TYPE 2 DIABETES

This study will see if a program called HEARTS helps people who have both high blood pressure and diabetes get better care. About 1,440 adults in Guatemala will take part. Some clinics will use the HEARTS program, while others will continue their usual care. The study will check …

This study tests whether a special education plan using continuous ketone monitoring can lower the risk of diabetic ketoacidosis (DKA) in people with type 1 diabetes who also take SGLT2 inhibitors. About 75 adults with type 1 diabetes will be enrolled. The goal is to see if this …

This study tests a new medicine called HDM1005 against an existing drug, mazdutide, in about 900 adults with type 2 diabetes whose blood sugar is not well controlled by metformin alone or with another diabetes pill. The goal is to see which drug works better at lowering blood sug…

This study tests if a drink called A1Cantus can help lower blood sugar levels (A1C) in adults with type 2 diabetes. About 50 people will drink either the special drink or a placebo for 3 months, and neither they nor the researchers will know which they get. The goal is to see if …

This study tests a program that combines peer support with remote patient monitoring to help Black adults with uncontrolled type 2 diabetes. About 200 participants will use the program for 6 months, and researchers will track changes in blood sugar and blood pressure. The goal is…

This study compares two common diabetes drugs, dapagliflozin and empagliflozin, in adults with type 2 diabetes and a high body mass index. Researchers will measure changes in blood sugar, weight, liver and kidney function, blood pressure, and cost over six months. The goal is to …

This study compares two telehealth approaches—digital health coaching and remote patient monitoring—to see which works best for managing type 2 diabetes in people with physical disabilities and at least one other chronic condition. About 5,000 participants will be followed for 12…

This study looks at whether a probiotic called Lactobacillus paracasei LC19 can help control blood sugar in people recently diagnosed with type 2 diabetes. About 70 adults who have not taken diabetes medication will take the probiotic daily for 12 weeks. Researchers will measure …

This study looks at whether walking for 20 minutes after each meal can improve blood sugar control in pregnant women with type 2 diabetes. About 40 women will be split into two groups: one that walks after meals and one that does not. The goal is to see if this simple activity he…

This study will adapt a community health worker-led program to help South Asians with type 2 diabetes who are at risk for depression. The program includes mental health support and digital tools, using a trauma-informed approach. Researchers will test if the program is feasible a…

This study tests a new once-weekly injection, HS-20094, against an existing drug (dulaglutide) for people with type 2 diabetes whose blood sugar is not well controlled by metformin alone or with SGLT2 inhibitors. About 546 adults will receive one of the two treatments for 44 week…

This pilot study tests whether home-based high-intensity interval training (HIIT) can help people who have reversed their type 2 diabetes keep it from returning. Researchers will recruit 20 adults who completed the NHS Path to Remission programme and achieved diabetes remission. …

This study looks at whether playing active video games can help children, teenagers, and young adults (ages 5-21) with obesity and type 2 diabetes lose weight and improve their blood sugar levels. Participants will play active video games at home, and researchers will track chang…

This study is testing whether a new drug called CS0159, when combined with the diabetes drug semaglutide, can help people with fatty liver disease, obesity, and type 2 diabetes. About 30 adults will take the combination or a placebo for 12 weeks. The main goals are to see if it h…

This study looks at whether eating whole fruit can help adults with type 2 diabetes better control their blood sugar, reduce liver fat, and lower heart disease risk. Researchers will enroll 25 people who do not use insulin and monitor their glucose levels, insulin sensitivity, an…

This study tests whether an automated insulin delivery system (a smart pump that adjusts insulin automatically) can help people with type 2 diabetes and kidney failure who are on dialysis. About 84 participants will either use the automated system or continue their usual insulin …

This study looks at two diabetes medications, cofrogliptin and linagliptin, when added to insulin therapy in Chinese adults with type 2 diabetes. The goal is to see which one works better at controlling blood sugar and is safer. About 594 participants will take either cofroglipti…

This study tests a new medicine called CagriSema to see how well it helps people with obesity lose weight, compared to an existing drug, semaglutide. About 2500 adults with a BMI of 35 or higher, with or without type 2 diabetes, will take part. The trial lasts 83 weeks and measur…

This study tests a program that delivers fresh produce to the homes of pregnant women with type 1 or 2 diabetes who also struggle to get enough healthy food. Participants will also receive group education on diabetes, nutrition, and cooking, plus ongoing support for other needs. …

This study tests a new medicine called cofrogliptin against an older one, acarbose, in 200 adults with type 2 diabetes who have never taken diabetes drugs. The goal is to see which works better at lowering blood sugar and has fewer side effects. Participants will take one of the …

This study tests whether using a continuous glucose monitor (CGM) helps more people with type 2 diabetes achieve remission compared to standard finger-prick testing. About 176 adults will follow a low-calorie meal replacement plan and diabetes education for 18 months. The goal is…

This study tests whether a personalized diet plan, guided by continuous glucose monitors, can help Chinese and Vietnamese Americans better manage type 2 diabetes. About 120 participants will be split into two groups: one gets the adaptive diet plan plus the monitor, the other get…

This study tests an investigational injection called HS-20094 in adults with type 2 diabetes whose blood sugar is not well controlled by diet and exercise alone. About 204 participants will receive either the drug or a placebo to see if it safely lowers blood sugar over 44 to 52 …

This study tests whether the drug denosumab can help prevent bone fractures in people with type 2 diabetes who are at high risk for osteoporosis. About 358 adults aged 50 and older (or postmenopausal women aged 45+) will receive denosumab or a placebo. The goal is to see if the d…

This study looks at how safe and effective the Endogenex System is for people with type 2 diabetes. It includes 50 adults who previously received a sham (fake) treatment in an earlier study. The main goal is to track any serious side effects related to the device or procedure.

This study looks at whether supervised exercise and a diabetes drug called semaglutide can help older adults with type 2 diabetes keep their thinking skills sharp. About 164 people aged 65 and older will be placed into four groups: exercise only, semaglutide only, both, or standa…

This study looks at whether starting four approved kidney medicines quickly (over about 8 weeks) is safe and works better than the usual step-by-step method in people with type 2 diabetes and chronic kidney disease. About 64 adults will be randomly assigned to either the rapid-st…

This study compares two ways to manage diabetes after hospital discharge: a continuous glucose monitor (CGM) that checks sugar levels automatically versus traditional fingerstick checks. About 64 adults with type 2 or steroid-induced diabetes will wear a sensor for 28 days and ha…

This study tests if montelukast, a medicine used for asthma, can help protect the kidneys and blood vessels in teens and young adults (ages 14-24) with type 2 diabetes. The drug works by blocking inflammation that can harm these organs. Researchers will measure changes in kidney …

This study tests whether a natural fiber called oligofructose (found in onions, garlic, and bananas) can help improve blood sugar, cholesterol, and inflammation in Saudi adults with type 2 diabetes. 100 adults (50 with diabetes and 50 without) will take either the prebiotic or a …

This study will compare two types of continuous glucose monitors (real-time vs intermittent) in 108 adults with type 2 diabetes who use insulin and have poor blood sugar control. Participants will be randomly assigned to one monitor type for several months. The goal is to see whi…

This study compares a new injectable medication called iGlarLixi against standard diabetes treatments for adults with type 2 diabetes whose blood sugar is not well controlled with oral pills. About 1,316 participants in China will be randomly assigned to receive either iGlarLixi …

This study compares a new medicine called QLG1091 to an existing drug, Rybelsus, in people with type 2 diabetes who already take metformin. About 478 adults will receive either QLG1091 or Rybelsus for 26 weeks to see if the new drug works just as well at lowering blood sugar. The…

This study looks at people with type 2 diabetes whose blood sugar is not well controlled with pills. All participants will first receive a short course of intensive insulin therapy in the hospital. Then, they will be randomly assigned to one of three different drug plans to see w…

This study tests whether two types of fish oil, EPA and DHA, can improve metabolic health in people with obesity who are at high risk for type 2 diabetes. Over 12 weeks, 84 participants will take daily capsules of EPA, DHA, or a placebo (corn oil) and undergo specialized tests to…

This pilot study tests whether a remotely delivered mindfulness-based diabetes education program, combined with home blood sugar monitoring, is feasible and acceptable for rural Black adults with type 2 diabetes who have high stress and poorly controlled blood sugar. The study wi…

This study tests whether an interactive video-based education program helps adults with type 2 diabetes improve their blood sugar control and self-care skills. About 60 participants will either receive the video program or standard care. The goal is to see if the videos make it e…

This study looks at whether meals made with local fruits and vegetables can lower blood sugar and fats in people with type 2 diabetes. Eight adults in Uganda will eat five different test meals over five weeks. Researchers will check blood samples to see which food works best.

This study will look at the medical records of 100,000 Chinese adults with type 2 diabetes to compare heart and kidney outcomes between those who took Ozempic and those who took other diabetes medications. The goal is to see if Ozempic leads to fewer heart attacks, strokes, heart…

This study looks at whether low vitamin D levels are linked to higher insulin resistance in people with type 2 diabetes. Researchers will measure insulin resistance using a simple blood test called the triglyceride-glucose index. About 165 adults with type 2 diabetes will partici…

This study compares blood tests from 200 adults with type 2 diabetes and healthy volunteers to see if platelet size and activity are linked to inflammation and blood sugar control. Participants give one blood sample during a routine clinic visit. No treatments or follow-up are in…

This study looks at how the liver makes new sugar from fat and blood molecules in people with and without type 2 diabetes. Researchers will give special tracers and take blood samples to track this process. The goal is to find new ways to lower blood sugar more effectively. About…

This early-stage study tests whether a new drug called DWRX5003 is safe in healthy adults aged 19 to 65. It also measures how the drug moves through the body compared to two other versions. The goal is to gather safety and processing data, not to treat any disease.

This study looks at whether measuring sugar use in a key memory part of the brain can help predict confusion (delirium) after surgery in older adults with type 2 diabetes. Researchers will scan the brains of 154 people before liver surgery and check for confusion afterward. The g…

This study will look at medical records from 10,000 adults in Qatar who have heart disease and diabetes or prediabetes. Researchers will use artificial intelligence to find patterns that predict future heart attacks, strokes, or death. The goal is to create better risk prediction…

This study aims to create an AI-powered 'digital twin' for 50 young people (ages 10-21) with type 2 diabetes. The digital twin will use each person's health data to predict how their diabetes will progress and how they might respond to treatments. Researchers hope this tool will …

This study looks at how fasting during Ramadan affects people with type 2 diabetes. Researchers will compare those who fast and those who don't to see changes in blood sugar control, treatment adherence, and psychological well-being. The goal is to help nurses create better, cult…

This study looks at how thinking abilities (like memory and attention) impact physical functions such as balance, walking, and fear of falling in people with type 2 diabetes. Researchers will test 80 adults aged 40-65 using simple mental and physical tasks. The goal is to better …

This study looks at 20 adults with type 2 diabetes who are starting weight-loss drugs like semaglutide or tirzepatide. The goal is to use advanced PET/CT scans and simple physical tests to detect early muscle and bone changes that could lead to weakness or falls. Findings will he…

This study looks at how a diet low in acid-forming foods (like meat, cheese, and grains) affects kidney function and blood sugar control in people with type 2 diabetes and chronic kidney disease. Researchers will compare a high-acid vs. low-acid diet over 8 weeks in 80 adults, al…

This study aims to create a standard list of what to measure in type 2 diabetes research, called a core outcome set. It will involve 300 participants, including healthcare professionals, researchers, and people with type 2 diabetes. Through online surveys, they will agree on the …

This study looks at how blood sugar levels change in people who may be at risk for diabetes but haven't been diagnosed yet. About 225 adults aged 18 to 70 will wear a continuous glucose monitor for 10-14 days and take special sugar drinks at home and in the hospital. The goal is …

This study looks at whether having type 2 diabetes makes quality of life worse for cancer patients receiving immunotherapy. About 920 adults with solid tumors will fill out surveys at the start, then at 3 and 6 months. The goal is to see if diabetes adds extra challenges during c…

This study will analyze medical records from 400 adults with type 2 diabetes or obesity to see how well semaglutide works over three years for heart, kidney, and metabolic health. Researchers will compare blood sugar control in people taking semaglutide versus other diabetes medi…

This registry will follow 500 people with type 2 diabetes who have already been treated with the Endogenex System. The goal is to collect long-term safety data by tracking any device- or procedure-related side effects. Participants must agree to share their medical records and at…