood vessels in people with type 2 diabetes. It aims to see if the supplement improves blood vessel function in the eyes, kidneys, and skin, which are often damaged by high blood s…

This study is testing if offering cash payments to people with poorly controlled type 2 diabetes helps them better manage their condition. One hundred inner-city African American adults will be randomly assigned to receive cash either for attending virtual education classes or wi…

This study aims to see if continuous glucose monitors (CGMs) help low-income and uninsured adults with type 2 diabetes manage their condition better than traditional finger-prick meters. Researchers will enroll 50 patients with high blood sugar levels and follow them for six mont…

This study compares the long-term effectiveness and safety of the medication tirzepatide against intensified standard care in adults who were recently diagnosed with type 2 diabetes. It involves 780 participants who are currently only taking metformin. The main goal is to see if …

This study is testing a new support program to help African American and Latinx patients better manage their type 2 diabetes. It provides remote glucose monitoring, a support team, and tailored education to see if this approach improves blood sugar control more than standard care…

This study is testing whether a support team can help people with type 2 diabetes use continuous glucose monitors (CGMs) more effectively to control their blood sugar. It will involve 318 diverse, low-income patients who are not using insulin. The research will see if adding a cl…

This study is testing a new magnetic device designed to perform a type of weight-loss surgery. The device connects two parts of the intestine using magnets instead of traditional staples or stitches. Researchers want to see if this method is safe and works for helping adults with…

This study is testing a personalized mobile phone program designed to help adults manage type 2 diabetes. Over 500 participants will be randomly assigned to receive either this 12-month program—which includes coaching calls, daily texts, and goal-setting support—or standard educa…

This study is investigating whether the medication tirzepatide, which is approved for weight loss and diabetes, can improve kidney health in people who are overweight or obese and have chronic kidney disease. Researchers will use special MRI scans to see if the drug increases oxy…

This study is testing whether combining diabetes nutrition education with practical food support helps American Indian and Alaska Native adults better manage their type 2 diabetes. Researchers are working with a community clinic to offer some participants education, some food vou…

This study is testing whether eating dried Saskatoon berries daily can help people with prediabetes or newly diagnosed type 2 diabetes. Researchers will compare the effects of the berries against dried apples over 12 weeks in 92 participants. The main goal is to see if the berrie…

This study is testing whether an investigational medicine called cagrilintide helps people with type 2 diabetes and overweight or obesity lose weight and improve their health. About 330 participants will be randomly assigned to receive either the new medicine or a placebo for abo…

This study is testing whether a smartphone app called 'WellCheck' can help people with Type 2 diabetes better control their condition. About 470 patients will use the app, with one group getting extra support from their doctor through it. The main goal is to see if using the app …

This study tests a family-based program to help manage type 2 diabetes in Ojibwe communities. Adult caregivers with diabetes and their children work with local health coaches at home over six months. The goal is to see if this culturally tailored approach improves blood sugar con…

This study tests if simply wearing a continuous glucose monitor (CGM) that shows real-time blood sugar levels can help people with type 2 diabetes who don't use insulin. For two weeks, 120 participants will wear a CGM. For the first week, they won't see the readings; for the seco…

This large, late-stage study is testing whether a new once-daily pill called orforglipron is as safe and effective as standard insulin injections for adults with type 2 diabetes who also have obesity or are overweight and are at higher risk for heart problems. It will involve abo…

This study is testing a new weekly injection called petrelintide to see if it helps people with obesity and type 2 diabetes lose weight and better control their blood sugar. About 221 participants will receive either the drug or a placebo (dummy injection) for comparison. The mai…

This study is testing a new support program for young adults (ages 18-30) with type 1 or type 2 diabetes as they move from pediatric to adult healthcare. Researchers will compare this new program to standard care to see if it helps people keep doctor's appointments and reduces th…

This study is testing a new weekly injection called retatrutide for adults with type 2 diabetes and moderate to severe kidney problems. The goal is to see if it helps control blood sugar better than a placebo (dummy shot) in people who are already on insulin and possibly other di…

This study is testing a new automated insulin delivery system, called Twiist, for adults with type 2 diabetes who already use insulin. The main goal is to see if this system can control blood sugar levels as well as or better than the participants' current insulin methods. Resear…

This study is testing whether a diet personalized to an individual's unique gut microbiome can better control dangerous blood sugar spikes in people with early type 2 diabetes. About 300 participants are being assigned to either a standard diet, a personalized diet, or their usua…

This study is testing a 6-month lifestyle program held at senior centers to help older adults with type 2 diabetes improve their physical function and overall health. Researchers are working with 20 participants and community members to adapt proven health programs for use in loc…

This study is testing whether a daily pill called oral semaglutide, already used for type 2 diabetes, can also improve bone health. It will involve 64 adults aged 50-85 who have both type 2 diabetes and an increased risk of bone fractures. Participants will take either the real m…

This study is testing whether a new medication called SHR-3167 works as well as standard insulin injections for controlling blood sugar in people with type 2 diabetes. Researchers will compare both treatments in 275 adults who are already taking metformin but still need better bl…

This study is testing a new mobile phone program called STRIDE, designed to help adults with type 2 diabetes better manage their condition. The program provides support and aims to improve blood sugar control by involving a close friend or family member. Researchers want to see i…

This study is testing a specific screening method to find undiagnosed heart failure in people with diabetes who are at high risk. About 700 participants are being randomly assigned to either receive this new screening or continue with their usual care. The screening involves a bl…

This study is testing a new computer tool called MetSense. It alerts pharmacists when an adult with a serious mental illness (like schizophrenia or bipolar disorder) is at high risk for developing type 2 diabetes. The goal is to see if this alert helps pharmacists provide better …

This study tests whether a community-based exercise and healthy eating program during and after pregnancy can help prevent excessive weight gain, obesity, and type 2 diabetes in mothers and their children. It involves 1,000 pregnant women in urban areas who join before 20 weeks o…

This study is testing a 16-week family lifestyle program designed to prevent type 2 diabetes in Latino families at high risk. It involves 132 families with children aged 10-16 who have obesity. The program focuses on healthy eating, physical activity, and family support, comparin…

This study is testing whether a simple relaxation exercise program can help people with type 2 diabetes feel better. Researchers are looking at 88 participants to see if guided muscle relaxation can reduce nerve pain and fatigue, and improve sleep quality. The goal is to provide …

This study aims to better understand how amino acids (building blocks of protein) affect the release of two key hormones—glucagon and insulin—that control blood sugar. Researchers are comparing how people with type 2 diabetes, people with obesity, and healthy individuals respond …

This study aims to learn if surgery to remove overactive parathyroid glands (parathyroidectomy) helps improve blood sugar control and bone health in people who also have type 2 diabetes. Researchers will follow 80 patients for a year, comparing those who choose surgery to those m…

This study aimed to understand if a common type of diabetes medication (GLP1 agonists) helps keep blood vessels flexible after exercise in people with Type 2 diabetes. It planned to measure blood vessel stiffness and blood pressure in participants during and after a treadmill tes…

This study aims to see if analyzing existing health insurance records can produce results similar to a major clinical trial. Researchers are comparing the heart health outcomes of people with type 2 diabetes who took two different medications, dulaglutide and sitagliptin. The goa…

This study is checking back with 317 people who have type 2 diabetes to see how their liver health has changed over several years. Researchers are not testing a treatment; instead, they are using scans and blood tests to understand why some people develop serious liver disease an…

This study aims to understand why some people with diabetes develop serious heart and kidney problems while others do not. Researchers are collecting detailed health information and blood samples from 48,000 people with diabetes in Hong Kong to look for genetic and other biologic…

This study is exploring if a continuous glucose monitor (CGM) can help older adults with type 2 diabetes and mild memory problems manage their condition better when they share the data with a family member or caregiver. For two weeks, 10 older adults and their 10 helpers will use…

This study aims to find out how common fatty liver disease is in people who have type 2 diabetes. Researchers at a hospital in Belgium will use a special scan to check the livers of 385 adult patients with diabetes. The goal is to gather information to better understand the link …

This study aims to understand how specific genes influence how the body processes food and responds to metformin, a common diabetes medication. Researchers are enrolling 1,017 adults to eat a special test meal and take a single dose of metformin, then measuring blood sugar and ot…

This study is testing whether young people with type 2 diabetes will use a continuous glucose monitor (CGM) and if having this real-time data changes their behavior. About 30 participants, aged 8-20, will be split into two groups: one uses the CGM for 6 months, and the other uses…

This study aims to understand how a specific gene, PDE3B, affects how the body processes fats and sugars. Researchers will compare 40 people who have a version of this gene that may reduce its function to people with the typical version. By taking blood and small fat tissue sampl…

This study aims to understand how different dental cleaning techniques affect the body's immune response during a repeat root canal procedure. It will compare 90 participants—half with Type 2 diabetes and half without—to see if methods like ultrasonic or laser cleaning change inf…

This study is testing a new type of MRI scan to see if it can better identify which people with type 2 diabetes are most at risk for developing complications in their heart, liver, and kidneys. Researchers will follow 135 adults with type 2 diabetes for up to 5 years, comparing t…