Fish oil and Aspirin-Like drug may ease diabetic nerve pain

NCT ID NCT05169060

Ongoing Disease control Sponsor: University of Iowa Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This early study tests whether fish oil, alone or with salsalate (an anti-inflammatory drug), can improve blood markers linked to nerve health in people with type 2 diabetes and diabetic neuropathy. About 100 adults will take fish oil capsules for 4 months, then add salsalate for 2 more months. The goal is to see if this combination safely increases anti-inflammatory substances in the blood, which could eventually lead to a treatment for nerve damage.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Fish oil and salsalate
What this could lead to: If it works, this could point toward a new treatment for diabetic nerve pain and damage.
What could go wrong: This is a very early, small study (100 people) looking at blood markers, not symptoms. The combination may not actually help nerve pain or could cause side effects like stomach issues.

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Conditions

The condition(s) this trial relates to.

diabetes mellitus diabetic neuropathy Inflammation type 2 diabetes mellitus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DIABETIC NEUROPATHIES

Contacts and locations

Locations

Oregon Health Science University

Portland, Oregon, 97239, United States
University of Iowa

Iowa City, Iowa, 52241, United States

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