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Community-Driven strategies aim to end intergenerational type 2 diabetes in indigenous children

NCT ID NCT07692321

Prevention Sponsor: University of Manitoba Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 09, 2026 · Last updated Aug 04, 2026 · Updated 3 times

Summary

This study works with First Nations communities in Manitoba to design and test ways to prevent type 2 diabetes in children. Pregnant women with or without diabetes are enrolled, and their children are followed from birth. The approach includes breastfeeding support, nutrition and activity guidance, and early screening for blood sugar problems using HbA1c tests and continuous glucose monitors. The goal is to stop the cycle of diabetes passing from one generation to the next.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Breastfeeding and perinatal education and support program; HbA1c screening machines; continuous glucose monitors
What this could lead to
If successful, this could help break the cycle of type 2 diabetes in Indigenous communities by preventing the disease in children from birth.
What could go wrong
This is an observational and co-design study, not a controlled trial, so it may not prove which specific intervention works best. Results depend on community engagement and long-term follow-up.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 600 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Aug 2026

An estimate. Start dates often move.

Expected to finish

Mar 2031

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

The Next Generation Cohort (NextGen) is an established longitudinal birth cohort in Manitoba of First Nations mothers and their offspring exposed to diabetes in utero (PGDM or GDM) and a non-exposed comparator population designed to discover the mechanisms underpinning the increased risk of childhood onset T2D in children exposed to diabetes in utero. We have developed a platform of research based on pre and post-natal measures in collaboration with strong community partnerships. The next natural extension of the NextGen Cohort study is to pilot interventions to decrease the rates of T2D in the offspring. The current project focuses on First Nations mothers and offspring from the four Asinininew Island Lake First Nations: Garden Hill, Red Sucker Lake, St. Theresa Point, and Wasagamach.

Ages

Up to 18 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria for the breastfeeding program: * Pregnant women with type 2 diabetes or no diabetes. * From self-identified Indigenous heritage (e.g., Cree, Oji-Cree, Métis, Anishinaabe, etc.) residing in the four Anisininew communities in the Island Lake region. * Are delivering in Manitoba. * Mother/Father and children must be biological family members. Exclusion Criteria from the breastfeeding program: * Parents or children with type 1 diabetes. * Residing outside of Manitoba. Inclusion criteria for the CGM pro

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Conditions

The condition(s) this trial relates to.

gestational diabetes type 2 diabetes mellitus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Gestational diabetes mellitus (GDM) Type 2 diabetes

How to take part

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  1. The study's own enquiry address

    This study publishes an address for enquiries. See it below .

  2. The places running it

    1 site. The list below names each one and where it is.

  3. The official record

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    Open the record ↗

  4. A doctor treating you

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Contacts and locations

Locations

  • Children's Hospital Research Institute of Manitoba/University of Manitoba

    Winnipeg, Manitoba, R3E 3P4, Canada

    Contact Email: •••••@•••••

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