Could a higher dose of tirzepatide tackle diabetes and obesity together?

NCT ID NCT06037252

Ongoing Disease control Sponsor: Eli Lilly and Company Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This phase 2 trial tests different doses of tirzepatide in 414 adults with type 2 diabetes and obesity who already take metformin. The goal is to see if the drug helps with weight loss and blood sugar control. Participants receive either tirzepatide or a placebo for about 89 weeks.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: tirzepatide
What this could lead to: If successful, this could lead to a new treatment option that helps people with type 2 diabetes and obesity lose weight and better control their blood sugar.
What could go wrong: This is a phase 2 trial, so it's still early. The drug may not work better than placebo, and side effects are possible. Results may not apply to everyone with diabetes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Body Weight diabetes mellitus endocrine system disorder glucose metabolism disease metabolic disease nutritional disorder Obesity obesity disorder overnutrition type 2 diabetes mellitus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

OBESITY TYPE 2 DIABETES

Contacts and locations

Locations

AGILE Clinical Research Trials, LLC

Sandy Springs, Georgia, 30328, United States
Accellacare - Wilmington - 1917 Tradd Court

Wilmington, North Carolina, 28401, United States
Acibadem Universitesi Atakent Hastanesi

Istanbul, 34303, Turkey (Türkiye)
Akdeniz Universitesi Hastanesi

Antalya, 07070, Turkey (Türkiye)
Alta Pharmaceutical Research Center

Norcross, Georgia, 30092, United States
American Research Centers of Florida

Pembroke Pines, Florida, 33027, United States
Baskent Universitesi Adana Dr. Turgut Noyan Uygulama ve Arastirma Merkezi

Adana, 01250, Turkey (Türkiye)
CEDIC

CABA, Buenos Aires, C1060ABN, Argentina
Care Access - Aurora

Aurora, Colorado, 80012, United States
Care Access - Sacramento

Sacramento, California, 95831, United States
Centro Especializado En Diabetes, Obesidad Y Prevencion De Enfermedades Cardiovasculares

Mexico City, Mexico City, 11650, Mexico
Centro Medico Dra. Laura Maffei- Investigacion Clinica Aplicada

Buenos Aires, Buenos Aires F.D., C1425AGC, Argentina
Centro Médico Viamonte

Buenos Aires, Buenos Aires F.D., C1120AAC, Argentina
Centro de Estudios de Investigacion Metabolicos y Cardiovasculares

Ciudad Madero, Tamaulipas, 89440, Mexico
Centro de Investigacion Cardiovascular y Metabólica

Tijuana, Estado de Baja California, 22500, Mexico
Centro de Investigaciones Metabólicas (CINME)

Buenos Aires, C1056ABI, Argentina
Charlottesville Medical Research

Charlottesville, Virginia, 22911, United States
Chase Medical Research, LLC

Waterbury, Connecticut, 06708, United States
Clinical Research Associates Inc

Nashville, Tennessee, 37203, United States
Consultorio de Investigación Clínica EMO SRL

Ciudad Autonoma de Buenos Aires, Buenos Aires, 1405, Argentina
Cryptex Investigación Clínica S.A. de C.V.

Cuauhtémoc, Ciudad de México, Mexico City, 06100, Mexico
Dicle Üniversitesi

Diyarbakır, 21100, Turkey (Türkiye)
Gaziantep Universitesi Sahinbey Arastirma ve Uygulama Hastanesi

Gaziantep, 27310, Turkey (Türkiye)
Hospital Universitario "Dr. Jose Eleuterio Gonzalez"

Monterrey, Nuevo León, 66460, Mexico
Integrated Clinical Trial Services, Inc.

West Des Moines, Iowa, 50265, United States
John Muir Physician Network Research Center

Concord, California, 94520, United States
Juno Research

Houston, Texas, 77040, United States
Marmara Universitesi Pendik Egitim Arastirma Hastanesi

Istanbul, 34899, Turkey (Türkiye)
Medical Advancement Centers of Arizona

Phoenix, Arizona, 85044, United States
Northwest Clinical Research Center

Bellevue, Washington, 98007, United States
Northwestern University

Chicago, Illinois, 60611, United States
Ondokuz Mayıs Universitesi

Samsun, 55139, Turkey (Türkiye)
Qualmedica Research, LLC

Evansville, Indiana, 47715, United States
Retreat Medical Research

Miami, Florida, 33135, United States
Southern Endocrinology Associates

Mesquite, Texas, 75149, United States
Summit Headlands

Portland, Oregon, 97210, United States
TC Saglik Bakanligi Goztepe Prof. Dr. Suleyman Yalcin Sehir Hastanesi

Kadıköy, Istanbul, 34722, Turkey (Türkiye)
Uludag Universitesi

Bursa, 16059, Turkey (Türkiye)
Velocity Clinical Research, Mt. Auburn

Cincinnati, Ohio, 45219, United States
Virgen Cardiovascular Research SC

Guadalajara, Jalisco, 44670, Mexico

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