Can a weekly shot help dialysis patients control diabetes?

NCT ID NCT06042153

Ongoing Disease control Sponsor: University of Texas Southwestern Medical Center Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether semaglutide, a once-weekly injection, can improve blood sugar control in people with type 2 diabetes who are on chronic dialysis. About 43 participants will receive either semaglutide or a placebo for over a year, and their blood sugar levels will be tracked using a continuous glucose monitor. The goal is to see if semaglutide helps keep blood sugar in a healthy range without causing dangerous lows.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Semaglutide
What this could lead to: If it works, this could offer a new way to manage blood sugar in people with diabetes who are on dialysis, potentially improving their health and quality of life.
What could go wrong: This is a small, early-phase study with only 43 participants, so results may not apply to everyone. Semaglutide can cause side effects like nausea or vomiting, and its safety in dialysis patients is not fully known.

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Conditions

The condition(s) this trial relates to.

end stage renal failure type 2 diabetes mellitus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

END STAGE RENAL DISEASE ON DIALYSIS TYPE 2 DIABETES

Contacts and locations

Locations

DaVita UT Southwestern - East Dallas

Dallas, Texas, 75228, United States
DaVita UT Southwestern - Irving

Irving, Texas, 75062, United States
DaVita UT Southwestern - Preston

Dallas, Texas, 75240, United States
Davita UT Southwestern - Oak Cliff

Dallas, Texas, 75224, United States
University of North Carolina

Chapel Hill, North Carolina, 27599, United States

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