TYPE 2 DIABETES

This study tests whether eating dried whole Saskatoon berries can improve blood sugar and cholesterol levels in adults with untreated prediabetes or early type 2 diabetes. About 92 participants will eat either Saskatoon berries or a control dried fruit daily for 10 weeks. Researc…

This study looks at whether a mobile app called 'Well Check' can help people with type 2 diabetes better control their blood sugar, blood pressure, and weight. About 471 adults will use the app, which connects to their electronic health records, while their doctors monitor progre…

This study looks at whether adding motivational interviewing to standard diabetes nutrition therapy helps African American women with type 2 diabetes improve blood sugar control and weight. About 291 women at risk for diabetes complications will take part in group nutrition sessi…

This study aimed to see if using an exercise phone app and a continuous glucose monitor could help teenagers with obesity, prediabetes, or type 2 diabetes lose weight and improve their health. Participants would have worn a glucose sensor and used the app with coaching support. H…

This study looks at whether attending prenatal care in a group setting helps pregnant women with type 2 or gestational diabetes better control their blood sugar and lose pregnancy weight after giving birth. About 117 women will be randomly assigned to either group care or traditi…

This study compares two diabetes medications, oral semaglutide and sitagliptin, in over 25,000 adults with type 2 diabetes and heart failure with preserved ejection fraction. The goal is to see which drug better prevents heart failure worsening, hospitalizations, or death. Resear…

This study tests a procedure that reroutes part of the small intestine to help control blood sugar in people with type 2 diabetes and obesity. About 15 participants will be followed for a year to see if their blood sugar and weight improve. The goal is better disease management, …

This study tests a procedure called duodenal mucosal resurfacing (DMR) to see if it can improve blood sugar control in people with type 2 diabetes. About 320 adults whose diabetes is not well managed with current medications will either receive the DMR procedure or a sham (fake) …

This study tests whether adding two new drugs (prusogliptin and dapagliflozin) to standard metformin can improve blood sugar control in adults with type 2 diabetes. About 815 participants who are not well-controlled on metformin alone will receive either the triple combination or…

This study tests a pre-mixed injection that combines two diabetes drugs (insulin glargine and lixisenatide) in adults with type 2 diabetes whose blood sugar is not well controlled by pills or other injectables. About 105 participants will receive the combo treatment to see if it …

This study tests a once-weekly injection called retatrutide in 320 adults with type 2 diabetes and moderate to severe kidney disease whose blood sugar is not well controlled despite using insulin. The drug is compared to a placebo over about 14 months to see if it safely improves…

This large Phase 3 study tests a once-daily tablet called orforglipron against a placebo in 1,200 adults with obesity or overweight, some of whom also have type 2 diabetes. The goal is to see if the drug helps with weight loss and is safe. Participants are split into two groups b…

This study tests whether a new tablet form of oral semaglutide (called D) works as safely and effectively as the current approved version for Japanese adults with type 2 diabetes. About 264 participants will be randomly assigned to receive either the new or the standard tablet fo…

This study tests whether the twiist automated insulin delivery system can help adults with type 2 diabetes who use insulin. The system automatically adjusts insulin delivery to keep blood sugar in a healthy range. Researchers will measure changes in blood sugar control (HbA1c) an…

This study tests different doses of the investigational drug tirzepatide in people with type 2 diabetes and obesity who are already taking metformin. The goal is to see if it helps with weight loss and blood sugar control. About 414 participants will be followed for 89 weeks to c…

This study tests a nutrition program made for Beninese adults with type 2 diabetes. 64 participants will either get the tailored program or usual care. The goal is to see if the program improves blood sugar and healthy eating over 6 months, with effects lasting up to a year.

This study tests whether semaglutide, a once-weekly injectable diabetes drug, can improve blood sugar control in people with type 2 diabetes who are on chronic dialysis. About 43 participants will be randomly assigned to receive either semaglutide or a placebo for 13 months. Bloo…

This study looks at whether wearing a continuous glucose monitor (CGM) after leaving the hospital helps people with type 2 diabetes control their blood sugar. About 108 adults who need insulin will wear a Dexcom CGM for 12 weeks and get personalized alerts. The goal is to see if …

This study tests a once-daily pill called orforglipron against a placebo in 600 adults with obesity or overweight who also have type 2 diabetes. The goal is to see if the pill helps lower blood sugar and body weight over about 18 months. Participants must have a BMI of 25 or high…

This study tests whether adding a third medication (DA5221-T) to an existing two-drug combo can improve blood sugar control in adults with type 2 diabetes. About 174 participants who still have high blood sugar despite taking two diabetes drugs will receive either the extra drug …

This early-stage study tests a new oral medication, ZE63-0302, in 60 adults with type 2 diabetes. The main goal is to check the drug's safety and how the body processes it. Participants must have had diabetes for at least 7 years and be on stable diabetes medicines (excluding ins…

This study tests a mobile phone program that changes over time to fit each person's needs, helping adults manage type 2 diabetes. About 547 participants will use the program or receive printed materials for 16 months. The goal is to see if the mobile program improves blood sugar …

This study tests an investigational medicine called cagrilintide to see how much it helps people with overweight or obesity and type 2 diabetes lose weight. About 330 adults will receive either cagrilintide or a placebo for around 18 months. The main goals are to measure the perc…

This study tests whether using an over-the-counter continuous glucose monitor (CGM) every 30 or 90 days helps people with type 2 diabetes who do not use insulin better manage their blood sugar. About 188 participants will wear the Dexcom Stelo sensor periodically over six months.…

This study looks at whether oral semaglutide, a daily pill for type 2 diabetes, can improve bone health in people aged 50-85 who have diabetes and weak bones. Over 52 weeks, researchers will measure bone turnover markers, bone density, and strength. The goal is to see if this dru…

This study looks at whether helping adults with type 2 diabetes, high blood pressure, or high cholesterol meet their social needs (like food, housing, or transportation) can improve their health. About 4,800 participants will be screened during clinic visits and offered support f…

This study compares two popular diabetes medications, tirzepatide and semaglutide, in 26,000 adults with type 2 diabetes and a specific type of heart failure (preserved ejection fraction). The goal is to see which drug better reduces the risk of hospitalization for heart failure …

This study tests a new weekly injection called IBI362 against the existing drug semaglutide in Chinese adults with early type 2 diabetes and obesity. The goal is to see if IBI362 is better at lowering blood sugar and helping people lose weight. About 349 participants will receive…

This study tests a new device that uses magnets to create a connection between two parts of the small intestine, bypassing a section to help with weight loss and blood sugar control. It involves 25 adults with obesity and type 2 diabetes. The goal is to see if the procedure is sa…

This study tests a once-weekly medicine called retatrutide in about 1000 adults with type 2 diabetes who are also overweight or have obesity. The goal is to see if it helps with weight loss and, for a smaller group, improves sleep apnea. Participants will receive either the drug …

This study tests whether giving cash payments to inner-city African Americans with poorly controlled type 2 diabetes can improve their blood sugar and quality of life. Participants are randomly assigned to receive money either for attending virtual diabetes education sessions or …

This study tests whether a special team-based program can help African American and Latinx adults with uncontrolled type 2 diabetes improve their blood sugar levels more than usual care. About 150 participants will either receive the team program or standard care with educational…

This study looks at whether starting tirzepatide before Ramadan helps adults with type 2 diabetes safely manage their blood sugar during the fasting month. About 130 participants who plan to fast will take the drug once weekly. Researchers will track blood sugar levels, weight ch…

This study tests a new weekly injection called petrelintide to help people with overweight or obesity and type 2 diabetes lose weight. About 221 adults will receive either the drug or a placebo for several weeks. The main goal is to see how much weight they lose and how their blo…

This study tests a new approach called the Twin Health Precision Treatment system, which creates a digital copy of each patient's body to guide personalized care for type 2 diabetes. 150 adults with diabetes will be randomly assigned to either this digital twin program or standar…

This study compares tirzepatide, a newer diabetes medication, with standard treatments in adults recently diagnosed with type 2 diabetes (within the last 4 years). About 780 participants who are already taking metformin will receive either tirzepatide or intensified conventional …

This study looks at whether support from clinical pharmacists and community health workers can help people with type 2 diabetes better manage their blood sugar using continuous glucose monitors (CGMs). About 318 adults aged 25-75 with high blood sugar will be enrolled. The goal i…

This study is testing a new magnetic system that creates a shortcut in the intestines to help people with obesity and type 2 diabetes lose weight and control blood sugar. Ten adults aged 18-65 with a BMI of 30-35 and type 2 diabetes will receive the device. The goal is to see if …

This study tests whether a computer tool that uses continuous glucose monitor (CGM) data can help primary care doctors make better decisions for people with type 2 diabetes who use insulin. About 150 adults with type 2 diabetes and high blood sugar will take part. The goal is to …

This study tests a culturally tailored, family-based program to help manage type 2 diabetes in Ojibwe communities. Adult caregivers with diabetes and their youth (ages 10-16) participate together in 14 lessons at home with a local health coach. The goal is to improve blood sugar …

This study looks at whether young people (ages 8-20) with type 2 diabetes will use a continuous glucose monitor (CGM) and if it helps them manage their blood sugar. About 30 participants will wear the device for 6 months, and researchers will track how often they use it and if th…

This study compares a new medicine, SHR-3167, with a standard insulin (insulin glargine) in 275 adults with type 2 diabetes who are not yet on insulin. Participants must be taking metformin (alone or with another drug) and have moderately high blood sugar. The main goal is to see…

This study looks at whether combining diabetes nutrition classes with a food security resource (like farmers market vouchers) can help American Indian and Alaska Native adults better manage their type 2 diabetes. About 67 participants will be split into three groups: some get bot…

This study tests whether tirzepatide, a drug used for diabetes and weight loss, can improve kidney function in 140 people with obesity and chronic kidney disease (with or without type 2 diabetes). Participants will have MRI scans to measure kidney oxygen levels and fat content ov…

This study is testing a new mobile phone program called STRIDE, designed to help adults with type 2 diabetes. The program aims to improve blood sugar management and provide social support by involving a close friend or family member. Researchers want to see if the program is easy…

This study tests a targeted screening approach to detect undiagnosed heart failure in 706 adults aged 40+ with type 1 or type 2 diabetes who also have additional heart risk factors. Participants are randomly assigned to receive the screening or usual care, and researchers track h…

This study tests whether a family-focused lifestyle program can lower type 2 diabetes risk and improve quality of life in high-risk Latino families. About 132 Latino children aged 10-16 with obesity take part. The program focuses on healthy eating and physical activity to prevent…

This study tests whether a diabetes risk alert can help pharmacists identify and screen younger adults with serious mental illness who are at high risk for type 2 diabetes. The goal is to prevent diabetes by prompting earlier screening and care. About 20,000 participants from Kai…

This study looks at whether a community-based diet and exercise program for pregnant women can lower the chances of obesity and type 2 diabetes in both mothers and their children. About 1,000 pregnant women in urban areas will take part during and after pregnancy. The goal is to …

This pilot study tests whether adding extra support—like pre-visit calls and follow-ups—to regular telemedicine visits helps adults with complex type 2 diabetes. About 50 participants who use insulin and have other health conditions will be followed for 6 months. The goal is to s…

This study looks at whether simply seeing real-time blood sugar readings on a continuous glucose monitor (CGM) can help people with type 2 diabetes who do not use insulin improve their blood sugar control. About 120 participants will wear a CGM for two weeks: the first week they …

This study tests a lifestyle program at senior centers to help adults aged 60 and older with type 2 diabetes improve their physical function and quality of life. About 20 participants will take part in group sessions focused on exercise and healthy habits. The goal is to see if t…

This study looks at how a small change in the PDE3B gene affects the way the body handles fat and sugar. Researchers will compare two groups of people—those with the gene change and those without—to see differences in fat tissue function and overall metabolism. The goal is to und…

This study examines whether removing overactive parathyroid glands (parathyroidectomy) improves blood sugar control in people with both type 2 diabetes and primary hyperparathyroidism. Researchers will also track changes in bone health. About 80 adults are being observed—some hav…

This study looks at how two different ways of cleaning infected root canals—using a special laser or ultrasound—affect the body's immune signals in people with and without type 2 diabetes. Researchers will measure certain immune markers in fluid samples from the tooth and gums. T…

This study looks at medical records from 60,000 people with type 2 diabetes and obesity to compare three drugs (dulaglutide, semaglutide, tirzepatide) against an older drug (sitagliptin) for preventing heart attacks, strokes, and death. The goal is to see which drug works best in…

This early-stage study looks at whether older adults (65+) with type 2 diabetes and mild memory issues can use a continuous glucose monitor shared with a care partner to better manage their diabetes. Fourteen participants and their care partners will use the device for two weeks,…

This study looks at health insurance claims from about 30,000 people with type 2 diabetes to see if they can get the same results as a famous clinical trial called REWIND. The goal is not to test a new drug, but to learn whether real-world data can be trusted to answer important …

This study looks at whether specific genes influence how people respond to a meal and a single dose of metformin, a common diabetes medication. Over 1,000 adults without diabetes will eat a special test meal and take metformin to measure changes in blood sugar and insulin. The go…

This study looks at why some people with type 2 diabetes don't get the full benefits of exercise. Researchers will measure how well cells produce energy before and after exercise training. The goal is to find factors that block exercise's positive effects, which could lead to bet…

This study is creating a large biobank of health information and blood samples from 48,000 people with diabetes in Hong Kong. Researchers will analyze genes and other markers to better predict who is at risk for serious complications like kidney failure, heart disease, and stroke…

This study looks at how amino acids change the way the body releases glucagon and insulin when blood sugar is high. Researchers will compare healthy people, those with type 2 diabetes, and people with obesity. The goal is to better understand these hormone responses, not to test …

This study re-examines 317 adults with type 2 diabetes who were first checked for fatty liver disease a few years ago. Researchers will use advanced scans and blood tests to see if their liver condition has improved, worsened, or stayed the same. The goal is to find patterns and …

This study follows 135 adults with type 2 diabetes over 75 months to see if MRI scans can predict who will develop kidney, liver, or heart problems. Participants undergo special MRI scans, and results are compared with healthy people. The goal is to better identify risks early, b…

This study looks at whether continuous glucose monitors (CGMs) can help underserved adults with type 2 diabetes better manage their blood sugar. About 50 people with high A1c levels will use a CGM for 6 months, and researchers will track changes in blood sugar control and any pro…

This study aimed to see if GLP1 agonists change how stiff arteries become after exercise in people with type 2 diabetes. Researchers planned to measure artery stiffness and blood pressure during a treadmill test. The study was withdrawn before enrolling anyone, so no results are …

This study looks at how exercise training changes the way muscles and fat tissue respond to insulin in people with type 2 diabetes. Researchers will use PET scans and small tissue samples to measure glucose uptake and energy use. The goal is to better understand the benefits of e…

This study aims to find out how many people with type 2 diabetes also have non-alcoholic fatty liver disease (NAFLD). Researchers will use a special ultrasound scan (FibroScan) to check the liver health of 385 adults with type 2 diabetes. The goal is to better understand how ofte…