MRI scans reveal Semaglutide's hidden impact on muscle strength

NCT ID NCT07695454

Not yet recruiting Knowledge-focused Sponsor: The Cleveland Clinic Source: ClinicalTrials.gov ↗

First seen Jul 10, 2026 · Last updated Jul 10, 2026

Summary

This study uses advanced MRI and spectroscopy to track how semaglutide therapy changes muscle strength, volume, and quality over six months. Researchers will measure muscle function and fat infiltration in people with type 2 diabetes and obesity. The goal is to understand whether semaglutide affects muscle health beyond just weight loss.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: semaglutide
What this could lead to: If successful, this study could reveal whether semaglutide preserves or harms muscle health during weight loss, guiding better diabetes care.
What could go wrong: This is a small, early observational study with only 10 participants, so results may not apply broadly. It measures muscle changes but does not test a new treatment.

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Conditions

The condition(s) this trial relates to.

obesity disorder type 2 diabetes mellitus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BMI GREATER THAN 30 TYPE 2 DIABETES

Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

Cleveland Clinic

Cleveland, Ohio, 44195, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••

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