Parathyroid surgery may help control diabetes, study suggests

NCT ID NCT05761743

Ongoing Knowledge-focused Sponsor: The Cleveland Clinic Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looks at whether removing overactive parathyroid glands (parathyroidectomy) can improve blood sugar control in people who also have type 2 diabetes. Researchers will compare 80 patients who have surgery with those who do not, measuring changes in blood sugar and bone health. The goal is to understand if treating hyperparathyroidism can also help manage diabetes.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: parathyroidectomy (surgery to remove overactive parathyroid glands)
What this could lead to: If successful, this study could show that parathyroid surgery improves blood sugar control in people with type 2 diabetes, pointing toward a new way to manage both conditions.
What could go wrong: This is an observational study, not a treatment trial, so it cannot prove cause and effect. Results may not apply to all patients, and surgery carries standard risks like infection or bleeding.

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Conditions

The condition(s) this trial relates to.

hyperparathyroidism primary hyperparathyroidism type 2 diabetes mellitus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PRIMARY HYPERPARATHYROIDISM TYPE 2 DIABETES

Contacts and locations

Locations

Cleveland Clinic Main Campus

Cleveland, Ohio, 44195, United States

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