One pill to tackle three heart risks: could a polypill cut cardiovascular disease?

NCT ID NCT07679828

Not yet recruiting Disease control Sponsor: China Medical University, China Source: ClinicalTrials.gov ↗

First seen Jul 01, 2026 · Last updated Jul 02, 2026 · Updated 1 time

Summary

This trial tests whether a single daily pill that combines treatments for high blood pressure, high cholesterol, and type 2 diabetes can lower the risk of heart disease and dementia. The study involves over 8,000 adults aged 50 to 75 in China who have all three conditions. Participants receive either the combination pill or their usual separate medications, and researchers track their heart health and cognitive function over time.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Fixed-dose combination pill (olmesartan medoxomil/amlodipine, rosuvastatin, and glucose-lowering drugs)
What this could lead to: If successful, this simplified daily pill could make it easier for people with multiple risk factors to prevent heart attacks, strokes, and dementia.
What could go wrong: This is a large trial, but the combination pill may cause side effects or not work better than separate medications. Results may not apply to people outside China.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

cardiovascular disorder diabetes mellitus Dyslipidemias hypertensive disorder inherited lipid metabolism disorder type 2 diabetes mellitus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DIABETES DYSLIPIDEMIA HYPERTENSION

Contacts and locations

Locations

Affiliated Hospital of Chifeng University

Chifeng, Inner Mongolia, China
Central Hospital of Jinzhou

Jinzhou, Liaoning, China
First Hospital of China Medical University

Shenyang, Liaoning, China
Kunshan Hospital of Chinese Medicine

Kunshan, Jiangsu, China
Panjin Central Hospital

Panjin, Liaoning, China
Shandong Provincial Hospital Affiliated to Shandong First Medical University

Jinan, Shandong, China
Shengjing Hospital of China Medical University

Shenyang, Liaoning, China
Suzhou Wujiang District Hospital of Traditional Chinese Medicine

Suzhou, Jiangsu, China
Taixing Second People's Hospital

Taizhou, Jiangsu, China
The Fifth People's Hospital of Wujiang District

Suzhou, Jiangsu, China
The Second Affiliated Hospital of Soochow University

Suzhou, Jiangsu, China
Tiemei General Hospital of Liaoning Health Industry Group

Tieling, Liaoning, China

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