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Can deep brain stimulation rewire faulty movement circuits? a surgery-time study aims to find out.

NCT ID NCT04957095

Recruiting now Knowledge-focused Sponsor: University of Texas Southwestern Medical Center Source: ClinicalTrials.gov ↗

First seen Jul 22, 2026 · Last updated Jul 23, 2026 · Updated 1 time

Summary

This study investigates how deep brain stimulation (DBS) and medication alter the brain networks that control movement in people with Parkinson's disease or essential tremor. During awake DBS surgery, researchers will record electrical activity from the brain's surface and deep structures while patients perform movement tasks. The goal is to understand the abnormal brain signals behind symptoms like rigidity and slowness, and how DBS and the drug apomorphine may restore normal movement.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
apomorphine injectable solution and subcortical stimulation via deep brain stimulation electrodes
What this could lead to
A better understanding of how brain networks control movement could improve deep brain stimulation therapy for Parkinson's disease and essential tremor.
What could go wrong
This is an observational study during surgery, not a treatment trial. It may not lead to direct clinical changes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

essential tremor Parkinson disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ESSENTIAL TREMOR PARKINSON DISEASE

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • UT Southwestern Medical Center

    RECRUITING

    Dallas, Texas, 75390, United States

    Contact Email: •••••@•••••

    Contact Email: •••••@•••••

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