ESSENTIAL TREMOR

This study looks at deep brain stimulation (DBS) surgery for people with Parkinson's disease, essential tremor, or dystonia that doesn't improve with other treatments. DBS uses a device like a pacemaker to send electrical signals to parts of the brain that control movement, helpi…

This study tests a new type of brain implant that uses two leads instead of one to control severe essential tremor. Ten adults who already have a standard implant will receive the new system. The goal is to see if it can provide better tremor control and eventually lead to a smar…

This study is a registry that collects information on how well Boston Scientific's approved Deep Brain Stimulation (DBS) system works for people with essential tremor in everyday medical practice. Researchers will track changes in quality of life over time using a special questio…

This study follows 1000 people with movement disorders like Parkinson's disease, essential tremor, and dystonia who receive an Abbott deep brain stimulation (DBS) system. Researchers will measure changes in movement symptoms and track any serious side effects for up to 5 years. T…

This study tests whether a two-stage focused ultrasound treatment on both sides of the brain can better control hand tremors in people with essential tremor, compared to the usual one-side treatment plus medication. About 100 adults will be randomly assigned to either the two-sta…

This study is testing a computer program called DystoniaNet that uses artificial intelligence to help doctors diagnose dystonia, a movement disorder. The goal is to see if the AI can correctly identify dystonia and reduce the time it takes to get a diagnosis. Researchers will stu…

This study tests a new type of brain stimulation for people with essential tremor, a condition that causes shaking during activities like writing or holding objects. The treatment uses magnetic pulses to stimulate two brain areas at once—the supplementary motor area and the cereb…

This study tests a newer type of deep brain stimulation (DBS) that directs electrical pulses more precisely, compared to standard DBS, for people with essential tremor. The goal is to see if the directional approach can better control hand tremors while causing fewer problems wit…

This study tests whether a 3-D brain imaging technique called tractography can make focused ultrasound treatment for essential tremor more precise and safer. About 24 adults with moderate to severe hand shaking that hasn't responded to medication will receive the procedure. Resea…

This study tests a new way to use deep brain stimulation (DBS) for essential tremor. Normally, DBS runs all the time, which can cause side effects and make the treatment less effective over time. The new approach automatically turns off the stimulation when the person is asleep, …

This study tests whether low-intensity focused ultrasound (LIFU) can temporarily reduce tremors in people with essential tremor. Researchers will aim sound waves at specific brain areas in 60 participants who are already scheduled for a related procedure. The goal is to see if LI…

This early study tests whether low-intensity focused ultrasound can safely reduce hand tremors in 12 people with Parkinson's disease, essential tremor, or dystonic tremor who haven't responded well to medication. Participants receive a single session of brain stimulation, and res…

This study follows 240 adults with essential tremor that doesn't improve with medication. They receive a non-invasive procedure called MR-guided focused ultrasound that targets a small area in the brain. Researchers will track tremor severity, side effects, and quality of life fo…

This study tests if a precise radiation treatment called stereotactic radiosurgery can reduce tremors and improve quality of life for people with essential tremor or Parkinson's disease whose medications aren't working well enough. About 60 adults will receive the treatment and t…

This study tests a new way to stimulate the brain called coordinated reset deep brain stimulation (CR-DBS) for people with essential tremor, a condition that causes shaking hands. Researchers want to see if this method is safe and can reduce tremors better than standard stimulati…

This study tests a new drug called BP1.4979 to see if it can reduce tremors in adults with essential tremor, a condition that causes shaking hands. About 50 people will take either the drug or a placebo twice daily for 4 weeks. Researchers will check tremor severity and safety th…

This study is testing a prototype wearable device that uses targeted mechanical stimulation to reduce hand tremors. It aims to see if people with Essential Tremor or Parkinson's Disease can use the device safely and effectively at home over several weeks. The main goal is to gath…

This study looks at how alcohol affects tremors in people with essential tremor, dystonia, and Parkinson's disease. 45 participants will receive either an alcoholic drink or a non-alcoholic placebo on two separate days. Researchers will measure tremor changes using a device and c…

This study is testing whether low-intensity focused ultrasound (LIFUS) can safely change brain activity in people with conditions like Parkinson's disease, essential tremor, epilepsy, or substance abuse disorder. Researchers will measure brain responses and any changes in movemen…

This study looks at how two brain circuits involved in movement and speech work when people learn new sound sequences. Researchers will temporarily turn deep brain stimulation (DBS) on or off in 80 adults with Parkinson's disease or essential tremor while they perform speech task…

This study looks at how deep brain stimulation (DBS) affects brain networks in people with essential tremor. Researchers will use EEG and MEG to record brain activity with the stimulator on and off, and also test other tremor-reducing methods like cooling the limb or medication. …

This study is testing whether a simple skin biopsy can identify people with essential tremor who are at risk of developing Parkinson's disease. Essential tremor affects millions, and some patients later develop Parkinson's. Researchers will follow 300 participants for two years t…

This study tests whether computer models can help doctors find the best settings for deep brain stimulation (DBS) in people with essential tremor. About 25 adults who already have a DBS implant will have their stimulation tested and their tremor measured with sensors. The goal is…

This study looks at how a treatment called High-Intensity Focused Ultrasound (HiFU) affects the brain's communication networks in people with essential tremor. Ten adults over 50 who have not responded to at least two tremor medications will have their brain activity recorded bef…

This study is gathering information from 200 people with Parkinson's disease, dystonia, essential tremor, or other movement disorders who are already scheduled to receive radiofrequency (RF) ablation as part of their routine care. The goal is to see how this treatment affects qua…

This study looks at how deep brain stimulation (DBS) changes the way people with Parkinson's disease, essential tremor, or dystonia pay attention and perceive emotions in others' faces. Researchers will track eye movements and ask participants to rate facial expressions before, d…

This study observes brain activity related to speech in 80 people with Parkinson's disease, essential tremor, or dystonia who are already scheduled for deep brain stimulation (DBS) surgery. Researchers will record electrical signals from brain regions involved in speech while par…

This study will review the medical records of up to 5,000 people who have or are eligible for deep brain stimulation (DBS) to treat Parkinson's disease, essential tremor, or dystonia. Researchers want to see how well DBS improves symptoms over time in everyday medical practice. N…