Could tweaking a common Parkinson's drug prevent fainting spells?

NCT ID NCT06831500

Recruiting now Symptom relief Sponsor: Julien Bally Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at whether changing the ratio of carbidopa to levodopa in standard Parkinson's medication can reduce orthostatic hypotension—a sudden drop in blood pressure when standing that causes dizziness and fainting. Researchers will give 36 patients with Parkinson's disease or multiple system atrophy (parkinsonian type) single doses of the drug at three different ratios and measure their blood pressure response. The main goal is to see if a larger, more definitive trial is even possible.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Carbidopa/levodopa
What this could lead to: If it works, this could point toward a way to adjust existing Parkinson's medications to reduce dizziness and fainting when standing.
What could go wrong: This is a very early, small feasibility study with only 36 participants. It is designed to see if a larger trial is possible, not to prove the treatment works.

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Conditions

The condition(s) this trial relates to.

multiple system atrophy, parkinsonian type orthostatic hypotension Parkinson disease Shy-Drager Syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MULTI-SYSTEM ATROPHY - PARKINSONIAN TYPE ORTHOSTATIC HYPOTENSION, DYSAUTONOMIC PARKINSON DISEASE

Contacts and locations

Locations

Centre Hospitalier Universitaire Vaudois
RECRUITING

Lausanne, Canton of Vaud, 1012, Switzerland
Centre Hospitalier Universitaire Vaudois (CHUV)
RECRUITING

Lausanne, Canton of Vaud, 1005, Switzerland

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