ESSENTIAL TREMOR

This study is collecting information from 500 people with essential tremor who are using a Boston Scientific deep brain stimulation (DBS) system, which is already approved for use. The goal is to see how the device affects quality of life in real-world settings, not just in contr…

This study tests whether a second focused ultrasound treatment on the opposite side of the brain can further reduce tremors in people with essential tremor who already had one treatment. About 100 participants will be randomly assigned to get the second procedure or continue stan…

This study is testing deep brain stimulation (DBS) surgery for people with Parkinson's disease, essential tremor, or dystonia that doesn't improve enough with medication. DBS uses a device like a pacemaker to send electrical pulses to specific brain areas that control movement. R…

This study tests a new type of brain implant with two leads to better control severe essential tremor in 10 adults who already have a standard implant. The goal is to see if this approach improves tremor control and can lead to a smarter, adaptive system. This is an early feasibi…

This study tests whether using 3-D tractography—a detailed brain imaging method—can make focused ultrasound ablation safer and more effective for people with essential tremor. Twenty-four adults with moderate to severe tremor that hasn't responded to medication will receive the p…

This international study is following 1,000 people who already have or are getting an Abbott deep brain stimulation (DBS) system to treat Parkinson's disease, essential tremor, or dystonia. Researchers will track how well the device controls symptoms and monitor for serious side …

This study tracks 240 adults with essential tremor that doesn't improve with medication. They will receive a non-invasive procedure called MR-guided focused ultrasound, which uses sound waves to target the brain area causing tremors. Researchers will check if tremor control lasts…

This study is testing a computer program called DystoniaNet that uses artificial intelligence to help doctors diagnose isolated dystonia, a movement disorder. The trial will enroll 1000 people with dystonia or other conditions that look like it, such as Parkinson's disease or ess…

This study is testing a new, non-invasive eye scan to see if it can detect Parkinson's disease in its early stages. Researchers will compare the eye scan results with standard brain imaging in 200 participants, including people with early Parkinson's, related movement disorders, …

This study tests a new way to deliver deep brain stimulation (DBS) for essential tremor, called coordinated reset DBS. Instead of constant high-frequency pulses, it uses lower-current patterns that may work better and have fewer downsides. About 23 adults with essential tremor wh…

This early-phase study tests whether low-intensity focused ultrasound (LIFU) can safely reduce tremors in people with essential tremor. Twenty adults will receive six non-invasive ultrasound sessions targeting a small brain area involved in movement. Researchers will measure trem…

This study tests whether transcranial magnetic stimulation (TMS) timed to a person's own tremor cycle can reduce shaking in Essential Tremor and Parkinson's disease. Twenty participants with each condition will receive TMS pulses over the motor cortex while their tremor is record…

This study tests whether low-intensity focused ultrasound (LIFU) can temporarily reduce essential tremor by targeting specific brain areas. Sixty people scheduled for a standard ultrasound procedure will receive up to 25 short ultrasound pulses while researchers measure tremor ch…

This study tests a new way to treat essential tremor, a condition that causes uncontrollable shaking during everyday tasks like writing or holding a cup. Instead of targeting just one brain area, researchers will stimulate two key regions—the supplementary motor area and the cere…

This study tests a new way to use deep brain stimulation (DBS) for essential tremor. Normally, DBS runs all the time, which can cause side effects and make the treatment less effective over time. The researchers will program the device to automatically turn off when you are aslee…

This study tests if a new drug called BP1.4979 can reduce tremors in adults with essential tremor, a condition causing uncontrollable shaking. About 50 participants will take either the drug or a placebo twice daily for 4 weeks. Researchers will check tremor severity and safety t…

This study is testing a wristband that delivers gentle, personalized vibrations to the wrist to help reduce hand tremors in people with essential tremor or Parkinson's disease. About 80 participants will use the device at home over several weeks. The goal is to see if the device …

This study tests a newer type of deep brain stimulation (DBS) that aims to control essential tremor while causing fewer problems with speech, walking, and balance. About 24 adults with hand tremors for at least 3 years will receive both directional and standard DBS to compare whi…

This early study tests whether gentle ultrasound waves aimed at a deep brain area can safely reduce hand tremors. It will include 12 people with Parkinson's, essential tremor, or dystonic tremor who haven't gotten enough relief from medication. The main goal is to check safety, b…

This study follows 60 people with essential tremor or Parkinson's tremor whose symptoms aren't well-controlled by medication. After receiving stereotactic radiosurgery—a precise dose of radiation to a small brain area—participants fill out questionnaires about their quality of li…

This study reviews the medical records of up to 5,000 people who have received deep brain stimulation (DBS) for Parkinson's disease, essential tremor, or dystonia. Researchers want to see how well DBS improves symptoms over time in real-world settings. No new treatments are given…

This study is collecting information from 200 people with Parkinson's disease, dystonia, essential tremor, or other movement disorders who are scheduled to receive radiofrequency (RF) ablation—a procedure that uses heat to target small areas in the brain. The goal is to see how p…

This study looks at how deep brain stimulation (DBS) affects brain activity in people with essential tremor. Researchers will use EEG and MEG to record brain signals with the stimulator on and off, and also test other tremor-relief methods like cooling or medication. The goal is …

This study looks at how deep brain stimulation (DBS) changes attention and the way people with Parkinson's disease, essential tremor, or dystonia perceive emotions in others' faces. Researchers will track eye movements and ask participants to rate facial expressions before, durin…

This study looks at how a treatment called High-Intensity Focused Ultrasound (HiFU) changes brain activity in people with essential tremor (shaking hands). Ten adults over 50 who haven't been helped by standard medications will have their brain waves recorded before and after tre…

This study aims to learn more about how the brain controls speech in people with Parkinson's disease, essential tremor, or dystonia. Researchers will record brain activity during speech tasks while participants undergo deep brain stimulation (DBS) surgery. The study does not test…

This study looks at brain activity in people with Parkinson's disease or essential tremor who are already scheduled for deep brain stimulation (DBS) surgery. Researchers want to understand how the brain handles both movement problems and non-motor issues like memory loss or depre…

This study records brain activity from people with movement disorders like Parkinson's disease, essential tremor, and dystonia. Researchers use scalp electrodes or existing deep brain stimulators to measure electrical signals. The goal is to find patterns linked to symptoms, whic…

This study looks at how two brain areas—the subthalamic nucleus and the ventral intermediate nucleus of the thalamus—help us learn and produce speech. Researchers will temporarily turn deep brain stimulation (DBS) on or off in 80 people with Parkinson's disease or essential tremo…

This study is testing whether a skin biopsy can detect abnormal proteins linked to Parkinson's disease in people with essential tremor, a common movement disorder. Researchers will follow 300 participants aged 50-85 for two years to see who develops Parkinson's. The goal is to fi…

This study is testing whether low-intensity focused ultrasound (LIFUS) can safely change brain activity in people with conditions like Parkinson's disease, essential tremor, epilepsy, or substance abuse. Researchers will use brain recordings and movement tests to see if the ultra…

This study tests whether computer models can help doctors find the best settings for deep brain stimulation (DBS) in people with essential tremor. Researchers will create personalized brain models to predict which stimulation settings work best and cause fewer side effects. The g…

This study looks at how deep brain stimulation (DBS) — a treatment already used for movement disorders — affects voice and speech in people with laryngeal dystonia or voice tremor. Researchers will record brain signals during surgery and measure voice changes afterward. The goal …

This study records brain activity during deep brain stimulation (DBS) surgery in 140 people with Parkinson's disease or essential tremor. Researchers aim to understand brain networks linked to non-motor symptoms like depression, attention problems, and slow thinking. Participants…

This pilot study is testing whether virtual reality motor tasks can help understand functional tremor, a type of movement disorder. Researchers will measure reaction time and brain activity in 48 people with functional tremor, essential tremor, or healthy controls. The goal is to…