New pill aims to slow Parkinson's in genetically targeted patients

NCT ID NCT06680830

Recruiting now Disease control Sponsor: Neuron23 Inc. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 31, 2026 · Updated 4 times

Summary

This Phase 2 trial tests an oral drug called NEU-411 in 150 adults aged 40-80 with early Parkinson's disease who have a specific genetic marker (LRRK2-driven). The study is double-blind and placebo-controlled, meaning neither patients nor doctors know who gets the real drug. Researchers will measure changes in symptoms using a smartphone app and standard rating scales, and track side effects over about a year.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: NEU-411 (an oral drug that blocks LRRK2 protein activity)
What this could lead to: If successful, this could point toward a treatment that slows or stops early Parkinson's in people with a specific genetic profile.
What could go wrong: This is a Phase 2 trial with only 150 participants, so results may not apply to all Parkinson's patients. The drug may not work better than placebo, and side effects are still being studied.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

Parkinson disease young-onset Parkinson disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

EARLY PARKINSON DISEASE (EARLY PD) IDIOPATHIC PARKINSON DISEASE PARKINSON PARKINSON DISEASE PARKINSON DISEASE, IDIOPATHIC

Contacts and locations

Show contact details

Study contacts

Contact

Email: •••••@•••••

Locations

Augusta University
RECRUITING

Augusta, Georgia, 30912, United States
Azienda Ospedaliero Universitaria Pisana - Stabilimento Ospedaliero Di Santa Chiara
RECRUITING

Pisa, 56126, Italy
Banner Sun Health Research Institute
RECRUITING

Sun City, Arizona, 85351, United States
Baylor College of Medicine
RECRUITING

Houston, Texas, 77030, United States
Beth Israel Deaconess Medical Center
RECRUITING

Boston, Massachusetts, 02215, United States
Central Texas Neurology Consultants
RECRUITING

Round Rock, Texas, 78681, United States
Centrum Medyczne Neuromed
RECRUITING

Bydgoszcz, 85-163, Poland
Cleveland Clinic
RECRUITING

Las Vegas, Nevada, 89106, United States
Clinical Aging Research Unit, Newcastle University
RECRUITING

Newcastle upon Tyne, England, NE4 5PL, United Kingdom
Columbia University
RECRUITING

New York, New York, 10032, United States
Emory University
RECRUITING

Atlanta, Georgia, 30329, United States
Esperanza Clinical
RECRUITING

Murrieta, California, 92562, United States
EvergreenHealth
RECRUITING

Kirkland, Washington, 98034, United States
Fondazione Policilinico Universitario A Gemelli IRCCS
RECRUITING

Rome, 00168, Italy
Hospital Clinic de Barcelona (Hospital Clinic i Provincial) - Barnaclinic S.A.
RECRUITING

Barcelona, 08036, Spain
Hospital Universitari Vall d'Hebron
RECRUITING

Barcelona, 08035, Spain
Hospital Universitario HM Puerta del Sur
RECRUITING

Móstoles, 28938, Spain
Hospital Universitario Virgen del Rocio (HUVR) - Instituto de Biomedicina de Sevilla (IBIS)
RECRUITING

Seville, 41013, Spain
IRCCS Ospedale San Raffaele (HSR) - Dipartimento Di Neurologia
RECRUITING

Milan, 20132, Italy
Icahn School of Medicine at Mount Sinai/Mount Sinai West
RECRUITING

New York, New York, 10019, United States
Inland Northwest Research
RECRUITING

Spokane, Washington, 99202, United States
Instituto de Investigacion Sanitaria Biocruces Bizkaia - Hospital Universitario Cruces
NOT_YET_RECRUITING

Barakaldo, 49003, Spain
Insula Badania Sp. Z o.o.
RECRUITING

Warsaw, 02-699, Poland
Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) - San Raffaele Pisana
RECRUITING

Rome, 00166, Italy
Medical College of Wisconsin
RECRUITING

Milwaukee, Wisconsin, 53226, United States
Medical University of South Carolina
RECRUITING

Charleston, South Carolina, 29425, United States
NZOZ Wielospecjalistyczna Poradnia Lekarska Synapsis Lech Szczechowski
RECRUITING

Katowice, 32-600, Poland
Neuro-Pain Medical Center
RECRUITING

Fresno, California, 93710, United States
Neurology Consultants of Dallas PA
RECRUITING

Dallas, Texas, 75243, United States
Neurology One
RECRUITING

Orlando, Florida, 32825, United States
Ninewells Hospital and Medical School - NHS Tayside
RECRUITING

Dundee, Scotland, DD19SY, United Kingdom
Northwell Health
RECRUITING

Manhasset, New York, 11030, United States

Contact Email: •••••@•••••
Northwestern Medical Group, Department of Neurology
RECRUITING

Chicago, Illinois, 60611, United States
Ochsner Clinic Foundation
RECRUITING

New Orleans, Louisiana, 70121, United States
Oregon Health & Science University (OHSU)
RECRUITING

Portland, Oregon, 97239, United States
Parkinson's Disease and Movement Disorders Center of Boca Raton
RECRUITING

Boca Raton, Florida, 33486, United States
Parkinson's Research Centers of America - Palo Alto
RECRUITING

Palo Alto, California, 94301, United States
Policlinica Gipuzkoa - Centro de Investigacion Parkinson (CIP)
RECRUITING

San Sebastián, Donostia, 20014, Spain
Pro Life Medica Sp. z o. o. ETA Lublin
RECRUITING

Lublin, 20-412, Poland
Quest Research Institute
RECRUITING

Farmington Hills, Michigan, 48334, United States
Rambam Medical Center
NOT_YET_RECRUITING

Haifa, 3109601, Israel
Shaare Zedek Medical Center
RECRUITING

Jerusalem, 9103102, Israel
Sheba Medical Center
RECRUITING

Ramat Gan, 5262000, Israel
St George's Hospital, University of London
RECRUITING

London, England, SW17 0QT, United Kingdom
Struthers Parkinson Center
RECRUITING

Golden Valley, Minnesota, 55427, United States
Sutter Neuroscience Institute
RECRUITING

Sacramento, California, 95816, United States
Tel Aviv Medical Center
RECRUITING

Tel Aviv, 6423906, Israel
The Movement Disorder Clinic of Oklahoma
RECRUITING

Tulsa, Oklahoma, 74136, United States

Contact Email: •••••@•••••
The Ohio State University
RECRUITING

Columbus, Ohio, 43210, United States
The University of Texas Health Science Center at Houston
RECRUITING

Houston, Texas, 77030, United States
Thomas Jefferson University Hospital
RECRUITING

Philadelphia, Pennsylvania, 19107, United States
USF Parkinson's & Movement Disorders Clinic
RECRUITING

Tampa, Florida, 33613, United States
Universidad Autonoma de Madrid (UAM) - Hospital Universitario de La Princesa
RECRUITING

Madrid, 28006, Spain
Universita Degli Studi Della Campania "Luigi Vanvitelli" - Azienda Ospedaliera Universitaria
RECRUITING

Naples, 80138, Italy
Universita Degli Studi Di Padova - Azienda Ospedaliera Di Padova - Clinica Neurologica
RECRUITING

Padua, 35128, Italy
University College London Hospitals NHS Foundation Trust
RECRUITING

London, England, WC1N 3BG, United Kingdom
University of Arkansas
RECRUITING

Little Rock, Arkansas, 72205, United States
University of California, Irvine
RECRUITING

Irvine, California, 92697, United States
University of California, Los Angeles
RECRUITING

Los Angeles, California, 90095, United States
University of Colorado - Anschutz Medical Campus
RECRUITING

Aurora, Colorado, 80045, United States

Contact Email: •••••@•••••
University of Florida
RECRUITING

Gainesville, Florida, 32608, United States
University of Kansas Medical Center
RECRUITING

Kansas City, Kansas, 66160, United States
University of Kentucky
RECRUITING

Lexington, Kentucky, 40536, United States
University of Maryland
RECRUITING

Baltimore, Maryland, 21201, United States
University of New Mexico
RECRUITING

Albuquerque, New Mexico, 87106, United States
University of North Carolina - Chapel Hill
RECRUITING

Chapel Hill, North Carolina, 27599, United States
University of Rochester
RECRUITING

Rochester, New York, 14618, United States
University of Utah Movement Division
RECRUITING

Salt Lake City, Utah, 84108, United States
University of Virginia
RECRUITING

Charlottesville, Virginia, 22903, United States
Vanderbilt University
RECRUITING

Nashville, Tennessee, 37232, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.