Weekly shot could replace daily insulin for diabetes

NCT ID NCT06269107

Completed Disease control Sponsor: Novo Nordisk A/S Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested a new once-weekly injection called IcoSema, which combines two diabetes drugs (insulin icodec and semaglutide), against daily insulin glargine in 485 adults with type 2 diabetes whose blood sugar was not well controlled on oral medications. The goal was to see if the weekly shot could lower blood sugar (HbA1c) as well or better than the daily insulin. The trial lasted about 11 months.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: IcoSema (a combination of insulin icodec and semaglutide)
What this could lead to: If successful, this could offer a once-weekly injection option for type 2 diabetes, potentially improving convenience and blood sugar control compared to daily insulin.
What could go wrong: This is a completed Phase 3 trial, but results are not yet published. The new drug may not prove superior to existing daily insulin, and side effects like nausea or hypoglycemia are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

type 2 diabetes mellitus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

TYPE 2 DIABETES

Contacts and locations

Locations

"Laiko" General Hospital of Athens

Athens, 11527, Greece
"Thermi" Private Hosital

Thessaloniki, 57001, Greece
'G. Gennimatas' General Hospital of Athens

Athens, 115 27, Greece
A.O.U. Policlinico Umberto I

Rome, Lazio, 00161, Italy
AMC Community Endocrinology

Albany, New York, 12203, United States
ASL Avezzano Sulmona L'Aquila - Ospedale San Salvatore - UOC Diabetologia

L’Aquila, Abbruzzo, 67100, Italy
Advanced Clinical Research LLC

Bayamón, 00959, Puerto Rico
Advanced Medical Research

Maumee, Ohio, 43537, United States
Akdeniz University Tip Fakultesi Hastanesi

Antalya, 07058, Turkey (Türkiye)
Akdeniz Üniversitesi Hastanesi- Endokrinoloji

Antalya, 07058, Turkey (Türkiye)
Albuquerque Clin Trials, Inc.

Albuquerque, New Mexico, 87102, United States
Amarillo Med Spec LLP

Amarillo, Texas, 79106, United States
Atlanta Diabetes Associates

Atlanta, Georgia, 30318, United States
Azienda Ospedaliera di Perugia;Ospedale S. Maria della Misericordia

Perugia, 06129, Italy
BSES MG hospital

Mumbai, Maharashtra, 400058, India
BYL Nair Hospital and T N Medical College Department of endo

Mumbai, Maharashtra, 400008, India
Başakşehir Çam ve Sakura Şehir Hastanesi

Istanbul, 34480, Turkey (Türkiye)
Beijing Friendship Hospital, Capital Medical University-Endocrinology

Beijing, Beijing Municipality, 100050, China
CHL Hospitals

Indore, Madhya Pradesh, 452008, India
Care Clinic Sp. z o. o.

Katowice, 40-568, Poland
Casa Sollievo della Sofferenza reparto endocrinologia

San Giovanni Rotondo, FG, 71013, Italy
Casa della Salute di Ceccano - Ambulatori Campus Biomedico

Ceccano (Frosinone), 03023, Italy
Cedar-Crosse Research Center

Chicago, Illinois, 60607, United States
Centrum Terapii Wspolczesnej J.M. Jasnorzewska S.K.A.

Lodz, 90-338, Poland
Chellaram Diabetes Institute

Pune, Maharashtra, 411021, India
Chongqing University Three Gorges Hospital

Chongqing, Chongqing Municipality, 404000, China
Clinhouse Centrum Medyczne

Zabrze, 41-807, Poland
Clinical Research Institute of South Africa

KwaDukuza, KwaZulu-Natal, 4449, South Africa
Clinical Research of Cent FL

Winter Haven, Florida, 33880, United States
Clinical Trials Research_Sacramento

Lincoln, California, 95821, United States
Consano Clinical Research, LLC

Shavano Park, Texas, 78231, United States
Cotton-O'Neil Diab & Endo Ctr

Topeka, Kansas, 66606, United States
Desert Oasis Hlthcr Med Group

Palm Springs, California, 91355, United States
Desert Oasis Hlthcr Med Group

Palm Springs, California, 92262, United States
Diab & Endo Assoc of Stark Co

Canton, Ohio, 44718, United States
Diabetes and Thyroid Ctr of FW

Fort Worth, Texas, 76132, United States
Diabetes, Thyroid and Endocrine Centre

Jaipur, Rajasthan, 302006, India
Dr Pillay's Rooms

Durban, KwaZulu-Natal, 4450, South Africa
Dr R Dulabh

Johannesburg, Gauteng, 1812, South Africa
East Coast Institute For Research

Jacksonville, Florida, 32208, United States
East West Medical Research Institute_Honolulu

Honolulu, Hawaii, 96814, United States
Elite Clinical Trials

Blackfoot, Idaho, 83221, United States
Endeavor Health

Skokie, Illinois, 60077, United States
Endo Res Solutions Inc

Roswell, Georgia, 30076, United States
Endo and Metab Consultants

Rockville, Maryland, 20852, United States
Epic Medical Research

Red Oak, Texas, 75154, United States
Essential Medical Research LLC

Tulsa, Oklahoma, 74137, United States
Evangelismos Hospital

Athens, 10676, Greece
First Valley Med Grp Lancaster

Lancaster, California, 93534, United States
Flourish Research

San Antonio, Texas, 78229, United States
Fmc Science, Llc

Lampasas, Texas, 76550, United States
Fukuwa Clinic_Internal Medicine

Tokyo, 104-0031, Japan
Gabinet Lekarski Malgorzata Saryusz-Wolska

Lodz, 90-132, Poland
General Hospital of Kalamata - B Internal Medicine Department

Kalamata, 24100, Greece
Goa Medical College

Goa, Maharashtra, 403 202, India
Grande Ospedale Metropolitano Niguarda

Milan, 20162, Italy
Grazyna Pulka Specjalistyczny Osrodek "All-Med"

Krakow, 30-033, Poland
Heiwadai Hospital_Internal Medicine

Miyazaki, Miyazaki, 880-0034, Japan
Hengshui People's Hospital (Harrison International Peace Hospital)-Endocrinology

Hengshui, Hebei, 053000, China
Holston Medical Group

Kingsport, Tennessee, 37660, United States
Huizhou Central People's Hospital-Endocrinology

Huizhou, Guangdong, 516001, China
I.N.R.C.A. Istituto Nazionale di Riposo E Cura Per Gli Anziani

Ancona, 60127, Italy
IPGME&R and SSKM Hospital

Kolkata, 700020, India
Jinan Central Hospital

Jinan, Shandong, 250013, China
John Muir Physicians Network

Concord, California, 94520, United States
Juntendo University Hospital_Diabetes, endocrinology and metabolism

Tokyo, 113-8431, Japan
Langeberg Clinical Trials

Cape Town, Western Cape, 7572, South Africa
METTA Clinic (a unit of Healious Global Pvt. Ltd.)

Kolkata, 700039, India
Madras Diabetes Research Foundation

Chennai, Tamil Nadu, 600086, India
Medical Concierge Centrum Medyczne

Warsaw, 02-798, Poland
Methodist Phys. Clinic

Omaha, Nebraska, 68114, United States
Mysore Medical College and Research Institute

Mysore, Karnataka, 570001, India
NBR Polska Tomasz Klodawski

Warsaw, 00-710, Poland
NZOZ Przychodnia Specjalistyczna Medica

Lublin, Lubelski, 20-538, Poland
NZOZ Specjalistyczny Osrodek Internistyczno-Diabetologiczny Małgorzata Arciszewska

Bialystok, Podlaskie Voivodeship, 15-435, Poland
New Venture Medical Research

Wadsworth, Ohio, 44281-9236, United States
Newtown Clinical Research

Johannesburg, Gauteng, 2001, South Africa
North Texas Endocrine Center

Dallas, Texas, 75231, United States
Northeast Research Institute

Fleming Island, Florida, 32003, United States
Oodouri Diabetes, Internal medicine Clinic_Internal Medicine, Diabetes Internal Medicine

Hokkaido, 060-0001, Japan
Oyama East Clinic_Internal Medicine

Tochigi, 323-0022, Japan
PANSTWOWY INSTYTUT MEDYCZNY MSWiA

Warsaw, 02-507, Poland
Peking University People's Hospital-Endocrinology

Beijing, Beijing Municipality, 100044, China
PharmQuest Life Sciences LLC

Greensboro, North Carolina, 27408, United States
Physician's East Endocrinology

Greenville, North Carolina, 27834, United States
Polo Ospedaliero di Chiavari

Chiavari (genova), 16043, Italy
Post Graduate Institute of Medical Education & Research

Chandigarh, 160012, India
Quality Research Inc

San Antonio, Texas, 78209, United States
Ramaiah Memorial Hospital

Bangalore, Karnataka, 560054, India
Roodepoort Medicross Clinical Research Centre

Roodepoort, Gauteng, 1724, South Africa
SMS Medical College & Hospital

Jaipur, Rajasthan, 302004, India
SNZOZ Lege Artis

Bialystok, 15-404, Poland
Sai A Health Wellness LLP

Bangalore, Karnataka, 560080, India
Scripps Whittier Diabetes Inst

La Jolla, California, 92037, United States
Seth GS Medical College & KEM Hospital

Mumbai, Maharashtra, 400012, India
Seyrantepe Hamidiye Etfal Egitim ve Arastirma Hastanesi

Istanbul, 34371, Turkey (Türkiye)
Shanghai Pudong New Area People's Hospital-Endocrinology

Shanghai, Shanghai Municipality, 201200, China
Simcare Medical Research, LLC

Sugar Land, Texas, 77478, United States
Southgate Medical Group, LLP

West Seneca, New York, 14224, United States
T.C. Saglik Bakanligi Pendik Egitim ve Arastirma Hastanesi

Istanbul, 34899, Turkey (Türkiye)
TPMG Clinical Research

Newport News, Virginia, 23606, United States
Tekirdağ Namık Kemal Üniversitesi Hastanesi- Dahiliye

Tekirdağ, 59030, Turkey (Türkiye)
The Affiliated Hospital of Jiangsu University

Zhenjiang, Jiangsu, 212001, China
The Research Group of Lexington LLC

Lexington, Kentucky, 40503, United States
The Second Affiliated Hospital of Nanjing Medical University

Nanjing, Jiangsu, 210011, China
Tokuyama clinic_Diabetic internal medicine

Chiba, 261-0004, Japan
Tokyo-Eki Center-building Clinic_Internal Medicine

Tokyo, 103-0027, Japan
Udyaan Health Care

Lucknow, Uttar Pradesh, 226002, India
Univ Gen Hospital Larisa

Larissa, 41110, Greece
Univ of Alabama_Birmingham

Birmingham, Alabama, 35233, United States
Uniwersyteckie Centrum Kliniczne Regionalne Centrum Diabetologii

Gdansk, 80-214, Poland
Velocity Clinical Res-Dallas

Dallas, Texas, 75230, United States
Velocity Clinical Research- Cedar Park

Austin, Texas, 78759, United States
Velocity Nova Sp. z o.o.

Lublin, 20-362, Poland
Velocity Nova Sp. z o.o.

Staszów, Świętokrzyskie Voivodeship, 28-200, Poland
Wade Family Medicine

Bountiful, Utah, 84010, United States
İstanbul Üniversitesi İstanbul Tıp Fakültesi Hastanesi- Endokrinoloji

Istanbul, 34390, Turkey (Türkiye)
Şişli Hamidiye Etfal Eğitim ve Araştırma Hastanesi- Seyrantepe Yerleşkesi- Endokrinoloji

Istanbul, 34371, Turkey (Türkiye)

More trials for these conditions

Other studies related to the condition(s) this trial covers.