New study tests exercise and semaglutide combo to fight cognitive decline in diabetes

NCT ID NCT07485062

Not yet recruiting Disease control Sponsor: Western University, Canada Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looks at whether supervised exercise and the diabetes drug semaglutide, alone or together, can improve thinking and brain health in older adults with type 2 diabetes. About 164 people aged 65 and older will take part. They will be assigned to exercise training, a control exercise, semaglutide injections, or standard diabetes care for up to 32 weeks.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: semaglutide (a diabetes drug) and supervised resistance exercise
What this could lead to: If it works, this could point toward a way to protect brain function in older adults with type 2 diabetes using exercise and medication.
What could go wrong: This is a phase 4 trial, but it's still early and small. The results may not apply to everyone, and semaglutide can cause side effects like nausea or stomach issues.

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Conditions

The condition(s) this trial relates to.

Motor Activity type 2 diabetes mellitus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

COGNITIVE DECLINE IN OLDER ADULTS TYPE 2 DIABETES

Contacts and locations

Locations

Western University

London, Ontario, N6A 3K7, Canada

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